Project: Research project

Project Details


The purpose of the proposal is to modify and test research
instruments which can be used to effectively screen samples of
North American Indians and non-Indians age 65 years and over in a
community survey in Manitoba, Canada, for dementia and also to
determine differential diagnosis of the dementing disorders,
particularly Alzheimer's Disease. Data to be collected will allow
for the development of a screening algorithm for dementia and
hopefully also for Alzheimer's Disease. This will be accomplished
by means of a four stage design where Stage I involves the
translation of the screening instrument and the establishment of
cut-off points for Indians and non-Indians by administering the
instruments to groups of known demented and non-demented subjects.
Stage II involves the community survey by specially trained field
workers. Stage III involves a comprehensive psychiatric and
neurological evaluation of both cases and a sampling of non-cases
identified from the community survey for clinical diagnosis and
Stage IV involves the development of the screening algorithm from
these data. The study will be conducted in Winnipeg with a sample of non-
Indians (n=200) and in two Indian locations for a total of 205
Indians. This proposal is a resubmission of a previous application to
undertake a comparative study of the prevalence of dementing
disorders in these populations. The proposal has been
substantially altered to address methodological issues which arose
from the grant review. The solution of these methodological
problems would be pertinent not only for the eventual completion
of the original prevalence study but also for similar
epidemiological studies involving geographically isolated,
culturally distinct populations elsewhere in the world.
Effective start/end date3/1/892/28/93


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)

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