[18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia

W. K. Davis, Orest Boyko, J. M. Hoffman, M. W. Hanson, S. C. Schold, P. C. Burger, A. H. Friedman, R. E. Coleman

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To correlate the findings of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)enhanced MR imaging with positron emission tomography (PET) in the evaluation of central nervous system neoplasia. MATERIALS AND METHODS: Thirty-six lesions identified on noncontrast MR in 35 patients with biopsy-proved intracranial tumors were imaged with both T1-weighted Cd-DTPA MR at 1.5 T and [18F]2-fiuoro-2-deoxyglucose (FDG) positron emission tomography (PET). Eighteen women and 17 men with a mean age of 47.1 years (range 22-72) were studied. The degrees of Gd-DTPA enhancement and FDG uptake were rated separately, and then all scans were reviewed together. FDG uptake was graded 1-5. RESULTS: Of the 35 lesions rated, 30 had Gd-DTPA enhancement and 28 of these were hypermetabolic (FDG accumulation greater than white matter) on PET (93% concordance). Twenty-six of 32 neoplastic lesions had Gd-DTPA enhancement. Twenty-four of these enhancing tumors were hypermetabolic. Only one lesion was completely missed on PET but identified on routine spin echo MR. CONCLUSION: Gd-DTPA MR and FDG-PET are complementary and there is a high concordance of Gd-DTPA-enhancing tumors displaying FDG hypermetabolism. Although FDG hypermetabolism and Gd-DTPA enhancement are usually suggestive of high-grade malignancy, anaplastic astrocytomas may not enhance with Gd-DTPA and can be hypometabolic. In addition, benign intracranial tumors (two cases of meningioma) and radiation necrosis can be associated with both FDG uptake and Gd-DTPA enhancement.

Original languageEnglish (US)
Pages (from-to)515-527
Number of pages13
JournalAmerican Journal of Neuroradiology
Volume14
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Gadolinium
Deoxyglucose
Positron-Emission Tomography
Central Nervous System
Acids
Neoplasms
Pentetic Acid
Astrocytoma
Meningioma
Necrosis
Radiation
Biopsy

Keywords

  • Brain neoplasms
  • Comparative studies
  • Magnetic resonance
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Davis, W. K., Boyko, O., Hoffman, J. M., Hanson, M. W., Schold, S. C., Burger, P. C., ... Coleman, R. E. (1993). [18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia. American Journal of Neuroradiology, 14(3), 515-527.

[18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia. / Davis, W. K.; Boyko, Orest; Hoffman, J. M.; Hanson, M. W.; Schold, S. C.; Burger, P. C.; Friedman, A. H.; Coleman, R. E.

In: American Journal of Neuroradiology, Vol. 14, No. 3, 1993, p. 515-527.

Research output: Contribution to journalArticle

Davis, WK, Boyko, O, Hoffman, JM, Hanson, MW, Schold, SC, Burger, PC, Friedman, AH & Coleman, RE 1993, '[18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia', American Journal of Neuroradiology, vol. 14, no. 3, pp. 515-527.
Davis, W. K. ; Boyko, Orest ; Hoffman, J. M. ; Hanson, M. W. ; Schold, S. C. ; Burger, P. C. ; Friedman, A. H. ; Coleman, R. E. / [18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia. In: American Journal of Neuroradiology. 1993 ; Vol. 14, No. 3. pp. 515-527.
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abstract = "PURPOSE: To correlate the findings of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)enhanced MR imaging with positron emission tomography (PET) in the evaluation of central nervous system neoplasia. MATERIALS AND METHODS: Thirty-six lesions identified on noncontrast MR in 35 patients with biopsy-proved intracranial tumors were imaged with both T1-weighted Cd-DTPA MR at 1.5 T and [18F]2-fiuoro-2-deoxyglucose (FDG) positron emission tomography (PET). Eighteen women and 17 men with a mean age of 47.1 years (range 22-72) were studied. The degrees of Gd-DTPA enhancement and FDG uptake were rated separately, and then all scans were reviewed together. FDG uptake was graded 1-5. RESULTS: Of the 35 lesions rated, 30 had Gd-DTPA enhancement and 28 of these were hypermetabolic (FDG accumulation greater than white matter) on PET (93{\%} concordance). Twenty-six of 32 neoplastic lesions had Gd-DTPA enhancement. Twenty-four of these enhancing tumors were hypermetabolic. Only one lesion was completely missed on PET but identified on routine spin echo MR. CONCLUSION: Gd-DTPA MR and FDG-PET are complementary and there is a high concordance of Gd-DTPA-enhancing tumors displaying FDG hypermetabolism. Although FDG hypermetabolism and Gd-DTPA enhancement are usually suggestive of high-grade malignancy, anaplastic astrocytomas may not enhance with Gd-DTPA and can be hypometabolic. In addition, benign intracranial tumors (two cases of meningioma) and radiation necrosis can be associated with both FDG uptake and Gd-DTPA enhancement.",
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AU - Davis, W. K.

