670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo

Ronnie L. Yeager, Jinhwan Lim, Deborah S. Millsap, Ashley V. Jasevicius, Ruth A. Sanders, Harry T. Whelan, John B. Watkins, Janis T. Eells, Diane S. Henshel

Research output: Contribution to journalArticle

  • 14 Citations

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an acutely toxic anthropogenic chemical. Treatment with a red to near-infrared (630-1000 nm) light-emitting diode (LED) attenuates the toxicant-induced oxidative stress and energy deficit in neuronal cell culture. For this study, fertile chicken (Gallus gallus) eggs were injected once at the start of incubation with sunflower oil vehicle or 200 pg TCDD/g egg (200 parts per trillion), an environmentally relevant dose. Daily LED treatment after TCDD exposure reduced embryonic mortality by 47%. LED treatment of TCDD-exposed eggs also decreased the hepatic oxidized-to-reduced glutathione ratio by 88%. Activities of other hepatic indicators of oxidative stress, such as glutathione reductase and catalase, were increased after LED treatment of TCDD-exposed eggs. Our study demonstrates that 670 nm phototherapy can mitigate the oxidative stress and energy deficit resulting from developmental exposure to TCDD while reducing TCDD-induced embryo mortality. Moreover, LED treatment restores hepatic enzyme activities to control levels in TCDD-exposed embryos. The effective attenuation of TCDD-induced embryo toxicity by LED treatment could extend to mitigating the effects of other teratogens that induce oxidative and energy stress.

LanguageEnglish
Pages271-278
Number of pages8
JournalJournal of Biochemical and Molecular Toxicology
Volume20
Issue number6
DOIs
StatePublished - 2006

Fingerprint

Dioxins
Chick Embryo
Toxicity
Light
Light emitting diodes
Oxidative stress
Oxidative Stress
Eggs
Therapeutics
Embryonic Structures
Chickens
Liver
Teratogens
Polychlorinated Dibenzodioxins
1,4-dioxin
Phototherapy
Mortality
Glutathione Reductase
Poisons
Level control

Keywords

  • Antioxidants
  • Chick
  • Dioxin
  • Embryo
  • Glutathione

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Yeager, R. L., Lim, J., Millsap, D. S., Jasevicius, A. V., Sanders, R. A., Whelan, H. T., ... Henshel, D. S. (2006). 670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo. Journal of Biochemical and Molecular Toxicology, 20(6), 271-278. https://doi.org/10.1002/jbt.20146

670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo. / Yeager, Ronnie L.; Lim, Jinhwan; Millsap, Deborah S.; Jasevicius, Ashley V.; Sanders, Ruth A.; Whelan, Harry T.; Watkins, John B.; Eells, Janis T.; Henshel, Diane S.

In: Journal of Biochemical and Molecular Toxicology, Vol. 20, No. 6, 2006, p. 271-278.

Research output: Contribution to journalArticle

Yeager, RL, Lim, J, Millsap, DS, Jasevicius, AV, Sanders, RA, Whelan, HT, Watkins, JB, Eells, JT & Henshel, DS 2006, '670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo' Journal of Biochemical and Molecular Toxicology, vol. 20, no. 6, pp. 271-278. https://doi.org/10.1002/jbt.20146
Yeager, Ronnie L. ; Lim, Jinhwan ; Millsap, Deborah S. ; Jasevicius, Ashley V. ; Sanders, Ruth A. ; Whelan, Harry T. ; Watkins, John B. ; Eells, Janis T. ; Henshel, Diane S. / 670 Nanometer light treatment attenuates dioxin toxicity in the developing chick embryo. In: Journal of Biochemical and Molecular Toxicology. 2006 ; Vol. 20, No. 6. pp. 271-278.
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