MIDWEST SEXUALLY TRANSMITTED DISEASES RESEARCH CENTER

Project: Research project

Description

This application for a Sexually Transmitted Diseases (STD) Research Center
is a consortium agreement between Indiana University, Northwestern
University, and the University of Wisconsin at Madison. It is a
multidisciplinary project with a primary focus on those pathogens which are
most prevalent in the United States and which produce the most morbidity in
women. A central theme is development of a better understanding of
structure and function of microbial surface components, factors which
regulate them, and interactions with the immune system. Eight projects are
proposed. One has as its objective determination of structural variations
in herpes simplex glycoproteins which relate to functional differences. A
second is focused on pilus antigenic variation in Neisseria gonorrhoeae,
its classification, and correlation with antibody reactivity in infected
people. Another project focuses on further characterization of the
neisserial common antigen OMP-MC in terms of its surface exposure and
degree of conservation of peptide structure in order to identify
potentially protective epitopes. Two projects will study the immune
response to Chlamydia trachomatis infections; one will focus on epitope-
specific antibody response to the major outer membrane protein of the
organism and the other on the T cell response to the putative
hypersensitivity antigen. Two projects are directed at increasing our
understanding of regulation of the replication of papillomaviruses. One of
these will examine the effect of pregnancy on virus replication while the
other will concentrate on defining the molecular factors which regulate
gene expression. Another project will prospectively evaluate the efficacy
of three behavioral intervention models in reducing the incidence of
recurrent chlamydial infection. These projects will be supported by four
cores; an administrative one, a clinical one which will gather data and
specimens for all of the above projects, a biostatistics one which will
assist in further study design and data evaluation, and a
chlamydia/laboratory core which will process specimens for each of the
projects and provide chlamydia cultures, serologies, and immunotyping.
Extensive collaboration between the projects exists and will be reinforced
at regional scientific/administrative meetings which will be held every
four months. In addition, research developmental funds are requested and
examples of the types of projects for which these might be used are
provided. An evolving relationship between the Indiana University School
of Medicine and the University of Moi in Eldoret, Kenya is also described.
StatusFinished
Effective start/end date7/1/917/31/10

Funding

  • National Institutes of Health: $1,447,929.00
  • National Institutes of Health: $1,450,816.00
  • National Institutes of Health: $9,830.00
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  • National Institutes of Health: $1,486,128.00
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health: $1,355,808.00
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,413,852.00
  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $666,728.00
  • National Institutes of Health
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  • National Institutes of Health: $30,219.00
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  • National Institutes of Health: $1,381,240.00
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  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health: $1,515,945.00
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health: $1,466,231.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,277,362.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $65,058.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health
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Fingerprint

Sexually Transmitted Diseases
Haemophilus ducreyi
Infection
Haemophilus Infections
Chancroid
Local Anti-Infective Agents
Research
Biostatistics
Epitopes
Neisseria gonorrhoeae
Antigens
Human Herpesvirus 2
Antigenic Variation
Chlamydia
Chlamydia trachomatis
Chlamydia Infections
Herpes Simplex
Gonorrhea
T-Lymphocytes
Kenya

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)