β-Cell autoimmunity in overweight non-diabetic youth: Any implications?

Ingrid M. Libman, E. Barinas-Mitchell, S. Marcovina, F. Bacha, T. Hannon, H. Tfayli, Sj Lee, S. Bansal, R. Robertson, S. Arslanian

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background and objective: The presence of β-cell antibodies is associated with a high risk of type 1 diabetes. With increasing rates of obesity, the distinction between obese T1DM and T2DM has become difficult. Moreover, increasing body mass index (BMI) in at-risk children has been proposed not only as a possible contributor to T1DM by increasing insulin resistance, but also as exerting an effect via the immunomodulatory properties of certain adipokines. This study aimed to determine prevalence of β-cell autoantibodies (AA) in overweight non-diabetic children and assess insulin sensitivity and secretion derived from an oral glucose tolerance test (OGTT) in those with vs. without ß-cell AA. Research design and methods: A total of 357 overweight (BMI > 85%) youths underwent OGTTs, dual energy X-ray absorptiometry (DEXA) and measurement of GAD65 and IA-2 AA according to the NIDDK harmonization assay. Using the same methodology, AA were measured in 90 normal weight, non-diabetic individuals. Results: About 1.9% of overweight and 4.4% of control normal weight children had evidence of β-cell autoimmunity, with GAD65 AA detected in all subjects but none with IA-2. Youth with positive vs. those with negative AA had higher leptin/adiponectin ratio, glucose at 60 min and C-peptide at 90 min. Conclusions: These findings suggest that the prevalence of β-cell AA in overweight youth may be similar to that in non-overweight children. Further studies using standardized methods are required.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalPediatric Diabetes
Volume12
Issue number3 PART 2
DOIs
StatePublished - May 2011

Keywords

  • Autoimmunity
  • Children
  • Obesity
  • ß-cell antibodies

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

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    Libman, I. M., Barinas-Mitchell, E., Marcovina, S., Bacha, F., Hannon, T., Tfayli, H., Lee, S., Bansal, S., Robertson, R., & Arslanian, S. (2011). β-Cell autoimmunity in overweight non-diabetic youth: Any implications? Pediatric Diabetes, 12(3 PART 2), 207-211. https://doi.org/10.1111/j.1399-5448.2010.00697.x