NATIONAL GENE VECTOR LABORATORY

Project: Research project

Project Details

Description

IU presents an excellent environment for the development of a NGVL. The institution has built a strong gene therapy program with over eleven NIH-funded researchers pursuing clinical gene therapy. The close collaborative efforts of the gene therapy investigators has led to the successful competition for two program projects and the designation as a Centers of Excellence in Molecular Hematology. A Vector Production Facility is currently funded as a core for two existing program grants. The applicants are proposing to expand the current facility to provide viral vectors to outside investigators as a member of the NGVL. The NGVL at IU will: 1) provide a mechanism for review, generation and distribution of clinical grade vector to investigators in the gene therapy field; 2) generate vector producer cell lines and supernate intended for clinical use; 3) certify vectors for clinical use based on Food and Drug Administration (FDA) guidelines under good manufacturing practice (GMP) and good laboratory practice (GLP) specifications; and 4) provide regulatory support for investigators using vectors generated in the NGVL.
StatusFinished
Effective start/end date8/1/958/31/09

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,049,938.00
  • National Institutes of Health: $1,694,989.00
  • National Institutes of Health
  • National Institutes of Health: $1,251,902.00
  • National Institutes of Health: $890,661.00
  • National Institutes of Health
  • National Institutes of Health: $56,046.00
  • National Institutes of Health: $1,265,524.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $442,875.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,842,795.00
  • National Institutes of Health: $1,941,324.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,609,334.00
  • National Institutes of Health: $1,259,004.00
  • National Institutes of Health: $2,622,303.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $18,000.00
  • National Institutes of Health

ASJC

  • Medicine(all)

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