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  • Lynda Bonewald
2013

Potential toxicity of bioactive borate glasses in-vitro and in-vivo

Jung, S. B., Day, D. E., Brown, R. F. & Bonewald, L. F., Apr 8 2013, Advances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012. 6 ed. p. 65-74 10 p. (Ceramic Engineering and Science Proceedings; vol. 33, no. 6).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations
2019

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice

Essex, A. L., Pin, F., Huot, J. R., Bonewald, L. F., Plotkin, L. I. & Bonetto, A., Nov 19 2019, In : Frontiers in Endocrinology. 10, 809.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2012

DNA methylation contributes to the regulation of sclerostin expression in human osteocytes

Delgado-Calle, J., Sañudo, C., Bolado, A., Fernández, A. F., Arozamena, J., Pascual-Carra, M. A., Rodriguez-Rey, J. C., Fraga, M. F., Bonewald, L. & Riancho, J. A., Apr 1 2012, In : Journal of Bone and Mineral Research. 27, 4, p. 926-937 12 p.

Research output: Contribution to journalArticle

78 Scopus citations
2014

Healing of critical-size segmental defects in rat femora using strong porous bioactive glass scaffolds

Bi, L., Zobell, B., Liu, X., Rahaman, M. N. & Bonewald, L. F., Sep 1 2014, In : Materials Science and Engineering C. 42, p. 816-824 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Osteocyte Biology

Bonewald, L. F., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 209-234 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

FGF23 production by osteocytes

Bonewald, L. F. & Wacker, M. J., Apr 1 2013, In : Pediatric Nephrology. 28, 4, p. 563-568 6 p.

Research output: Contribution to journalReview article

55 Scopus citations

Preface: The Osteocyte

Bonewald, L. F., Kneissel, M. & Johnson, M., Jun 1 2013, In : Bone. 54, 2, 1 p.

Research output: Contribution to journalEditorial

15 Scopus citations

The osteocyte: An endocrine cell . . . and more

Dallas, S. L., Prideaux, M. & Bonewald, L. F., Oct 29 2013, In : Endocrine Reviews. 34, 5, p. 658-690 33 p.

Research output: Contribution to journalReview article

424 Scopus citations
2014

Investigation of nutrient transport mechanisms in the lacunae-canaliculi system

Scheiner, S., Théoval, A., Pivonka, P., Smith, D. W. & Bonewald, L. F., Jan 1 2014, In : IOP Conference Series: Materials Science and Engineering. 10, 1, 012129.

Research output: Contribution to journalConference article

2015

Connexin 43 channels are essential for normal bone structure and osteocyte viability

Xu, H., Gu, S., Riquelme, M. A., Burra, S., Callaway, D., Cheng, H., Guda, T., Schmitz, J., Fajardo, R. J., Werner, S. L., Zhao, H., Shang, P., Johnson, M. L., Bonewald, L. F. & Jiang, J. X., Mar 1 2015, In : Journal of Bone and Mineral Research. 30, 3, p. 550-562 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2011

The holy grail of high bone mass

Bonewald, L., Jun 1 2011, In : Nature Medicine. 17, 6, p. 657-658 2 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Enhanced bone regeneration in rat calvarial defects implanted with surface-modified and BMP-loaded bioactive glass (13-93) scaffolds

Liu, X., Rahaman, M. N., Liu, Y., Bal, B. S. & Bonewald, L. F., Jul 1 2013, In : Acta Biomaterialia. 9, 7, p. 7506-7517 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2019

Erratum: Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (Cell (2018) 175(7) (1756–1768.e17), (S0092867418313345), (10.1016/j.cell.2018.10.025))

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V. J. A., Novick, S. J., Strutzenberg, T. S., Pascal, B. D., Le, P. T., Brooks, D. J., Roche, A. M., Gerber, K. K., Mattheis, L., Chen, W., Tu, H., Bouxsein, M. L. & 5 others, Griffin, P. R., Baron, R., Rosen, C. J., Bonewald, L. F. & Spiegelman, B. M., Jul 11 2019, In : Cell. 178, 2, p. 507-508 2 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations
2018

Osteocyte Biology

Bellido, T., Pajevic, P. D. & Bonewald, L., Jan 1 2018, Genetics of Bone Biology and Skeletal Disease: Second Edition. Elsevier Inc., p. 227-240 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Osteoblast/ osteocyte interactions

Bonewald, L., Jul 2012, In : European Cells and Materials. 24, SUPPL. 1, 1 p.

