Find Publications

2019

Changes in bone matrix properties with aging

Burr, D., Mar 1 2019, In : Bone. 120, p. 85-93 9 p.

Research output: Contribution to journalArticle

Bone Matrix
Bone and Bones
Minerals
Collagen
Bone Remodeling

Childhood poverty and the organization of structural brain connectome

Kim, D. J., Davis, E. P., Sandman, C. A., Glynn, L., Sporns, O., O'Donnell, B. & Hetrick, W. P., Jan 1 2019, In : NeuroImage. 184, p. 409-416 8 p.

Research output: Contribution to journalArticle

Connectome
Poverty
Organizations
Brain
Amygdala

Clinical Outcomes After Ileal Pouch-Anal Anastomosis in Pediatric Patients

Huang, C. C., Rescorla, F. & Landman, M. P., Feb 1 2019, In : Journal of Surgical Research. 234, p. 72-76 5 p.

Research output: Contribution to journalArticle

Colonic Pouches
Adenomatous Polyposis Coli
Pediatrics
Ulcerative Colitis
Pouchitis

Constructing kinetically controlled denaturation isotherms of folded proteins using denaturant-pulse chaperonin binding

O’Neil, P. T., Machen, A. J., Thompson, J. A., Wang, W., Hoang, Q., Baldwin, M. R., Khar, K. R., Karanicolas, J. & Fisher, M. T., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 293-304 12 p. (Methods in Molecular Biology; vol. 1873).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chaperonins
Immobilized Proteins
Protein Unfolding
Proteins
Protein Stability

Developing an adaptive mobile platform in family medicine field experiences: User perceptions

Rogers, C., Renguette, C., Cooper, S., Renshaw, S., Seig, M. T. & Schnepp, J., Jan 1 2019, Smart Education and e-Learning, 2018. Springer Science and Business Media Deutschland GmbH, p. 37-50 14 p. (Smart Innovation, Systems and Technologies; vol. 99).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Medicine
Students
Education
Health care
User experience
2018

(-)-phenserine and inhibiting pre-programmed cell death: In pursuit of a novel intervention for Alzheimer’s disease

Becker, R. E., Greig, N. H., Lahiri, D., Bledsoe, J., Majercik, S., Ballard, C., Aarsland, D., Schneider, L. S., Flanagan, D., Govindarajan, R., Sano, M., Ferrucci, L. & Kapogiannis, D., Jan 1 2018, In : Current Alzheimer Research. 15, 9, p. 883-891 9 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Cell Death
Clinical Trials
Animal Models
phenserine

1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor

Kjalarsdottir, L., Tersey, S. A., Vishwanath, M., Chuang, J. C., Posner, B. A., Mirmira, R. & Repa, J. J., Jan 1 2018, (Accepted/In press) In : Journal of Steroid Biochemistry and Molecular Biology.

Research output: Contribution to journalArticle

Calcitriol Receptors
Calcitriol
Calcium Channels
Insulin
Glucose

18F-NaF and 18F-FDG as molecular probes in the evaluation of atherosclerosis

McKenney-Drake, M. L., Moghbel, M. C., Paydary, K., Alloosh, M., Houshmand, S., Moe, S., Salavati, A., Sturek, J. M., Territo, P., Weaver, C., Werner, T. J., Høilund-Carlsen, P. F., Sturek, M. & Alavi, A., Jul 6 2018, (Accepted/In press) In : European Journal of Nuclear Medicine and Molecular Imaging. p. 1-11 11 p.

Research output: Contribution to journalArticle

Molecular Probes
Fluorodeoxyglucose F18
Positron-Emission Tomography
Atherosclerosis
Vascular Calcification
22 Citations

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Calkins, H., Hindricks, G., Cappato, R., Kim, Y. H., Saad, E. B., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, J., Chen, P-S., Chen, S. A., Chung, M. K., Cosedis Nielsen, J., Curtis, A. B., Davies, D. W., Day, J. D., D'Avila, AE., Natasja De Groot, N. M. S., Di Biase, L. & 40 othersDuytschaever, M., Edgerton, J. R., Ellenbogen, K. A., Ellinor, P. T., Ernst, S., Fenelon, G., Gerstenfeld, E. P., Haines, D. E., Haissaguerre, M., Helm, R. H., Hylek, E., Jackman, W. M., Jalife, J., Kalman, J. M., Kautzner, J., Kottkamp, H., Kuck, K. H., Kumagai, K., Lee, R., Lewalter, T., Lindsay, B. D., MacLe, L., Mansour, M., Marchlinski, F. E., Michaud, G. F., Nakagawa, H., Natale, A., Nattel, S., Okumura, K., Packer, D., Pokushalov, E., Reynolds, M. R., Sanders, P., Scanavacca, M., Schilling, R., Tondo, C., Tsao, H. M., Verma, A., Wilber, D. J. & Yamane, T., Jan 1 2018, In : Europace. 20, 1, p. 157-208 52 p.

