NEUROBIOLOGICAL SUBSTRATES OF ANXIETY &PANIC DISORDER

Project: Research project

Description

Anxiety disorders are the most prevalent psychiatric disorders and appear
to be a heterogenous group of disorders. The neurobiology of anxiety
disorders is still poorly understood. However, several limbic structures
have been consistently implicated in the neurobiological mechanisms
underlying anxiety such as the hypothalamus, amygdala, and others. Several
brainstem structures such as the locus ceruleus and the raphae nuclei have
also been implicated in the etiology of anxiety disorders. The posterior
hypothalamus appears to be a key region in the expression of anxiety with a
neuronal circuit capable of eliciting the
physiological and behavioral components of anxiety, especially resembling a
panic attack. Many CNS regions implicated in anxiety, such as the amygdala
and locus ceruleus appear to interact with the hypothalamus and elucidation
of these interactions will significantly expand our understanding of
anxiety disorders. This study will examine these mechanisms by local
microinjection of drugs and pharmacologically manipulating neurotransmitter
systems in rats and studying the effects of these procedures on heart rate,
respiration, blood pressure, catecholamine levels and locomotion as well as
three laboratory tests of anxiety that appear to regulate anxiety at each
of the above mentioned CNS sites. Specifically, this research proposes to:
1) characterize the effects of modifying GABA neurotransmission in the
posterior hypothalamus of rats on anxiety with particular emphasis on the
possible involvement of this region in the etiology of panic disorders; 2)
study the role of amygdala in anxiety local pharmacological manipulations
of locus ceruleus on anxiety and determine the interaction of posterior
hypothalamus with this region; 3) study the effects of pharmacological
manipulations of locus ceruleus on anxiety and determine the interaction of
the posterior hypothalamus with the locus ceruleus. The results of the
proposed study will increase our understanding of the anxiety disorders and
might help us devise better pharmacological strategies for their treatment.
StatusFinished
Effective start/end date9/1/898/31/94

Funding

  • National Institutes of Health
  • National Institutes of Health: $98,637.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $108,689.00

Fingerprint

Panic Disorder
Anxiety Disorders
Anxiety
Locus Coeruleus
Hypothalamus
Amygdala
Pharmacology
Posterior Hypothalamus
Raphe Nuclei
Neurobiology
Locomotion
Synaptic Transmission
gamma-Aminobutyric Acid
Catecholamines
Psychiatry
Respiration
Heart Rate
Blood Pressure

ASJC

  • Medicine(all)