192 IgG-saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN

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Abstract

The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG- saporin immunotoxin on p75NTR and VIP immunoreactivity in the rat SCN. The 192 IgG-saporin immunotoxin abolished p75NTR immunoreactivity in the SCN. VIP immunoreactivity in the SCN of saporin-lesioned animals was not significantly different from that of control animals. Immunolesions of the p75NTR-ir cell population in the SCN may prove useful in clarifying the role of p75NTR in circadian timing.

Original languageEnglish (US)
Pages (from-to)3197-3200
Number of pages4
JournalNeuroReport
Volume9
Issue number14
DOIs
StatePublished - Oct 5 1998

Keywords

  • Circadian rhythm
  • Hypothalamus
  • Immunolesion
  • Immunotoxin
  • Low-affinity nerve growth factor receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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