Research output: Contribution to journalArticle

Atrial Flutter
Catheter Ablation
Atrial Fibrillation
Cardiac Arrhythmias
Stroke
9 Citations

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Calkins, H., Hindricks, G., Cappato, R., Kim, Y. H., Saad, E. B., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, J., Chen, P-S., Chen, S. A., Chung, M. K., Cosedis Nielsen, J., Curtis, A. B., Davies, D. W., Day, J. D., D'Avila, AE., Natasja De Groot, N. M. S., Di Biase, L. & 50 othersDuytschaever, M., Edgerton, J. R., Ellenbogen, K. A., Ellinor, P. T., Ernst, S., Fenelon, G., Gerstenfeld, E. P., Haines, D. E., Haissaguerre, M., Helm, R. H., Hylek, E., Jackman, W. M., Jalife, J., Kalman, J. M., Kautzner, J., Kottkamp, H., Kuck, K. H., Kumagai, K., Lee, R., Lewalter, T., Lindsay, B. D., MacLe, L., Mansour, M., Marchlinski, F. E., Michaud, G. F., Nakagawa, H., Natale, A., Nattel, S., Okumura, K., Packer, D., Pokushalov, E., Reynolds, M. R., Sanders, P., Scanavacca, M., Schilling, R., Tondo, C., Tsao, H. M., Verma, A., Wilber, D. J., Yamane, T., Blomström-Lundqvist, C., De Paola, A. A. V., Kistler, P. M., Lip, G. Y. H., Peters, N. S., Pisani, C. F., Raviele, A., Satomi, K., Stiles, M. K. & Willems, S., Jan 1 2018, In : Europace. 20, 1, p. e1-e160

Research output: Contribution to journalArticle

Atrial Flutter
Catheter Ablation
Atrial Fibrillation
Cardiac Arrhythmias
Stroke

2017 Riley Heart Center Symposium on Cardiac Development: Development and Repair of the Ventricular Wall

Field, L., Shou, W. & Markham, L., Aug 1 2018, In : Pediatric Cardiology. 39, 6, p. 1067-1068 2 p.

Research output: Contribution to journalArticle

2018—Changing Times for CRBM

Allen, M., Feb 7 2018, (Accepted/In press) In : Clinical Reviews in Bone and Mineral Metabolism. p. 1-2 2 p.

Research output: Contribution to journalArticle

1 Citations

24-Month Overall Survival from KEYNOTE-021 Cohort G: Pemetrexed and Carboplatin with or without Pembrolizumab as First-Line Therapy for Advanced Nonsquamous Non–Small Cell Lung Cancer

Borghaei, H., Langer, C. J., Gadgeel, S., Papadimitrakopoulou, V. A., Patnaik, A., Powell, S. F., Gentzler, R. D., Martins, R. G., Stevenson, J. P., Jalal, S., Panwalkar, A., Chih-Hsin Yang, J., Gubens, M., Sequist, L. V., Awad, M. M., Fiore, J., Saraf, S., Keller, S. M. & Gandhi, L., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Survival
Therapeutics
3 Citations

3,4-diaminopyridine base effectively treats the weakness of Lambert-Eaton myasthenia

Sanders, D. B., Juel, V. C., Harati, Y., Smith, A. G., Peltier, A. C., Marburger, T., Lou, J. S., Pascuzzi, R., Richman, D. P., Xie, T., Demmel, V., Jacobus, L. R., Aleš, K. L. & Jacobus, D. P., Jan 1 2018, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

Placebos
Maintenance
3,4-diaminopyridine
Pharmaceutical Preparations
Therapeutics
2 Citations

3D-Image analysis of the impact of toothpaste abrasivity on the progression of simulated non-carious cervical lesions

Sabrah, A. H., Turssi, C. P., Lippert, F., Eckert, G. J., Kelly, A. B. & Hara, A., Jan 1 2018, (Accepted/In press) In : Journal of Dentistry.

