SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH

Project: Research project

Description

The basic goal of this application is to utilize a hemisection model of the spinal cord in which a gap is created and a mini-guidance channel filled with Schwann cells is inserted. In addition, the model incorporates two additional elements that are intended to maximize the elongation of regenerating axons into the distal cord. These are the administration of methylprednisilone plus the slow release of various neurotrophins via an osmotic mini-pump just caudal to the bridge. Taken together the specific aims of this model could be described as one with a most comprehensive attempt to maximize regeneration into the host cord tissue caudal to a Schwann cell bridged lesion.
StatusFinished
Effective start/end date5/15/984/30/09

Funding

  • National Institutes of Health: $340,921.00
  • National Institutes of Health
  • National Institutes of Health: $173,234.00
  • National Institutes of Health: $40,000.00
  • National Institutes of Health: $349,125.00
  • National Institutes of Health: $349,125.00
  • National Institutes of Health: $165,850.00
  • National Institutes of Health
  • National Institutes of Health: $332,950.00
  • National Institutes of Health: $169,361.00

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Schwann Cells
Nerve Growth Factors
Spinal Cord
Glial Cell Line-Derived Neurotrophic Factor
Regeneration
Axons
Spinal Cord Injuries
Brain-Derived Neurotrophic Factor
Central Pattern Generators
Brain Stem
Glial Cell Line-Derived Neurotrophic Factor Receptors
Extremities
Central Nervous System
Transplants
Efferent Pathways

ASJC

  • Medicine(all)
  • Neuroscience(all)