Research output: Contribution to journalComment/debate

2018

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression

Colditz, J., Thiele, S., Baschant, U., Niehrs, C., Bonewald, L. F., Hofbauer, L. C. & Rauner, M., Sep 2018, In : Journal of Bone and Mineral Research. 33, 9, p. 1698-1707 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Silorane resin supports proliferation, differentiation, and mineralization of MLO-A5 bone cells in vitro and bone formation in vivo

Eick, J. D., Barragan-Adjemian, C., Rosser, J., Melander, J. R., Dusevich, V., Weiler, R. A., Miller, B. D., Kilway, K. V., Dallas, M. R., Bi, L., Nalvarte, E. L. & Bonewald, L. F., Apr 1 2012, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 100 B, 3, p. 850-861 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical-sized rat calvarial defects implanted with bioactive glass scaffolds

Bi, L., Jung, S., Day, D., Neidig, K., Dusevich, V., Eick, D. & Bonewald, L., Dec 2012, In : Journal of Biomedical Materials Research - Part A. 100 A, 12, p. 3267-3275 9 p.

Research output: Contribution to journalArticle

71 Scopus citations
2017

Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers

Vemula, H., Kitase, Y., Ayon, N. J., Bonewald, L. & Gutheil, W. G., Jan 1 2017, In : Analytical biochemistry. 516, p. 75-85 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Bone and muscle: Interactions beyond mechanical

Brotto, M. & Bonewald, L., Nov 1 2015, In : Bone. 80, p. 109-114 6 p.

Research output: Contribution to journalReview article

94 Scopus citations
2017

Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo

Jähn, K., Kelkar, S., Zhao, H., Xie, Y., Tiede-Lewis, L. A. M., Dusevich, V., Dallas, S. L. & Bonewald, L., Aug 1 2017, In : Journal of Bone and Mineral Research. 32, 8, p. 1761-1772 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

Prostaglandin E2: From clinical applications to its potential role in bone-muscle crosstalk and myogenic differentiation

Mo, C., Romero-Suarez, S., Bonewald, L., Johnson, M. & Brotto, M., Dec 1 2012, In : Recent Patents on Biotechnology. 6, 3, p. 223-229 7 p.

Research output: Contribution to journalArticle

67 Scopus citations
2018

β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M. & Bonewald, L., Feb 6 2018, In : Cell Reports. 22, 6, p. 1531-1544 14 p.

Research output: Contribution to journalArticle

42 Scopus citations
2019

Characterization of a novel murine Sost ER T2 Cre model targeting osteocytes

Maurel, D. B., Matsumoto, T., Vallejo, J. A., Johnson, M. L., Dallas, S. L., Kitase, Y., Brotto, M., Wacker, M. J., Harris, M. A., Harris, S. E. & Bonewald, L. F., Dec 1 2019, In : Bone Research. 7, 1, 6.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2014

METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway

Huang, J., Hsu, Y. H., Mo, C., Abreu, E., Kiel, D. P., Bonewald, L. F., Brotto, M. & Karasik, D., Jul 2014, In : Journal of Bone and Mineral Research. 29, 7, p. 1531-1540 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels

Batra, N., Burra, S., Siller-Jackson, A. J., Gu, S., Xia, X., Weber, G. F., DeSimone, D., Bonewald, L. F., Lafer, E. M., Sprague, E., Schwartz, M. A. & Jiang, J. X., Feb 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3359-3364 6 p.

