NEONATAL AND FETAL LEUCINE METABOLISM

Project: Research project

Project Details

Description

Leucine, a key essential branched chain amino acid, may have a
role in the regulation of protein metabolism. In addition,
measurements of leucine kinetics have been used as a model to
estimate whole body rates of protein turnover, synthesis,
breakdown and oxidation. Currently, there is little information
concerning leucine kinetics in the neonatal period, and limited
knowledge of fetal leucine metabolism. These studies will determine leucine kinetics in specific human
neonatal populations (term normal newborns, small and large for
gestational age infants, and premature neonates) in a variety of
nutritional states (fasting versus feeding, enteral versus
parenteral) using a constant tracer infusion of 1-13C leucine
combined with respiratory calorimetry. In addition, similar
techniques (using 1-14C leucine) will be employed to quantitate
leucine metabolism in the normal and experimental intrauterine
growth retarded fetal and neonatal lamb. The performance of these studies will 1) generate new
information concerning leucine metabolism in several important
neonatal populations, 2) determine how alterations in the
intrauterine environment might affect fetal and neonatal leucine
(and protein) metabolism, 3) further the understanding of protein
accretion in the neonatal period, and 4) provide an objective
means to assess different nutritional strategies.
StatusFinished
Effective start/end date7/1/886/30/93

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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