β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

Yukiko Kitase, Julian A. Vallejo, William Gutheil, Harika Vemula, Katharina Jähn, Jianxun Yi, Jingsong Zhou, Marco Brotto, Lynda Bonewald

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). L-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging. Kitase et al. show that the muscle-derived factor L-BAIBA signals through the MRGPRD to prevent osteocyte cell death induced by reactive oxygen species, a function lost with aging.

Original languageEnglish (US)
Pages (from-to)1531-1544
Number of pages14
JournalCell Reports
Volume22
Issue number6
DOIs
StatePublished - Feb 6 2018

Fingerprint

Aminoisobutyric Acids
Osteocytes
Muscle
Reactive Oxygen Species
Muscles
Bone
Aging of materials
Cell death
G-Protein-Coupled Receptors
Bone and Bones
Cell Death
Acetylcysteine
Hindlimb Suspension
White Adipose Tissue
Mitochondria
Unloading
Metabolism
Drinking Water
Cysteine
Insulin Resistance

Keywords

  • aging
  • BAIBA
  • bone-muscle crosstalk
  • hindlimb unloading
  • Mas-related G protein-coupled receptor type D
  • mitochondria
  • osteocyte
  • reactive oxygen species
  • viability
  • β-aminoisobutyric acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. / Kitase, Yukiko; Vallejo, Julian A.; Gutheil, William; Vemula, Harika; Jähn, Katharina; Yi, Jianxun; Zhou, Jingsong; Brotto, Marco; Bonewald, Lynda.

In: Cell Reports, Vol. 22, No. 6, 06.02.2018, p. 1531-1544.

Research output: Contribution to journalArticle

Kitase, Y, Vallejo, JA, Gutheil, W, Vemula, H, Jähn, K, Yi, J, Zhou, J, Brotto, M & Bonewald, L 2018, 'β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor', Cell Reports, vol. 22, no. 6, pp. 1531-1544. https://doi.org/10.1016/j.celrep.2018.01.041
Kitase Y, Vallejo JA, Gutheil W, Vemula H, Jähn K, Yi J et al. β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. Cell Reports. 2018 Feb 6;22(6):1531-1544. https://doi.org/10.1016/j.celrep.2018.01.041
Kitase, Yukiko ; Vallejo, Julian A. ; Gutheil, William ; Vemula, Harika ; Jähn, Katharina ; Yi, Jianxun ; Zhou, Jingsong ; Brotto, Marco ; Bonewald, Lynda. / β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. In: Cell Reports. 2018 ; Vol. 22, No. 6. pp. 1531-1544.
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