5-HT2 receptor distribution shown by [18F] setoperone PET in high-functioning autistic adults

David Q. Beversdorf, Richard E. Nordgren, Ali A. Bonab, Alan J. Fischman, Steven B. Weise, Darin D. Dougherty, Gretchen J. Felopulos, Feng C. Zhou, Margaret L. Bauman

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The serotonergic system is implicated in disordered emotional behavior. Autism is characterized by impaired processing of emotional information. The serotonergic (5-HT) system is also critically involved in brain development, and abnormal brain synthesis of serotonin is observed in autism. Furthermore, whole blood and platelet serotonin have been reported to be elevated in autism. The authors examined the CNS serotonin system in autism in vivo. 5-HT 2 receptors were visualized by PET imaging of [ 18F]setoperone-binding in this pilot study of 6 high-functioning autistic adults and 10 matched-control participants. Autism subjects had less thalamic [ 18F]setoperone binding than controls, when covaried for age, but no difference reached significance in other areas. A negative relationship between thalamic binding and history of language impairment was also observed. Further studies will be needed to gain a clearer picture of the role of the 5-HT system in autism.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume24
Issue number2
DOIs
StatePublished - Jul 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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    Beversdorf, D. Q., Nordgren, R. E., Bonab, A. A., Fischman, A. J., Weise, S. B., Dougherty, D. D., Felopulos, G. J., Zhou, F. C., & Bauman, M. L. (2012). 5-HT2 receptor distribution shown by [18F] setoperone PET in high-functioning autistic adults. Journal of Neuropsychiatry and Clinical Neurosciences, 24(2), 191-197. https://doi.org/10.1176/appi.neuropsych.11080202