67Ga citrate distribution following whole body irradiation or chemotherapy

James Fletcher, F. K. Herbig, R. M. Donati

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Whole body retention, organ distribution, excretion, and serum binding of 67Ga were evaluated in rats under normal conditions and following whole body gamma irradiation, vincristine sulfate, or mechlorethamine. The results suggest that both irradiation and chemotherapy lead to reduced whole body retention of injected radiogallium, explained in part by an alteration in the serum binding of gallium. Recognition of these findings should be considered in interpreting decreased tumor concentration of gallium in patients following radiotherapy or chemotherapy.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalRadiology
Volume117
Issue number3 I
StatePublished - 1975
Externally publishedYes

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Gallium
Whole-Body Irradiation
Citric Acid
Drug Therapy
Mechlorethamine
Vincristine
Serum
Radiotherapy
Neoplasms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Fletcher, J., Herbig, F. K., & Donati, R. M. (1975). 67Ga citrate distribution following whole body irradiation or chemotherapy. Radiology, 117(3 I), 709-712.

67Ga citrate distribution following whole body irradiation or chemotherapy. / Fletcher, James; Herbig, F. K.; Donati, R. M.

In: Radiology, Vol. 117, No. 3 I, 1975, p. 709-712.

Research output: Contribution to journalArticle

Fletcher, J, Herbig, FK & Donati, RM 1975, '67Ga citrate distribution following whole body irradiation or chemotherapy', Radiology, vol. 117, no. 3 I, pp. 709-712.
Fletcher, James ; Herbig, F. K. ; Donati, R. M. / 67Ga citrate distribution following whole body irradiation or chemotherapy. In: Radiology. 1975 ; Vol. 117, No. 3 I. pp. 709-712.
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