The Bipolar Genome Study

Project: Research project

Project Details


DESCRIPTION (provided by applicant): Bipolar disorder (BD) is a serious psychiatric disorder affecting 1-3% of the population. Though family and twin studies support strong heritability, progress towards identifying specific genes has been slow. Our consortium has studied the genetics of bipolar disorder for over 20 years, and collected one of the largest samples of bipolar families and cases in the world. Though genomewide association studies (GWAS) have identified some genes and a significant polygenic component, these mapping approaches have had only limited success. It has been proposed that this missing heritability is transmitted in part through a large number of rare variants of strong genetic effect. Such rare variants might range in frequency from uncommon (
Effective start/end date7/1/124/30/16


  • National Institutes of Health: $667,424.00
  • National Institutes of Health: $676,465.00
  • National Institutes of Health: $827,481.00


  • Medicine(all)


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