Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease

Project: Research projectResearch Project

Description

PROJECT SUMMARY Both alcoholic and non-alcoholic fatty liver diseases (AFLD and NAFLD, respectively) causeserious health problems in the US. AFLD occurs in nearly all excessive alcohol drinkers and NAFLDafflicts approximately one-third of adult population. Worse yet, there is no effective treatment for eitherAFLD or NAFLD at this time. In this proposed research, we plan to investigate molecular mechanismsof Sestrin3 (Sesn3) in the regulation of hepatic lipid metabolism. There are two specific aims in thisproject. Aim# 1 is to determine the protective mechanism of Sesn3 against AFLD and NAFLD throughthe Atg14-regulated autophagy pathway. Aim #2 is to examine the role of Sesn3-mTORC2 pathway inthe pathogenesis of AFLD and NAFLD. It is anticipated that the findings from this proposed researchshould provide valuable information for therapeutic development to treat AFLD and NAFLD.
StatusActive
Effective start/end date7/1/166/30/20

Funding

  • National Institutes of Health: $345,956.00

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Autophagy
Lipid Metabolism
Non-alcoholic Fatty Liver Disease
Alcohols
Liver
Health
Research
Population
Therapeutics
TOR complex 2