Research output: Contribution to journalArticle

Toothpastes
Dentin
Dentifrices
Toothbrushing
Acrylic Resins

50 Years Ago in THE JOURNAL OF PEDIATRICS: Spurious Heart Disease in Athletic Children

Ott, M., May 1 2018, In : Journal of Pediatrics. 196, 1 p.

Research output: Contribution to journalArticle

Sports
Heart Diseases
1 Citations

A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism

Schuckit, M. A., Smith, T. L., Danko, G., Kramer, J., Bucholz, K. K., Mccutcheon, V., Chan, G., Kuperman, S., Hesselbrock, V., Dick, D. M., Hesselbrock, M., Porjesz, B., Edenberg, H., Nureberger, J. I., Gregg, M., Schoen, L., Kawamura, M. & Mendoza, L. A., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Genetics
Drinking
Street Drugs

A Balancing Act: PGRPs Preserve and Protect

Dziarski, R. & Gupta, D., Feb 14 2018, In : Cell host & microbe. 23, 2, p. 149-151 3 p.

Research output: Contribution to journalComment/debate

amidase
Peptidoglycan
Microbiota
Drosophila
Immune System

Abbreviated dignity therapy for adults with advanced-stage cancer and their family caregivers: Qualitative analysis of a pilot study

Beck, A., Cottingham, A. H., Stutz, P. V., Gruber, R., Bernat, J. K., Helft, P., Wilhelm, L., Schmidt, K., Stout, M. E., Willard, C. & Johns, S., Jan 1 2018, (Accepted/In press) In : Palliative and Supportive Care.

Research output: Contribution to journalArticle

Caregivers
Interviews
Terminally Ill
Neoplasms
Ego
Hemorrhage
Mortality
Survivors
Bleeding Time
Cohort Studies

A behavioral rating system predicts weight loss and quality of life after bariatric surgery

Hilgendorf, W., Butler, A., Timsina, L., Choi, J., Banerjee, A., Selzer, D. & Stefanidis, D., Jan 1 2018, (Accepted/In press) In : Surgery for Obesity and Related Diseases.

Research output: Contribution to journalArticle

Bariatric Surgery
Weight Loss
Quality of Life
Anxiety
Depression

Aberrant structural–functional coupling in adult cannabis users

Kim, D. J., Schnakenberg Martin, A. M., Shin, Y. W., Jo, H. J., Cheng, H., Newman, S. D., Sporns, O., Hetrick, W. P., Calkins, E. & O'Donnell, B., Jan 1 2018, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

Cannabis
Hippocampus
Cannabinoid Receptor CB1
Endocannabinoids
Neuronal Plasticity
3 Citations

A Biomarker Characterizing Neurodevelopment with applications in Autism

Wu, D., José, J. V., Nurnberger, J. & Torres, E. B., Dec 1 2018, In : Scientific Reports. 8, 1, 614.

Research output: Contribution to journalArticle

Autistic Disorder
Biomarkers
Electromagnetic Phenomena
Coordination Complexes
Neurosciences

A Brief Critique of the TATES Procedure

Aliev, F., Salvatore, J. E., Agrawal, A., Almasy, L., Chan, G., Edenberg, H., Hesselbrock, V., Kuperman, S., Meyers, J. & Dick, D. M., Mar 1 2018, In : Behavior Genetics. 48, 2, p. 155-167 13 p.

Research output: Contribution to journalArticle

phenotype
inflation
Phenotype
Genome-Wide Association Study
Economic Inflation
8 Citations

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

Cornetta, K., Duffy, L., Turtle, C. J., Jensen, M., Forman, S., Binder-Scholl, G., Fry, T., Chew, A., Maloney, D. G. & June, C. H., Jan 3 2018, In : Molecular Therapy. 26, 1, p. 280-288 9 p.

Research output: Contribution to journalArticle

Lentivirus
T-Lymphocytes
Safety
Genetic Therapy
Lentivirus Infections

Academic versus Clinical Productivity of (Elite) United States transplant surgeons: who publishes more and who operates more

Rosati, C. M., Koniaris, L., Gaudino, M., Milgrom, D. P., Girardi, L. N. & Ekser, B., Jan 1 2018, In : American Surgeon. 84, 1, p. E36-E38

Research output: Contribution to journalLetter

Transplants
Surgeons

Academic versus clinical productivity of cardiac surgeons in the state of New York: Who publishes more and who operates more

Rosati, C. M., Gaudino, M., Vardas, P. N., Weber, D. J., Blitzer, D., Hameedi, F., Koniaris, L. & Girardi, L. N., Jan 1 2018, In : American Surgeon. 84, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Publications
Thoracic Surgery
Surgeons
Databases
Population
Hepatopulmonary Syndrome
Hereditary Hemorrhagic Telangiectasia
Arteriovenous Malformations
Lung
Portal Hypertension
1 Citations

A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine

Del Vecchio, K., Frick, C. T., Gc, J. B., Oda, S. I., Gerstman, B. S., Saphire, E. O., Chapagain, P. P. & Stahelin, R., Jan 1 2018, In : Journal of Biological Chemistry. 293, 9, p. 3335-3349 15 p.

