Project: Research project

Project Details


DESCRIPTION This revised
application is a proposal aimed at determining the potential of
preoperative neurobehavioral data as predictors of outcome of anterior
temporal lobectomy (ATL), and expanding the traditional end point of
seizure outcome to include neurobehavioral consequences (neuropsychological
and psychosocial). Predictors will consist of preoperative
neuropsychological measures (cognition, memory, language, musical
perception, attention; results of intracarotid amytal memory procedures),
psychosocial measures (psychopathology, affect, activities of daily living
and vocational status), EEG (extra- and intracranial, ictal and interictal)
MRI and PET (in a subsample). In a prospective longitudinal design, 30 new
patients per year (total n=120) will be evaluated preoperatively and
reevaluated 2 weeks, 12 months and then 24 months after surgery. Recently
operated patients (n=60) with baseline data will be similarly studied, with
a potential follow-up of up to 10 years. They will be compared to
non-operated patients with partial epilepsy (n=30) and normal controls
(n=30) studied at the same intervals. Systematic examination of
interactions between the predictor variables and reorganization underlying
outcome. For example, the investigators will test the hypothesis that
better postoperative memory and seizure control is obtained in patients
with greater specificity of neural lateralization of neurobehavioral and
EEG markers and presence of neuropsychological abnormality. The
investigators will also attempt to establish objective criteria for
neurobehavioral outcome of ATL including the exploration and validity of
several new measures.
Effective start/end date6/1/915/31/96


  • National Institutes of Health: $161,531.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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