Endogenous Mitochondria Resistance to Acute Kidney Injury

Project: Research project

Description

DESCRIPTION (provided by applicant): Acute kidney injury (AKI) occurs in 5-7% of all hospital admissions and recent evidence has shown that even minor changes in renal function are associated with increased risk of death. In the ICU, AKI is associated with 50% mortality, a statistic which has not changed even with dialysis therapy. In fact the Acute Renal Failure Trial Network study, a combined VA and NIH sponsored dialysis dosing study, showed no change in mortality statistics when comparing dialysis dosing. Clearly new approaches are urgently needed to address this life-threatening disease. Given the fact that the VA population is aging, prone to diabetes and hypertension, AKI is a major health problem in this group. Upon completion of this VA Merit Review, investigators in the renal community will have new targets for small molecular drug discovery that should ameliorate the mortality associated with AKI.
StatusFinished
Effective start/end date10/1/149/30/18

Funding

  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Acute Kidney Injury
Mitochondria
Dialysis
Mortality
Kidney
Drug Discovery
Research Personnel
Hypertension
Health
Population
Therapeutics

ASJC

  • Medicine(all)