Research output: Contribution to journalArticle

Viral Matrix Proteins
Ebolavirus
Phosphatidylserines
Viral Proteins
Viruses
1 Citations

Acceptability and results of dementia screening among older adults in the United States

Harrawood, A., Fowler, N., Perkins, A. J., LaMantia, M. A. & Boustani, M., Jan 1 2018, In : Current Alzheimer Research. 15, 1, p. 51-55 5 p.

Research output: Contribution to journalArticle

Dementia
Primary Health Care
Sex Education
Telephone
Cross-Sectional Studies
1 Citations

Acceptability of a telecare intervention for persistent musculoskeletal pain

Guilkey, R. E., Draucker, C., Wu, J., Yu, Z. & Kroenke, K., Jan 1 2018, In : Journal of Telemedicine and Telecare. 24, 1, p. 44-50 7 p.

Research output: Contribution to journalArticle

Musculoskeletal Pain
Nurses
Pain
Text Messaging
Patient Satisfaction

Acceptance and commitment therapy for symptom interference in metastatic breast cancer patients: a pilot randomized trial

Mosher, C. E., Secinti, E., Li, R., Hirsh, A. T., Bricker, J., Miller, K., Schneider, B., Storniolo, A. M., Mina, L., Newton, E. V., Champion, V. & Johns, S., Jan 12 2018, (Accepted/In press) In : Supportive Care in Cancer. p. 1-12 12 p.

Research output: Contribution to journalArticle

Acceptance and Commitment Therapy
Fatigue
Breast Neoplasms
Sleep
Telephone

Access to antiretroviral therapy in HIV-infected children aged 0–19 years in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Global Cohort Consortium, 2004–2015: A prospective cohort study

for the International Epidemiology Databases to Evaluate AIDS (IeDEA) Pediatric Working Group, May 1 2018, In : PLoS Medicine. 15, 5, e1002565.

Research output: Contribution to journalArticle

Acquired Immunodeficiency Syndrome
Epidemiology
Cohort Studies
HIV
Databases

Accuracy of a Fourth-Generation Continuous Glucose Monitoring System in Children and Adolescents with Type 1 Diabetes

Slover, R. H., Tryggestad, J. B., DiMeglio, L., Fox, L. A., Bode, B. W., Bailey, T. S., Brazg, R., Christiansen, M. P., Sherr, J. L., Tsalikian, E., Kaiserman, K. B., Sullivan, A., Huang, S., Shin, J., Lee, S. W. & Kaufman, F. R., Sep 1 2018, In : Diabetes Technology and Therapeutics. 20, 9, p. 576-584 9 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Glucose
Blood Glucose Self-Monitoring
Reference Values
Equipment and Supplies
Dental Models
Synthetic Resins
Surgical Casts
Technology
Orthodontics

Achieving More Natural Motion, Stability, and Function with a Dual-Pivot ACL-substituting Total Knee Arthroplasty Design

Banks, S. A. & Meneghini, R., Jan 1 2018, In : Techniques in Orthopaedics. 33, 1, p. 48-51 4 p.

Research output: Contribution to journalArticle

Knee Replacement Arthroplasties
Anterior Cruciate Ligament
Knee
Biomechanical Phenomena
Walking

A cognitive systems engineering design approach to improve the usability of electronic order forms for medical consultation

Savoy, A., Militello, L. G., Patel, H., Flanagan, M. E., Russ, A. L., Daggy, J., Weiner, M. & Saleem, J. J., Sep 1 2018, In : Journal of Biomedical Informatics. 85, p. 138-148 11 p.

