• Geraci, Mark, (PI)
  • Wagner, Wiltz (PI)
  • Voeikel, Norbert F. (PI)
  • Reeves, John T. (PI)
  • Nicolls, Mark Robert (PI)
  • Tuder, Rubin M. (PI)
  • Grover, Robert (PI)
  • O'Brien, Richard F. (PI)
  • Bull, Todd (PI)
  • Voelkel, Nobert F. (PI)
  • McMurty, Ivan (PI)
  • Fagan, Karen (PI)
  • Rodman, David (PI)
  • Irwin, David Charles (PI)
  • Dempsey, Edward Charles (PI)
  • Klemm, Dwight (PI)
  • Weiser-Evans, Mary (PI)
  • Cabirac, Gary (PI)
  • McMurty, Ivan F. (PI)
  • Moore, Lorna G. (PI)
  • O'Brien, Richard (PI)
  • Stelzner, Thomas (PI)
  • Weil, John V. (PI)
  • McMurtry, Ivan (PI)
  • Stenmark, Kurt R. (PI)

Project: Research project


This is a resubmission seeking renewal of a 20-year program
encompassing 5 sub-projects which investigate mechanisms and
implications of various responses to hypoxia. Three of these continue
a long standing line of investigation concerning the pulmonary
circulation-the development of vasoconstriction and pulmonary
hypertension in response to hypoxia. The proposed studies explore
direct effects of hypoxia on pulmonary vascular endothelium and smooth
muscle, genetic determinants, and the role of the adventitial
fibroblasts in the development of hypoxic pulmonary hypertension.
Other projects propose to investigate the ventilatory response to
hypoxia and its modulation by genetic factors and the effect of hypoxia
on systemic vascular response to pregnancy. There is considerable
cross-talk amongst these projects with respect to common underlying
scientific principles, shared expertise and resources. Information
resulting from these studies should provide insights into the effects
of hypoxia on the pulmonary circulation, ventilatory control, and
systemic circulatory changes in pregnancy.
Effective start/end date4/1/776/30/20


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


Pulmonary Hypertension
Blood Vessels
Modifier Genes
Endothelial Cells
prostacyclin synthetase
Phosphodiesterase 5 Inhibitors
Inborn Genetic Diseases
Loss of Heterozygosity
Gene Expression Regulation
Genetic Polymorphisms
Cytoplasmic and Nuclear Receptors
Fluorescence In Situ Hybridization
Genetic Promoter Regions
Pulmonary Artery


  • Medicine(all)