Project: Research project

Project Details


Fine needle aspiration biopsy (FNAB) has been shown to be an accurate
method for evaluation of palpable breast masses; however, it has been used
infrequently for evaluation of nonpalpable lesions because accurate needle
placement is difficult. The recent development of a stereotactic
mammography system allows precise localization of mammographically
suspicious lesions with the biopsy needle and localizing wire. This study will evaluate 100 women with nonpalpable mammographic
abnormalities who are referred for needle localization prior to open
surgical biopsy. Utilizing a stereotactic guidance system, FNAB specimens
will be obtained prior to the placement of the localizing hookwire.
Preoperative hookwire localization will direct surgical excision of the
lesion, which will be additionally localized within the surgical specimen
by means of specimen radiography and needle placement. This second
localization will ensure histologic evaluation of the radiographically
abnormal area. FNAB cytology and surgical tissue histology will be
compared and statistically analyzed. This study will allow determination of 1) the efficacy of the stereotactic
system from needle localization and FNAB, and 2) a comparison of FNAB
cytology and surgical specimen histology in the evaluation of nonpalpable
mammographically demonstrable lesions. The recording of health care costs
in the study will allow estimation of the monetary savings afforded by the
possible elimination of the surgical biopsy and will also permit projection
of the potential savings to the national health care system.
Effective start/end date4/1/893/31/93


  • National Institutes of Health: $66,621.00
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)

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