β-Cell autoimmunity in overweight non-diabetic youth

Any implications?

Ingrid M. Libman, E. Barinas-Mitchell, S. Marcovina, F. Bacha, Tamara Hannon, H. Tfayli, Sj Lee, S. Bansal, R. Robertson, S. Arslanian

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and objective: The presence of β-cell antibodies is associated with a high risk of type 1 diabetes. With increasing rates of obesity, the distinction between obese T1DM and T2DM has become difficult. Moreover, increasing body mass index (BMI) in at-risk children has been proposed not only as a possible contributor to T1DM by increasing insulin resistance, but also as exerting an effect via the immunomodulatory properties of certain adipokines. This study aimed to determine prevalence of β-cell autoantibodies (AA) in overweight non-diabetic children and assess insulin sensitivity and secretion derived from an oral glucose tolerance test (OGTT) in those with vs. without ß-cell AA. Research design and methods: A total of 357 overweight (BMI > 85%) youths underwent OGTTs, dual energy X-ray absorptiometry (DEXA) and measurement of GAD65 and IA-2 AA according to the NIDDK harmonization assay. Using the same methodology, AA were measured in 90 normal weight, non-diabetic individuals. Results: About 1.9% of overweight and 4.4% of control normal weight children had evidence of β-cell autoimmunity, with GAD65 AA detected in all subjects but none with IA-2. Youth with positive vs. those with negative AA had higher leptin/adiponectin ratio, glucose at 60 min and C-peptide at 90 min. Conclusions: These findings suggest that the prevalence of β-cell AA in overweight youth may be similar to that in non-overweight children. Further studies using standardized methods are required.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalPediatric Diabetes
Volume12
Issue number3 PART 2
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Autoimmunity
Autoantibodies
Glucose Tolerance Test
Insulin Resistance
Body Mass Index
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Weights and Measures
Adipokines
C-Peptide
Adiponectin
Photon Absorptiometry
Leptin
Type 1 Diabetes Mellitus
Research Design
Obesity
Glucose
Antibodies

Keywords

  • ß-cell antibodies
  • Autoimmunity
  • Children
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Libman, I. M., Barinas-Mitchell, E., Marcovina, S., Bacha, F., Hannon, T., Tfayli, H., ... Arslanian, S. (2011). β-Cell autoimmunity in overweight non-diabetic youth: Any implications? Pediatric Diabetes, 12(3 PART 2), 207-211. https://doi.org/10.1111/j.1399-5448.2010.00697.x

β-Cell autoimmunity in overweight non-diabetic youth : Any implications? / Libman, Ingrid M.; Barinas-Mitchell, E.; Marcovina, S.; Bacha, F.; Hannon, Tamara; Tfayli, H.; Lee, Sj; Bansal, S.; Robertson, R.; Arslanian, S.

In: Pediatric Diabetes, Vol. 12, No. 3 PART 2, 05.2011, p. 207-211.

Research output: Contribution to journalArticle

Libman, IM, Barinas-Mitchell, E, Marcovina, S, Bacha, F, Hannon, T, Tfayli, H, Lee, S, Bansal, S, Robertson, R & Arslanian, S 2011, 'β-Cell autoimmunity in overweight non-diabetic youth: Any implications?', Pediatric Diabetes, vol. 12, no. 3 PART 2, pp. 207-211. https://doi.org/10.1111/j.1399-5448.2010.00697.x
Libman IM, Barinas-Mitchell E, Marcovina S, Bacha F, Hannon T, Tfayli H et al. β-Cell autoimmunity in overweight non-diabetic youth: Any implications? Pediatric Diabetes. 2011 May;12(3 PART 2):207-211. https://doi.org/10.1111/j.1399-5448.2010.00697.x
Libman, Ingrid M. ; Barinas-Mitchell, E. ; Marcovina, S. ; Bacha, F. ; Hannon, Tamara ; Tfayli, H. ; Lee, Sj ; Bansal, S. ; Robertson, R. ; Arslanian, S. / β-Cell autoimmunity in overweight non-diabetic youth : Any implications?. In: Pediatric Diabetes. 2011 ; Vol. 12, No. 3 PART 2. pp. 207-211.
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