Research output: Contribution to journalArticle

129 Scopus citations
2014

Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice

Kondoh, S., Inoue, K., Igarashi, K., Sugizaki, H., Shirode-Fukuda, Y., Inoue, E., Yu, T., Takeuchi, J. K., Kanno, J., Bonewald, L. F. & Imai, Y., Mar 1 2014, In : Bone. 60, p. 68-77 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin

Jähn, K., Lara-Castillo, N., Brotto, L., Mo, C. L., Johnson, M. L., Brotto, M. & Bonewald, L. F., 2012, In : European Cells and Materials. 24, p. 197-210 14 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations
2018

Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia

Pin, F., Barreto, R., Kitase, Y., Mitra, S., Erne, C. E., Novinger, L. J., Zimmers, T. A., Couch, M. E., Bonewald, L. F. & Bonetto, A., Aug 2018, In : Journal of Cachexia, Sarcopenia and Muscle. 9, 4, p. 685-700 16 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012

Bioactive glass in bone tissue engineering

Rahaman, M. N., Liu, X., Bal, B. S., Day, D. E., Bi, L. & Bonewald, L. F., Jan 1 2012, Biomaterials Science: Processing, Properties and Applications II. American Ceramic Society, p. 73-82 10 p. (Ceramic Transactions; vol. 237).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations
2019

A Novel Osteogenic Cell Line That Differentiates Into GFP-Tagged Osteocytes and Forms Mineral With a Bone-Like Lacunocanalicular Structure

Wang, K., Le, L., Chun, B. M., Tiede-Lewis, L. A. M., Shiflett, L. A., Prideaux, M., Campos, R. S., Veno, P. A., Xie, Y., Dusevich, V., Bonewald, L. F. & Dallas, S. L., Jun 2019, In : Journal of Bone and Mineral Research. 34, 6, p. 979-995 17 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Preliminary evidence of early bone resorption in a sheep model of acute burn injury: An observational study

Klein, G. L., Xie, Y., Qin, Y. X., Lin, L., Hu, M., Enkhbaatar, P. & Bonewald, L. F., 2014, In : Journal of Bone and Mineral Metabolism. 32, 2, p. 136-141 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling

Fulzele, K., Krause, D. S., Panaroni, C., Saini, V., Barry, K. J., Liu, X., Lotinun, S., Baron, R., Bonewald, L., Feng, J. Q., Chen, M., Weinstein, L. S., Wu, J. Y., Kronenberg, H. M., Scadden, D. T. & Pajevic, P. D., Feb 7 2013, In : Blood. 121, 6, p. 930-939 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

President's Preface

Bonewald, L., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. xxv

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

2019

Use it or lose it to age: A review of bone and muscle communication

Bonewald, L., Mar 2019, In : Bone. 120, p. 212-218 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age

Jilka, R. L., O'Brien, C. A., Roberson, P. K., Bonewald, L. F., Weinstein, R. S. & Manolagas, S. C., Jan 1 2014, In : Journal of Bone and Mineral Research. 29, 1, p. 103-117 15 p.

Research output: Contribution to journalArticle

42 Scopus citations
2015

Osteocytes, not osteoblasts or lining cells, are the main source of the RANKL required for osteoclast formation in remodeling bone

Xiong, J., Piemontese, M., Onal, M., Campbell, J., Goellner, J. J., Dusevich, V., Bonewald, L., Manolagas, S. C. & O'Brien, C. A., Sep 22 2015, In : PLoS ONE. 10, 9, e0138189.

