14-3-3σ, the double-edged sword of human cancers

Zhaomin Li, Jing Yuan Liu, Jian-Ting Zhang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3σ has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3-3σ may also predict poor prognosis in some human cancers. Thus, 14-3-3σ may play an important role as a double-edged sword in human cancers, which may attribute to its property as a molecular chaperone by binding to various protein ligands important to many cellular processes such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will review recent studies and progresses in understanding 14-3-3σ as a double-edged sword in human cancers.

Original languageEnglish
Pages (from-to)326-340
Number of pages15
JournalAmerican Journal of Translational Research
Volume1
Issue number4
StatePublished - 2009

Fingerprint

14-3-3 Proteins
Molecular Chaperones
DNA
Antineoplastic Agents
Tumors
Neoplasms
Cells
DNA Damage
Apoptosis
Ligands
Radiation
Cell Cycle Checkpoints
Proteins

Keywords

  • 14-3-3σ
  • Drug resistance
  • Expression regulation
  • Metastasis
  • Prognosis
  • Tumorigenesis

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Li, Z., Liu, J. Y., & Zhang, J-T. (2009). 14-3-3σ, the double-edged sword of human cancers. American Journal of Translational Research, 1(4), 326-340.

14-3-3σ, the double-edged sword of human cancers. / Li, Zhaomin; Liu, Jing Yuan; Zhang, Jian-Ting.

In: American Journal of Translational Research, Vol. 1, No. 4, 2009, p. 326-340.

Research output: Contribution to journalArticle

Li, Z, Liu, JY & Zhang, J-T 2009, '14-3-3σ, the double-edged sword of human cancers', American Journal of Translational Research, vol. 1, no. 4, pp. 326-340.
Li, Zhaomin ; Liu, Jing Yuan ; Zhang, Jian-Ting. / 14-3-3σ, the double-edged sword of human cancers. In: American Journal of Translational Research. 2009 ; Vol. 1, No. 4. pp. 326-340.
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