Research output: Contribution to journalArticle

Cognitive systems
Systems engineering
Referral and Consultation
Medical Electronics
User interfaces
2 Citations

A Collaborative In Situ Simulation-based Pediatric Readiness Improvement Program for Community Emergency Departments

Abulebda, K., Lutfi, R., Whitfill, T., Abu-Sultaneh, S., Leeper, K. J., Weinstein, E. & Auerbach, M. A., Feb 1 2018, In : Academic Emergency Medicine. 25, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

Hospital Emergency Service
Pediatrics
Diabetic Ketoacidosis
Supraventricular Tachycardia
Respiratory Insufficiency

A comparison between two approaches to identify opioid use problems: ICD-9 vs. Text-mining approach

Alzeer, A. H., Patel, J., Dixon, B. E., Jones, J. F. & Bair, M., Jul 24 2018, Proceedings - 2018 IEEE International Conference on Healthcare Informatics, ICHI 2018. Institute of Electrical and Electronics Engineers Inc., p. 455-456 2 p. 8419433

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Data Mining
International Classification of Diseases
Opioid Analgesics
Incidence
Research

A Comparison of Error Rates between Intravenous Push Methods: A Prospective, Multisite, Observational Study

Hertig, J. B., Degnan, D. D., Scott, C. R., Lenz, J. R., Li, X. & Anderson, C. M., Mar 1 2018, In : Journal of Patient Safety. 14, 1, p. 60-65 6 p.

Research output: Contribution to journalArticle

Syringes
Intravenous Administration
Observational Studies
Research Personnel
Patient Harm

A Comparison of Simple Analytical Methods for Determination of Fluoride in Microlitre-Volume Plasma Samples

Zohoori, F. V., Maguire, A., Martinez Mier, E., Buzalaf, M. A. R., Sanderson, R. & Eckert, G. J., Jan 1 2018, (Accepted/In press) In : Caries research. p. 275-283 9 p.

Research output: Contribution to journalArticle

Plasma Volume
Fluorides
Analysis of Variance

A comprehensive anatomical characterization and radiographic study of stage III testicular cancer in a 31-year-old male patient

Talarico, E., Mas, J. L. & Jones, J. A., May 1 2018, In : European Journal of Anatomy. 22, 3, p. 241-256 16 p.

Research output: Contribution to journalArticle

Testicular Neoplasms
Dissection
Neoplasms
Hepatomegaly
Lung

A comprehensive review and meta-analysis of risk factors for statin-induced myopathy

Nguyen, K. A., Li, L., Lu, D., Yazdanparast, A., Wang, L., Kreutz, R., Whipple, E. C. & Schleyer, T., May 22 2018, (Accepted/In press) In : European Journal of Clinical Pharmacology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscular Diseases
Meta-Analysis
Cardiovascular Diseases
Rhabdomyolysis

A computable pathology report for precision medicine: Extending an observables ontology unifying SNOMED CT and LOINC

Campbell, W. S., Karlsson, D., Vreeman, D., Lazenby, A. J., Talmon, G. A. & Campbell, J. R., Mar 1 2018, In : Journal of the American Medical Informatics Association. 25, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

Logical Observation Identifiers Names and Codes
Systematized Nomenclature of Medicine
Precision Medicine
Pathology
Terminology

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Jun 25 2018, In : BMC Genomics. 19, 1, 494.

Research output: Contribution to journalArticle

Genome-Wide Association Study

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., Mar 6 2018, (Accepted/In press) In : Journal of Medical Economics. p. 1-12 12 p.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Cost-Benefit Analysis
Costs and Cost Analysis
Disease-Free Survival

Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

Osman, H., Elsahy, D., Saadatzadeh, M. R., Pollok, K., Yocom, S., Hattab, E. M., Georges, J. & Cohen-Gadol, A., Jun 1 2018, In : World Neurosurgery. 114, p. e1310-e1315

Research output: Contribution to journalArticle

Acridine Orange
Photosensitizing Agents
Photochemotherapy
Glioblastoma
Light

A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System

Venkatasubramaniam, A., Kanipakala, T., Ganjbaksh, N., Mehr, R., Mukherjee, I., Krishnan, S., Bae, T., Aman, M. J. & Adhikari, R. P., Sep 18 2018, In : Toxins. 10, 9

Research output: Contribution to journalArticle

Staphylococcus aureus
Erythrocytes
Hemolysin Proteins
Vaccines
Gene Knockout Techniques

Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections

Mlodzianoski, M. J., Cheng-Hathaway, P. J., Bemiller, S. M., McCray, T. J., Liu, S., Miller, D. A., Lamb, B., Landreth, G. E. & Huang, F., Jul 16 2018, (Accepted/In press) In : Nature Methods. p. 1-4 4 p.

Research output: Contribution to journalArticle

Adaptive optics
Amyloid
Microscopy
Brain
Microscopic examination