1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy

J. Suhy, K. D. Laxer, A. A. Capizzano, P. Vermathen, G. B. Matson, Nicholas Barbaro, M. W. Weiner

Research output: Contribution to journalArticle

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Abstract

1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non-seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsilateral z scores were lower than the seizure-free patients' (SF) ipsilateral z scores (p = 0.0049). Similarly, NSF contralateral scores were lower than contralateral SF (p = 0.02). These findings suggest NAA predicts the surgical outcome in patients with TLE without evidence of mesial temporal sclerosis on MRI.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalNeurology
Volume58
Issue number5
StatePublished - Mar 12 2002
Externally publishedYes

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Temporal Lobe Epilepsy
Seizures
Sclerosis
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Suhy, J., Laxer, K. D., Capizzano, A. A., Vermathen, P., Matson, G. B., Barbaro, N., & Weiner, M. W. (2002). 1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy. Neurology, 58(5), 821-823.

1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy. / Suhy, J.; Laxer, K. D.; Capizzano, A. A.; Vermathen, P.; Matson, G. B.; Barbaro, Nicholas; Weiner, M. W.

In: Neurology, Vol. 58, No. 5, 12.03.2002, p. 821-823.

Research output: Contribution to journalArticle

Suhy, J, Laxer, KD, Capizzano, AA, Vermathen, P, Matson, GB, Barbaro, N & Weiner, MW 2002, '1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy', Neurology, vol. 58, no. 5, pp. 821-823.
Suhy J, Laxer KD, Capizzano AA, Vermathen P, Matson GB, Barbaro N et al. 1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy. Neurology. 2002 Mar 12;58(5):821-823.
Suhy, J. ; Laxer, K. D. ; Capizzano, A. A. ; Vermathen, P. ; Matson, G. B. ; Barbaro, Nicholas ; Weiner, M. W. / 1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy. In: Neurology. 2002 ; Vol. 58, No. 5. pp. 821-823.
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AU - Matson, G. B.

AU - Barbaro, Nicholas

AU - Weiner, M. W.

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