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  • Zhong-Yin Zhang
2013

Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis

He, R., Zeng, L. F., He, Y., Wu, L., Gunawan, A. M. & Zhang, Z. Y., Feb 12 2013, In : Chemical Communications. 49, 20, p. 2064-2066 3 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Phosphatase of regenerating liver: A novel target for cancer therapy

Campbell, A. M. & Zhang, Z. Y., May 2014, In : Expert Opinion on Therapeutic Targets. 18, 5, p. 555-569 15 p.

Research output: Contribution to journalReview article

26 Scopus citations
2016

Current status of PTP-based therapeutics

He, R. & Zhang, Z-Y., Jan 1 2016, Protein Tyrosine Phosphatases in Cancer. Springer New York, p. 335-353 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta

Zeng, L. F., Zhang, R. Y., Bai, Y., Wu, L., Gunawan, A. M. & Zhang, Z. Y., May 10 2014, In : Antioxidants and Redox Signaling. 20, 14, p. 2130-2140 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases

Piovan, L., Wu, L., Zhang, Z. Y. & Andrade, L. H., Mar 1 2011, In : Organic and Biomolecular Chemistry. 9, 5, p. 1347-1351 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

Chen, X., Wang, H., Liao, H. J., Hu, W., Gewin, L., Mernaugh, G., Zhang, S., Zhang, Z. Y., Vega-Montoto, L., Vanacore, R. M., Fässler, R., Zent, R. & Pozzi, A., Aug 1 2014, In : Journal of Clinical Investigation. 124, 8, p. 3295-3310 16 p.

Research output: Contribution to journalArticle

39 Scopus citations
2012

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Stanford, S. M., Panchal, R. G., Walker, L. M., Wu, D. J., Falk, M. D., Mitra, S., Damle, S. S., Ruble, D., Kaltcheva, T., Zhang, S., Zhang, Z. Y., Bavari, S., Barrios, A. M. & Bottini, N., Aug 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 35, p. 13972-13977 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

IGF-1R modulation of acute GH-induced STAT5 signaling: Role of protein tyrosine phosphatase activity

Gan, Y., Zhang, Y., Buckels, A., Paterson, A. J., Jiang, J., Clemens, T. L., Zhang, Z. Y., Du, K., Chang, Y. & Frank, S. J., 2013, In : Molecular Endocrinology. 27, 11, p. 1969-1979 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors

He, Y., Zeng, L. F., Yu, Z. H., He, R., Liu, S. & Zhang, Z. Y., Mar 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 6, p. 1940-1946 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2015

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Zhang, Z. Y., Dodd, G. T. & Tiganis, T., Oct 1 2015, In : Trends in Pharmacological Sciences. 36, 10, p. 661-674 14 p.

Research output: Contribution to journalReview article

81 Scopus citations
2013

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases

He, Y., Liu, S., Menon, A., Stanford, S., Oppong, E., Gunawan, A. M., Wu, L., Wu, D. J., Barrios, A. M., Bottini, N., Cato, A. C. B. & Zhang, Z. Y., Jun 27 2013, In : Journal of Medicinal Chemistry. 56, 12, p. 4990-5008 19 p.

Research output: Contribution to journalArticle

42 Scopus citations
2019

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z. Y., Gribble, G. W., Spinola, S. M. & Duerfeldt, A. S., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1836-1841 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

Hamerman, J. A., Pottle, J., Ni, M., He, Y., Zhang, Z. Y. & Buckner, J. H., Jan 1 2016, In : Immunological Reviews. 269, 1, p. 212-227 16 p.

Research output: Contribution to journalArticle

51 Scopus citations
2015

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Bunda, S., Burrell, K., Heir, P., Zeng, L., Alamsahebpour, A., Kano, Y., Raught, B., Zhang, Z. Y., Zadeh, G. & Ohh, M., Nov 30 2015, In : Nature communications. 6, 8859.

