• Fife, Kenneth (PI)
  • Roman, A.N.N. (PI)
  • Rosenthal, Raoul (PI)
  • Wilde, Charles (PI)
  • Newhall, Wilbert (PI)
  • Hui, Siu (PI)
  • Jones, Robert (PI)

Project: Research project


This application is for renewal of a Sexually Transmitted Diseases Research
Center Program Project. The overall objective is to focus the talents of
investigators from a variety of disciplines on the overall problem of
sexually transmitted diseases (STD's), and in specifically on questions
related to the immunology and pathogenesis of selected sexually
transmissible pathogens. We are requesting funding for the renewal of four
currently funded projects and five core facilities, and for two additional
projects. The currently funded projects are "Host response to gonococcal
peptidoglycan", "Growth cycle dependence of chlamydial surface structure",
"The Biology of Human Papillomavirus Type 6" and "Immune response in
genital chlamydial infections". The projects which we would like to add
are one which has as its objective elucidation of the mechanism by which
Hepatitis B virus suppresses interferon production in infected cells, and
one which has as its objective the development of mathematical models and
computer simulations to study transmission patterns and effectiveness of
interventions in sexually transmitted diseases with the initial emphasis on
Chlamydia trachomatis infections. The Cores which would support the
activities of these projects are Administrative, Clinical, Biostatistical,
Immunology, and Chlamydial Culture. The Research Center has a close
working relationship with the Bell Flower Clinic. It is through this
facility that most of the clinical aspects of the research are conducted,
and also that students, housestaff, and fellows, receive training in the
diagnosis and management of STDs. The individual investigators of the
center function as a closely integrated team with formal bi-weekly research
conferences as well as a variety of informal groupings and interactions
which are dictated by changing research interests.
Effective start/end date8/1/837/31/90


  • National Institutes of Health


Sexually Transmitted Diseases
Allergy and Immunology
Human papillomavirus 6
Cercopithecine Herpesvirus 1
Theoretical Models
Research Personnel


  • Medicine(all)
  • Immunology and Microbiology(all)