5-HT 2 receptor distribution shown by [ 18F] setoperone PET in high-functioning autistic adults

David Q. Beversdorf, Richard E. Nordgren, Ali A. Bonab, Alan J. Fischman, Steven B. Weise, Darin D. Dougherty, Gretchen J. Felopulos, Feng Zhou, Margaret L. Bauman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The serotonergic system is implicated in disordered emotional behavior. Autism is characterized by impaired processing of emotional information. The serotonergic (5-HT) system is also critically involved in brain development, and abnormal brain synthesis of serotonin is observed in autism. Furthermore, whole blood and platelet serotonin have been reported to be elevated in autism. The authors examined the CNS serotonin system in autism in vivo. 5-HT 2 receptors were visualized by PET imaging of [ 18F]setoperone-binding in this pilot study of 6 high-functioning autistic adults and 10 matched-control participants. Autism subjects had less thalamic [ 18F]setoperone binding than controls, when covaried for age, but no difference reached significance in other areas. A negative relationship between thalamic binding and history of language impairment was also observed. Further studies will be needed to gain a clearer picture of the role of the 5-HT system in autism.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume24
Issue number2
StatePublished - Jul 2012

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Serotonin 5-HT2 Receptors
Autistic Disorder
Serotonin
Brain
Automatic Data Processing
setoperone
Language
Blood Platelets

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology
  • Medicine(all)

Cite this

Beversdorf, D. Q., Nordgren, R. E., Bonab, A. A., Fischman, A. J., Weise, S. B., Dougherty, D. D., ... Bauman, M. L. (2012). 5-HT 2 receptor distribution shown by [ 18F] setoperone PET in high-functioning autistic adults. Journal of Neuropsychiatry and Clinical Neurosciences, 24(2), 191-197.

5-HT 2 receptor distribution shown by [ 18F] setoperone PET in high-functioning autistic adults. / Beversdorf, David Q.; Nordgren, Richard E.; Bonab, Ali A.; Fischman, Alan J.; Weise, Steven B.; Dougherty, Darin D.; Felopulos, Gretchen J.; Zhou, Feng; Bauman, Margaret L.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 24, No. 2, 07.2012, p. 191-197.

Research output: Contribution to journalArticle

Beversdorf, DQ, Nordgren, RE, Bonab, AA, Fischman, AJ, Weise, SB, Dougherty, DD, Felopulos, GJ, Zhou, F & Bauman, ML 2012, '5-HT 2 receptor distribution shown by [ 18F] setoperone PET in high-functioning autistic adults', Journal of Neuropsychiatry and Clinical Neurosciences, vol. 24, no. 2, pp. 191-197.
Beversdorf DQ, Nordgren RE, Bonab AA, Fischman AJ, Weise SB, Dougherty DD et al. 5-HT 2 receptor distribution shown by [ 18F] setoperone PET in high-functioning autistic adults. Journal of Neuropsychiatry and Clinical Neurosciences. 2012 Jul;24(2):191-197.
Beversdorf, David Q. ; Nordgren, Richard E. ; Bonab, Ali A. ; Fischman, Alan J. ; Weise, Steven B. ; Dougherty, Darin D. ; Felopulos, Gretchen J. ; Zhou, Feng ; Bauman, Margaret L. / 5-HT 2 receptor distribution shown by [ 18F] setoperone PET in high-functioning autistic adults. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2012 ; Vol. 24, No. 2. pp. 191-197.
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