• Edenberg, Howard (PI)
  • Begleiter, Henri (PI)
  • Li, T. (PI)
  • Reich, Theodore (PI)
  • Hesselbrock, Victor (PI)
  • Schuckit, M. (PI)
  • Porjesz, Bernice (PI)

Project: Research project

Project Details


The major goal of this collaborative study is to elucidate the genetic
mechanisms which are related to the predisposition for alcohol abuse and
dependence. A multicenter multidimensional approach is essential due to
the clinical and potential genetic heterogeneity in alcohol abuse and
dependence, and because phenotypic family assessment requires a
comprehensive approach that utilizes a variety of expertise and
experience. This proposal for a "participating center" involves six separate sites
specifically recruited because of the strengths of each research group.
The following institutions have agreed to participate in this
collaborative study: State University of New York Health Science Center
at Brooklyn, NY, Indiana University School of Medicine, Indianapolis, IN,
University of Connecticut Health Center, Farmington, CT, University of
California, San Diego, CA in conjunction with the Scripps Clinic &
Research Foundation. La Jolla, CA and Washington University School of
Medicine, St. Louis, MO. In addition to the five aforementioned sites the
Intramural Research Program at the National, Institute of Alcohol Abuse
and Alcoholism represents the sixth site. We plan to select a subset of 300 large families (approximately 15
members per family) from an initial set of 600 families with an alcoholic
proband. A uniform ascertainment and assessment protocol will be used for
all family members at each site, using procedures which will yield
standardized clinical and biological data across all sites. In addition
to families with an alcoholic proband we will also conduct identical
studies in "control families" without the presence of alcohol abuse or
alcoholism. The studies of "control families" will be used to establish a
normative data set for electrophysiological and blood markers.
Age-regressed norms will be obtained with this data set. We also propose
to conduct yearly retest of individuals who have not entered the age of
risk (electrophysiological and blood markers, clinical assessment
including alcohol and drug history) in order to assess the stability and
predictability of our potential biological markers. We will conduct segregation analysis as well as a genetic linkage study
using candidate genes and Restriction Fragment Length Polymorphisms.
Effective start/end date9/29/898/31/04


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)


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