Project: Research project

Project Details


Although it is now well accepted that the primary anticaries
activity of fluoride (F) is via topical action, the importance of F
retention in the mouth has not been elucidated. The intent of this
proposal is to study the relationship between F retention in the
oral cavity and the clinical efficacy of home-use topical F
products. In the first phase of the project F concentrations in
whole saliva, ductal saliva, plaque, enamel, soft tissue and
interproximal spaces will be determined at different intervals
after the application of topical F products (F-dentifrice, F-
mouthrinse, F-gel). Four subject panels will be compared: a
standardized panel of dentally healthy adults; an edentulous panel;
a periodontally involved panel; and an hyposalivatory panel. In
the second phase of the project the standardized subject panel
will wear an intraoral appliance carrying partially demineralized
blocks of human enamel. Enamel remineralization and F-uptake
will be evaluated after 1, 7 and 14 days of treatment with
different F regimens. Experiments will be conducted to separate
the effects of initial F exposure during topical F application from
the effects of F-retention in the mouth after the initial
application. Additional experiments will evaluate the effects of
daytime vs. nighttime F treatment. The objectives of the study are: a) to compare F concentrations
in whole saliva with ductal saliva, plaque, enamel, oral soft tissue
and interproximal spaces after the use of different home-use F
regimens; b) to compare a standardized subject panel with an
edentulous panel, a periodontally involved panel, and an
hyposalivatory panel, in regard to F-retention. (c) to evaluate the
relationship between F-retention, and enamel remineralization
and F-uptake over periods of 1, 7 and 14 days; (d) to compare
remineralizing effect of the initial contact of topical F with teeth
with the effect of F retained in the oral environment after F
treatment. The proposed research is expected to provide a deeper
understanding of fluoride retention, its role in the caries process,
and how this can be exploited to improve caries preventive
Effective start/end date7/1/889/29/96


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)
  • Dentistry(all)

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