AU - Boyko, Orest

AU - Hoffman, J. M.

AU - Hanson, M. W.

AU - Schold, S. C.

AU - Burger, P. C.

AU - Friedman, A. H.

AU - Coleman, R. E.

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N2 - PURPOSE: To correlate the findings of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)enhanced MR imaging with positron emission tomography (PET) in the evaluation of central nervous system neoplasia. MATERIALS AND METHODS: Thirty-six lesions identified on noncontrast MR in 35 patients with biopsy-proved intracranial tumors were imaged with both T1-weighted Cd-DTPA MR at 1.5 T and [18F]2-fiuoro-2-deoxyglucose (FDG) positron emission tomography (PET). Eighteen women and 17 men with a mean age of 47.1 years (range 22-72) were studied. The degrees of Gd-DTPA enhancement and FDG uptake were rated separately, and then all scans were reviewed together. FDG uptake was graded 1-5. RESULTS: Of the 35 lesions rated, 30 had Gd-DTPA enhancement and 28 of these were hypermetabolic (FDG accumulation greater than white matter) on PET (93% concordance). Twenty-six of 32 neoplastic lesions had Gd-DTPA enhancement. Twenty-four of these enhancing tumors were hypermetabolic. Only one lesion was completely missed on PET but identified on routine spin echo MR. CONCLUSION: Gd-DTPA MR and FDG-PET are complementary and there is a high concordance of Gd-DTPA-enhancing tumors displaying FDG hypermetabolism. Although FDG hypermetabolism and Gd-DTPA enhancement are usually suggestive of high-grade malignancy, anaplastic astrocytomas may not enhance with Gd-DTPA and can be hypometabolic. In addition, benign intracranial tumors (two cases of meningioma) and radiation necrosis can be associated with both FDG uptake and Gd-DTPA enhancement.

AB - PURPOSE: To correlate the findings of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)enhanced MR imaging with positron emission tomography (PET) in the evaluation of central nervous system neoplasia. MATERIALS AND METHODS: Thirty-six lesions identified on noncontrast MR in 35 patients with biopsy-proved intracranial tumors were imaged with both T1-weighted Cd-DTPA MR at 1.5 T and [18F]2-fiuoro-2-deoxyglucose (FDG) positron emission tomography (PET). Eighteen women and 17 men with a mean age of 47.1 years (range 22-72) were studied. The degrees of Gd-DTPA enhancement and FDG uptake were rated separately, and then all scans were reviewed together. FDG uptake was graded 1-5. RESULTS: Of the 35 lesions rated, 30 had Gd-DTPA enhancement and 28 of these were hypermetabolic (FDG accumulation greater than white matter) on PET (93% concordance). Twenty-six of 32 neoplastic lesions had Gd-DTPA enhancement. Twenty-four of these enhancing tumors were hypermetabolic. Only one lesion was completely missed on PET but identified on routine spin echo MR. CONCLUSION: Gd-DTPA MR and FDG-PET are complementary and there is a high concordance of Gd-DTPA-enhancing tumors displaying FDG hypermetabolism. Although FDG hypermetabolism and Gd-DTPA enhancement are usually suggestive of high-grade malignancy, anaplastic astrocytomas may not enhance with Gd-DTPA and can be hypometabolic. In addition, benign intracranial tumors (two cases of meningioma) and radiation necrosis can be associated with both FDG uptake and Gd-DTPA enhancement.

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