Project: Research project

Project Details


The proposed Alzheimer's Disease Research center (ADRC) will be
built on existing individual expertise and institutional commitment
to the study of Alzheimer's disease (AD), clinical care of
patients, and the dissemination of knowledge concerning this
devastating disorder. University Hospitals of Cleveland (UHC) and
Case Western Reserve University (CWRU) support an Alzheimer Center
that coordinates research, clinical care, and educational programs
in AD. Our proposed ADRC will examine the functional importance
abnormalities occurring in AD ranging from molecular biology to
activities of daily living. Emphasis will be placed on
understanding inter-relationships between different levels of
scientific inquiry, i.e. how do changes in messenger RNA relate to
cell dysfunction; how does cell dysfunction relate to cognitive
impairment; and how does cognitive impairment convert to functional
disability? The proposed ADRC will be organized around five cores:
1) Administrative, 2) Clinical (including a patient registry and
a data management and analysis component), 3) Research Training and
Information Transfer Core (Education Core), 4) Imaging Core, and
5) Neuropathology Core. Three research projects will be added to
the already existing research program: 1) Vessels of the Brain
Aging and AD (Harik/Kalaria), 2) Characterization of Amyloid in AD
(Younkin), 3) Functional Communication Decline in AD (Ripich). In
addition, we propose several pilot research projects which will be
built on our already existing pilot grant research program.
Studies proposed for year one include: Immunostain Fingerprints
of the Neural Tissue (Caplan), PHF Binding Proteins (Perry), and
Socially Desirable Response Tendency and Caregiver Burden (Smyth).
Second year proposal include: Physicians' Attitudes and Practices
toward AD Patients (Kahana), ADL skills and Cognitive Status in AD
(Martin), Higher Visual Functions in AD (Mendez), and Black and
White Caregivers of Elders with Dementia (Wykle/Segall). The proposed ADRC will permit an already cohesive, nationally
recognized group of investigators to continue making major
contributions to understanding this disorder, converting this
understanding into improved clinical care, and educating lay
groups, professionals, and policy makers--both locally and
nationally--concerning this devastating disease.
Effective start/end date9/21/885/31/07


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


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