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Lafora Epilepsy - Basic mechanisms to therapy

Roach, P.

National Institutes of Health

7/1/166/30/21

Project: Research projectResearch Program Projects

Lafora Disease
Glycogen
Glycogen Synthase
Therapeutics
Pharmaceutical Chemistry

Treating bone deterioration associated with chronic kidney disease

Allen, M.

National Institutes of Health

7/1/166/30/20

Project: Research projectNon-HHS Research Projects

Chronic Renal Insufficiency
Diphosphonates
Bone and Bones
Veterans
Kidney
Perfusion Imaging
Perfusion
Clinical Trials
Neoplasms
Patient Care

HSC-Independent Mechanisms Underlying JMML

Chan, R. & Yoder, M.

National Institutes of Health

7/1/166/30/18

Project: Research projectExploratory/Developmental Grants

Hematopoietic Stem Cells
Leukemia
Transplants
Recurrence
Tissue Donors
Autophagy
Lipid Metabolism
Non-alcoholic Fatty Liver Disease
Alcohols
Liver
Hematopoiesis
Hematopoietic Stem Cells
Chromatin
Heterochromatin
Cell Transplantation

Novel mediators of FGF23 bioactivity

White, K.

National Institutes of Health

7/1/166/30/18

Project: Research projectExploratory/Developmental Grants

Phosphates
Metabolic Bone Diseases
Hypophosphatemic Rickets
fibroblast growth factor 23
Chronic Kidney Disease-Mineral and Bone Disorder

Protective pathways in sepsis-induced renal injury

Dagher, P.

National Institutes of Health

7/1/166/30/20

Project: Research projectNon-HHS Research Projects

Endotoxins
Sepsis
Macrophages
Kidney
Wounds and Injuries

7/7 Psychiatric Genomics Consortium: Finding actionable variation

Edenberg, H.

National Institutes of Health

6/20/163/31/21

Project: Research projectResearch Project--Cooperative Agreements

Genomics
Psychiatry
National Institute of Mental Health (U.S.)
Therapeutic Human Experimentation
Genome-Wide Association Study

Nupr1 is a novel target in bone metabolism

Robling, A.

National Institutes of Health

6/15/165/31/18

Project: Research projectExploratory/Developmental Grants

Nuclear Proteins
Bone and Bones
Sample Size
Femur
Osteogenesis Imperfecta

Elucidating new and old roles for autophagy-like proteins in Toxoplasma gondii

Sullivan, W.

National Institutes of Health

6/15/165/31/18

Project: Research projectExploratory/Developmental Grants

Autophagy
Toxoplasma
Parasites
Proteins
Post Translational Protein Processing

Long noncoding RNAs in alcoholic liver disease

Liangpunsakul, S.

National Institutes of Health

6/10/165/31/18

Project: Research projectExploratory/Developmental Grants

Long Noncoding RNA
Alcoholic Liver Diseases
Untranslated RNA
Western World
Transcriptome
Leucine
Phosphotransferases
Parkinson Disease
GTP Phosphohydrolases
Mutation

Translational Epigenetic Markers for Early Diagnosis of FASD

Zhou, F.

National Institutes of Health

6/1/165/31/18

Project: Research projectExploratory/Developmental Grants

Fetal Alcohol Spectrum Disorders
Epigenomics
Placenta
Early Diagnosis
Alcohols
Mass spectrometry
Proteins
RNA
Explosions
Data structures
RNA Precursors
Protein Splicing
Messenger RNA
Paclitaxel
Computational Biology
Ryanodine Receptor Calcium Release Channel
Breast Neoplasms
Drug Therapy
Post-Traumatic Stress Disorders
Endoplasmic Reticulum
Weight Loss
Obesity
Interpersonal Relations
Eating
Health
Exome
Parkinson Disease
Genes
Pedigree
Neurodegenerative Diseases
Oral Health
Social Support
Dental Care
Community Networks
Hispanic Americans

A unified method to study heterogeneity in treatment effect

Shen, C.

National Institutes of Health

4/1/161/31/19

Project: Research projectResearch Project

Software
Implantable Defibrillators
Therapeutics
Patient Outcome Assessment
Pharmaceutical Preparations

Small-Molecule Antagonists of Ral GTPases in Cancer

Meroueh, S.

National Institutes of Health

4/1/163/31/21

Project: Research projectResearch Project

GTP Phosphohydrolases
Non-Small Cell Lung Carcinoma
Neoplasms
Pharmacokinetics
Heterografts

The role of primary cilia in glaucoma pathogenesis

Sun, Y.

