Project: Research project

Project Details


The Gordon Conference on Second Messengers and Protein Phosphorylation in
June 1992 will concentrate on the role of protein phosphorylation in the
control of cellular function. The whole area of protein kinases and
phosphatases is moving very rapidly, at the levels of both cell biology and
molecular structure. The first crystal structure of a protein kinase
catalytic subunit has just been published, and will likely presage a new
era in structure-function analysis in the kinase family. The widespread
importance of SH2 domains as docking motifs for Tyr(P) is emerging. New
advances in the area of growth-factor activated protein kinases (MAP2
kinases, ERK'S) are breaking down the distinction between protein Ser/Thr
and protein Tyr kinases. Tyr phosphatases are now an established and
fast-growing family and the identification of a Vaccinia phosphatase
capable of acting on Tyr(P) and Ser(P) challenges the original Ser/Thr
versus Tyr classification. These, and other, components feed into the
control of cell growth and division, metabolism, gene expression, indeed
virtually all areas of cellular function. The Conference provides a unique and lively forum for the exchange of
information, ideas and prospects for future work. Over the last two years,
approximately 80% of the participants in the conference presented data
either in posters or as speakers. Such active participation by the
conferees at all levels, including graduate students, postdoctoral fellows
as well as junior and senior investigators, encourages discussion and
fosters new interactions. The sessions planned for the 1992 Conference are: 1) Protein kinase
structure and substrate recognition; 2) Protein phosphorylation and the
cell cycle; 3) Ser/Thr protein phosphatases in cellular regulation; 4)
Tyrosine kinases and SH2 domains; 5) Protein kinases in growth and
differentiation 6) Tyr Protein phosphatase family; 7) Cyclic nucleotides
and G-proteins 8) Signal transduction and gene expression.
Effective start/end date6/1/925/31/93


  • National Institutes of Health


  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.