MECHANISM OF SPINDLE ASSEMBLY AND CHROMOSOME SEGREGATION

Project: Research project

Description

DESCRIPTION: Aim 1 is to further define how XKCM1 destabilizes microtubules by a series of domain studies. A second series of studies will be focused on establishing evolutionary conservation of the microtubule destabilizing activity of other KinI family members. Aim 2 is to identify and characterize proteins that interact with XKCM1. Here the applicant is particularly interested in identifying potential kinetochore components involved in association of XKCM1 with chromosomes. Aim 3 is to investigate the mechanism of chromosome segregation in Xenopus extracts. Aim 4 is to use reagents, developed in previous studies, to disrupt XKCMP1 function in vivo. Aim 5 is to assess chromosome movement in cells where XKCMP1 function has been manipulated as in the previous aim.
StatusFinished
Effective start/end date8/1/998/31/18

Funding

  • National Institutes of Health: $198,170.00
  • National Institutes of Health: $267,566.00
  • National Institutes of Health: $354,200.00
  • National Institutes of Health: $8,450.00
  • National Institutes of Health: $72,062.00
  • National Institutes of Health: $210,057.00
  • National Institutes of Health: $34,375.00
  • National Institutes of Health: $347,151.00
  • National Institutes of Health: $262,131.00
  • National Institutes of Health: $77,527.00
  • National Institutes of Health: $392,483.00
  • National Institutes of Health: $204,025.00
  • National Institutes of Health: $222,515.00
  • National Institutes of Health: $347,151.00
  • National Institutes of Health: $416,480.00
  • National Institutes of Health: $192,484.00
  • National Institutes of Health: $267,405.00
  • National Institutes of Health: $368,480.00
  • National Institutes of Health: $275,719.00

Fingerprint

Microtubules
Chromosome Segregation
Chromosomes
Kinetochores
Xenopus
Cell Movement
Proteins
Spindle Apparatus
Mitosis
Microtubule-Associated Proteins

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)