National Institutes of Health

3/1/162/28/21

Project: Research projectResearch Project

Cilia
Intraocular Pressure
Oculocerebrorenal Syndrome
Glaucoma
Trabecular Meshwork
Betamethasone
Premature Birth
Pharmacokinetics
Adrenal Cortex Hormones
Therapeutics
Opportunistic Infections
Toxoplasma
Acquired Immunodeficiency Syndrome
HIV
Guanabenz

Prophylaxis against malaria to enhance child development

John, C. & Bangirana, P.

National Institutes of Health

1/1/1612/31/20

Project: Research projectResearch Project

Child Development
Malaria
dihydroartemisinin
Pregnant Women
Mothers
Computational Biology
Drug Interactions
Polypharmacy
Pharmacokinetics
Pharmacology

ChLorthalidone In Chronic Kidney Disease (CLICK) Study

Agarwal, R.

National Institutes of Health

12/15/1512/31/20

Project: Research projectResearch Project

Chlorthalidone
Chronic Renal Insufficiency
Sodium Chloride Symporter Inhibitors
Blood Pressure
Thiazides

The role of the urethral microbiome in idiopathic urethritis in men

Batteiger, B. & Nelson, D. E.

National Institutes of Health

12/1/1511/30/20

Project: Research projectResearch Project

Urethritis
Microbiota
Mycoplasma genitalium
Dysbiosis
Ureaplasma urealyticum

Brain Health Patient Safety Learning Laboratory

Callahan, C.

National Institutes of Health

9/30/159/29/19

Project: Research projectCenter Core Grants

Patient Safety
Learning
Health
Brain
Safety

Prefrontal circuitry and pain

Sheets, P.

National Institutes of Health

9/30/156/30/20

Project: Research projectResearch Project

Neuralgia
Periaqueductal Gray
Prefrontal Cortex
Pain
Optogenetics

NINDS Biomarker Repository

Foroud, T.

National Institutes of Health

9/30/159/29/20

Project: Research projectResource-Related Research Projects--Cooperative Agreements

National Institute of Neurological Disorders and Stroke
Biomarkers
Aptitude
Parkinson Disease
Alzheimer Disease

Central and Peripheral Roles of TREM2 in Alzheimer's Disease

Lamb, B.

National Institutes of Health

9/30/158/31/20

Project: Research projectMulti-Year Funded Research Project Grant

Alzheimer Disease
Myeloid Cells
Pathology
Brain
Microglia
Pre-Eclampsia
Blood Vessels
Lung
Stem Cells
Vascular Endothelial Growth Factor A
Neurofibromatosis 1
Plexiform Neurofibroma
Neoplasms
Therapeutics
Respiratory Function Tests
Nursing
Physicians
Therapeutics
Palliative Care
Geriatrics

Developmental and HyperActive Ras Tumor SPORE

Clapp, D., Shannon, K. M., Nakamura, J., Skapek, S. & Johnson, G. L.

National Institutes of Health

9/1/158/31/20

Project: Research projectSpecialized Center--Cooperative Agreements

Plexiform Neurofibroma
Neurofibromatosis 1
Neoplasms
Molecular Biology
Clinical Trials

Iron Therapy for Autosomal Dominant Hypophosphatemic Rickets: A Pilot Project

Econs, M.

National Institutes of Health

9/1/158/31/18

Project: Research projectExploratory/Developmental Grants

Iron
Therapeutics
Autosomal Dominant Hypophosphatemic Rickets
Serum
Phosphates

7/8 NADIA UO1 Adolescent Alcohol and Neurocircuitry Mediating Ethanol Reinforcement

Rodd, Z.

National Institutes of Health

9/1/158/31/20

Project: Research projectResearch Project--Cooperative Agreements

Ethanol
Alcohols
Ventral Tegmental Area
Histone Deacetylase Inhibitors
Anti-Anxiety Agents
Humoral Immunity
Cellular Immunity
Human Influenza
Vaccination
Cytotoxic T-Lymphocytes

Neurobiological Role of MicroRNA in Alzheimer's

Lahiri, D.

National Institutes of Health

9/1/154/30/20

Project: Research projectResearch Project

MicroRNAs
Alzheimer Disease
Protein Precursors
Amyloid
Peptides

LXR as a novel therapeutic target in diabetic retinopathy

Grant, M., Boulton, M. & Busik, J.

National Institutes of Health

9/1/158/31/19

Project: Research projectResearch Project

Diabetic Retinopathy
Blood Vessels
Lipids
Retina
Monocytes