MOLECULAR MECHANISMS OF HEMATOPOIESIS AND LEUKEMIA

Project: Research project

Description

DESCRIPTION Understanding the dynamic interaction between kinases and phosphates is a critical biochemical mechanism in the control of cytoplasmic signaling that mediates blood cell development. Much of the information passed from cell surface receptor-ligand interaction to the nucleus is transmitted via phosphorylated proteins. We wish to understand the molecular basis and signal transduction pathways responsible for the commitment and differentiation of hematopoietic stem/progenitor cells. We intend to address this question by investigating the role of Shp-2, a protein tyrosine phosphatase, in hematopoiesis. We will determine the role of Shp-2 in mediating the development of a common precursor for hematopoietic and endothelial cells. We will also determine the significance of the ras-Erk kinase pathway in mediating Shp-2 control of hematopoiesis Our ultimate goal is that the findings from these studies will allow for the development of improved and less toxic therapies for human leukemias.
StatusActive
Effective start/end date5/1/00 → …

Funding

  • National Institutes of Health: $54,352.00
  • National Institutes of Health: $47,348.00
  • National Institutes of Health: $42,628.00

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Hematopoiesis
Hematopoietic Stem Cells
Leukemia
Phosphotransferases
Protein Tyrosine Phosphatases
Poisons
Cell Surface Receptors
Signal Transduction
Blood Cells
Endothelial Cells
Phosphates
Ligands
Proteins
Therapeutics

ASJC

  • Medicine(all)