Project: Research project

Project Details


DESCRIPTION: (provided by applicant)
For almost three years decades, Regenstrief Institute investigators have
successfully captured electronic medical information for clinical and research
purposes. They have been leaders in the field of electronic medical record
standards. They have built an operational, city-wide medical informatics
network (consisting of Indianapolis? five major hospital systems). Building on
these proven strengths, we propose to create an "Indianapolis Pathology
Informatics Network", supplementing these five major systems with Indiana?s
Cancer Registry, the Veteran?s Health system, and a large pathology group. The
included hospitals account for roughly 95 percent of the city?s
hospitalizations and reported cancer cases. This population-based database
will initially provide access to roughly 1.5 million pathology reports and 4.5
million tissue blocks. These data will be linked to hospital laboratory
results, radiology reports, medication orders, discharge summaries, diagnostic
codes, procedure codes, dates of encounters, and cancer registry data from all
participating hospitals. We will base our described distributed system on
those operating systems, database systems, programming languages , and
software (open-source as available) that will facilitate low-cost and secure
national implementation. We will allow for several different query methods of
the resultant database, building a multi-tier system that will distribute
queries to each of the SPRs, authenticate users, de-identify and encrypt all
clinical information, and audit the entire process. We will collaborate with a
well-established leading company (A-Life) and an expert in the field of NLP in
order to automatically code pathology reports into UMLS. Pathologists from
each of the six participating hospitals have agreed to commit time to
coordinating activities and reviewing automatically coded data streams from
their respective sites. Published experts in the fields of Internet
communication, the Next Generation Internet, de-identification of patient
data, and security issues will further ensure the success of this valuable
Effective start/end date8/13/017/31/08


  • National Institutes of Health: $1,573,567.00


  • Medicine(all)


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