Research output: Contribution to journalArticle

107 Scopus citations
2016

Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition

Yamamoto, H., Ramos-Molina, B., Lick, A. N., Prideaux, M., Albornoz, V., Bonewald, L. & Lindberg, I., Mar 1 2016, In : Bone. 84, p. 120-130 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2

Kogawa, M., Wijenayaka, A. R., Ormsby, R. T., Thomas, G. P., Anderson, P. H., Bonewald, L. F., Findlay, D. M. & Atkins, G. J., Dec 1 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2436-2448 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells

Ito, N., Findlay, D. M., Anderson, P. H., Bonewald, L. F. & Atkins, G. J., Jan 1 2013, In : Journal of Steroid Biochemistry and Molecular Biology. 136, 1, p. 183-186 4 p.

Research output: Contribution to journalReview article

35 Scopus citations
2019

Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients

Pin, F., Bonetto, A., Bonewald, L. F. & Klein, G. L., Aug 7 2019, In : Frontiers in Endocrinology. 10, 543.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2013

Osteocytes

Bonewald, L., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 34-41 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations
2015

Parathyroid hormone induces bone cell motility and loss of mature osteocyte phenotype through L-calcium channel dependent and independent mechanisms

Prideaux, M., Dallas, S. L., Zhao, N., Johnsrud, E. D., Veno, P. A., Guo, D., Mishina, Y., Harris, S. E. & Bonewald, L. F., May 5 2015, In : PloS one. 10, 5, e0125731.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Potential of bioact1ve glass scaffolds as implants for structural bone repair

Rahaman, M. N., Bal, B. S. & Bonewald, L., 2016, Advances in Bioceramics and Porous Ceramics VIII - A Collection of Papers Presented at the 39th International Conference on Advanced Ceramics and Composites. 5 ed. American Ceramic Society, Vol. 36. p. 3-15 13 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
2015

Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli

Ito, N., Wijenayaka, A. R., Prideaux, M., Kogawa, M., Ormsby, R. T., Evdokiou, A., Bonewald, L. F., Findlay, D. M. & Atkins, G. J., Jan 5 2015, In : Molecular and Cellular Endocrinology. 399, p. 208-218 11 p.

Research output: Contribution to journalArticle

76 Scopus citations
2013

Cell Biology of Craniofacial Bone: Osteocytes

Bonewald, L. F., Apr 5 2013, Mineralized Tissues in Oral and Craniofacial Science: Biological Principles and Clinical Correlates. John Wiley and Sons, p. 63-70 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Osteocyte mechanosensation and transduction

Bonewald, L. F., Jan 1 2011, Mechanosensing Biology. Springer Japan, Vol. 9784431897576. p. 141-155 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2012

Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice

Stern, A. R., Stern, M. M., van Dyke, M. E., Jähn, K., Prideaux, M. & Bonewald, L. F., Jun 1 2012, In : BioTechniques. 52, 6, p. 361-373 13 p.

Research output: Contribution to journalArticle

107 Scopus citations
2017

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Medina-Gomez, C., Kemp, J. P., Dimou, N. L., Kreiner, E., Chesi, A., Zemel, B. S., Bønnelykke, K., Boer, C. G., Ahluwalia, T. S., Bisgaard, H., Evangelou, E., Heppe, D. H. M., Bonewald, L. F., Gorski, J. P., Ghanbari, M., Demissie, S., Duque, G., Maurano, M. T., Kiel, D. P., Hsu, Y. H. & 14 others, Van Der Eerden, B. C. J., Ackert-Bicknell, C., Reppe, S., Gautvik, K. M., Raastad, T., Karasik, D., Van De Peppel, J., Jaddoe, V. W. V., Uitterlinden, A. G., Tobias, J. H., Grant, S. F. A., Bagos, P. G., Evans, D. M. & Rivadeneira, F., Dec 1 2017, In : Nature communications. 8, 1, 121.

Research output: Contribution to journalArticle

28 Scopus citations
2013

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity

William Lau, K. H., Baylink, D. J., Zhou, X. D., Rodriguez, D., Bonewald, L. F., Li, Z., Ruffoni, D., Müller, R., Kesavan, C. & Sheng, M. H. C., Jul 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 2, p. E271-E281

Research output: Contribution to journalArticle

53 Scopus citations