DIAGNOSTIC CENTER FOR LINKAGE STUDIES IN BIPOLAR ILLNESS

Project: Research project

Description

Bipolar affective disorder (BP) is heavily influenced by genetic
factors. Linkage studies using molecular genetic methods have been
successful in localizing genes for many disorders in recent years,
including one form of manic depressive illness on chromosome 11. Another
recent report using traditional linkage methods traced manic depressive
illness to the X chromosome in a separate group of families. This and
additional data suggest heterogeneity in this condition, although
neither finding has been independently replicated at this time. A
cooperative study is proposed to ascertain additional families
informative for linkage. The state of Indiana will be an excellent resource for identification
and assessment of large pedigrees with these illnesses. Families,
especially in the rural areas of the state, tend to be stable. There is
an organized state mental health system with a tradition of referral to
the Medical Center in Indianapolis. Probands with bipolar illness will be systematically ascertained at the
9 facilities affiliated with Indiana University Medical Center.
Promising families will have direct interviews of first-degree relatives
and more distant relatives if additional cases of illness are confirmed.
We will be seeking families with a minimum of four or more affectively
ill persons including 2 BP siblings. We have identified 20 such Families
thus far and expect to have 70-80 at the end of the grant period.
Families satisfying criteria will have blood taken for DNA extraction
and for transformation into lymphoblast lines for storage and culture. Probands and ill relatives will be systematically evaluated for biologic
studies. Those suitable will be tested by assessing melatonin response
to light. In addition blood samples will be stored for future marker
determination.
StatusFinished
Effective start/end date9/30/898/31/98

Funding

  • National Institutes of Health: $201,870.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $218,400.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $205,633.00
  • National Institutes of Health
  • National Institutes of Health: $236,222.00

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Mood Disorders
Interviews
Bipolar Disorder
Chromosomes, Human, Pair 11
Organized Financing
X Chromosome
Melatonin
Pedigree
Lymphocyte Activation
Molecular Biology
National Institute of Mental Health (U.S.)
Mental Health
Referral and Consultation
Light
DNA
Genes
Genetic Linkage
Information Centers
Research
Major Affective Disorder 2

ASJC

  • Medicine(all)