NATIONAL GENE VECTOR LABORATORY

Project: Research project

Description

IU presents an excellent environment for the development of a NGVL. The institution has built a strong gene therapy program with over eleven NIH-funded researchers pursuing clinical gene therapy. The close collaborative efforts of the gene therapy investigators has led to the successful competition for two program projects and the designation as a Centers of Excellence in Molecular Hematology. A Vector Production Facility is currently funded as a core for two existing program grants. The applicants are proposing to expand the current facility to provide viral vectors to outside investigators as a member of the NGVL. The NGVL at IU will: 1) provide a mechanism for review, generation and distribution of clinical grade vector to investigators in the gene therapy field; 2) generate vector producer cell lines and supernate intended for clinical use; 3) certify vectors for clinical use based on Food and Drug Administration (FDA) guidelines under good manufacturing practice (GMP) and good laboratory practice (GLP) specifications; and 4) provide regulatory support for investigators using vectors generated in the NGVL.
StatusFinished
Effective start/end date8/1/958/31/09

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,049,938.00
  • National Institutes of Health: $1,694,989.00
  • National Institutes of Health
  • National Institutes of Health: $1,251,902.00
  • National Institutes of Health: $890,661.00
  • National Institutes of Health
  • National Institutes of Health: $56,046.00
  • National Institutes of Health: $1,265,524.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $442,875.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,842,795.00
  • National Institutes of Health: $1,941,324.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,609,334.00
  • National Institutes of Health: $1,259,004.00
  • National Institutes of Health: $2,622,303.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $18,000.00
  • National Institutes of Health

Fingerprint

Research Personnel
Genetic Therapy
Organized Financing
Genes
Hospital Distribution Systems
Hematology
United States Food and Drug Administration
Guidelines
Cell Line
Safety
Investigational New Drug Application
Certification
Toxicology

ASJC

  • Medicine(all)