Project: Research project

Project Details


The long term objectives are to understand the physiologic changes that
occur during the growth and development of the respiratory system as well
as the changes produced by injury to the lungs early in life. In infancy,
the two primary insults to the lungs occur from lower respiratory tract
infections (LRI) and the medical support required or premature infants
which results in bronchopulmonary dysplasia (BDP). There has been
increasing concern that these early pulmonary insults may have chronic
sequellae and contribute to the development of chronic obstructive airways
disease in adults. Pulmonary function testing in infants has been limited by patient
cooperation and the lack of easily performed, non-invasive procedures.
Non-invasive techniques for obtaining partial expiratory flow-volume curves
and total respiratory system compliance have recently been described for
use in infants. This investigator proposes to employ these techniques in
the following studies: 1) classify BPD in terms of the degree of pulmonary dysfunction. 2) evaluate bronchodilator responsiveness in infants with BPD and with LRI. 3) evaluate prospectively the relationships of LRI's pulmonary function and
bronchial reactivity during the first year of life. 4) evaluate the relationship between the progression of pulmonary
dysfunction and bronchidilator responsiveness as infants progress from
respiratory distress syndrome to BPD.
Effective start/end date3/1/842/28/89


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)

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