Research output: Contribution to journalArticle

66 Scopus citations

Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice

Xi, Y., Liu, S., Bettaieb, A., Matsuo, K., Matsuo, I., Hosein, E., Chahed, S., Wiede, F., Zhang, S., Zhang, Z. Y., Kulkarni, R. N., Tiganis, T. & Haj, F. G., Jan 1 2015, In : Diabetologia. 58, 1, p. 122-131 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., Wang, Q., Shen, H., Yao, X., Zhang, Z. Y., Xue, S., Shen, L. & Cheng, J., 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies

Kobayashi, M., Chen, S., Gao, R., Bai, Y., Zhang, Z. Y. & Liu, Y., Jan 1 2014, In : Cell Cycle. 13, 18, p. 2827-2835 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L. F., Zhang, Z. Y., Feng, G. S., Hartmann, K., Roers, A. & Craig, A. W. B., Jul 1 2012, In : Molecular and cellular biology. 32, 14, p. 2653-2663 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis

Bai, Y., Zhou, H. M., Zhang, L., Dong, Y., Zeng, Q., Shou, W. & Zhang, Z. Y., Sep 26 2016, In : Scientific reports. 6, 34211.

Research output: Contribution to journalArticle

8 Scopus citations
2018

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Zehender, A., Huang, J., Györfi, A. H., Matei, A. E., Trinh-Minh, T., Xu, X., Li, Y. N., Chen, C. W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z. Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. & Distler, J. H. W., Dec 1 2018, In : Nature communications. 9, 1, 3259.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-hydroxy-benzofuran-5-carboxylic acid scaffold

He, Y., Xu, J., Yu, Z. H., Gunawan, A. M., Wu, L., Wang, L. & Zhang, Z. Y., Feb 14 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 832-842 11 p.

Research output: Contribution to journalArticle

59 Scopus citations
2018

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z. Y. & Deng, Q., Mar 29 2018, In : Frontiers in immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

6 Scopus citations
2011

SHP2 is a target of the immunosuppressant tautomycetin

Liu, S., Yu, Z., Yu, X., Huang, S. X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R. J., Shen, B. & Zhang, Z. Y., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2014

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D. & Zhang, Z. Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

58 Scopus citations
2018

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z. Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., Sep 2018, In : eLife. 7, e38704.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

He, R., Wang, J., Yu, Z. H., Zhang, R. Y., Liu, D. S., Wu, L. & Zhang, Z. Y., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9094-9106 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

The tumor promoter-activated protein kinase Cs are a system for regulating filopodia

Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z. Y. & Boudreau, N. S., Aug 2017, In : Cytoskeleton. 74, 8, p. 297-314 18 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes

Zhang, S., Liu, S., Tao, R., Wei, D., Chen, L., Shen, W., Yu, Z. H., Wang, L., Jones, D. R., Dong, X. C. & Zhang, Z. Y., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 18116-18124 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction

Yakubov, B., Chen, L., Belkin, A. M., Zhang, S., Chelladurai, B., Zhang, Z. Y. & Matei, D., Feb 20 2014, In : PloS one. 9, 2, e89285.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening

Yu, Z. H., Chen, L., Wu, L., Liu, S., Wang, L. & Zhang, Z. Y., Jul 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 14, p. 4238-4242 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus

Wang, J., Mizui, M., Zeng, L. F., Bronson, R., Finnell, M., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z. Y. & Kontaridis, M. I., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2077-2092 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2017

Therapeutic targeting of oncogenic tyrosine phosphatases

Frankson, R., Yu, Z. H., Bai, Y., Li, Q., Zhang, R. Y. & Zhang, Z. Y., Nov 1 2017, In : Cancer Research. 77, 21, p. 5701-5705 5 p.

Research output: Contribution to journalReview article

36 Scopus citations
2016

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Zhang, R. Y., Yu, Z. H., Zeng, L., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. & Zhang, Z. Y., Jan 1 2016, In : Oncotarget. 7, 45, p. 73817-73829 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores

Martin, V. A., Wang, W. H., Lipchik, A. M., Parker, L. L., He, Y., Zhang, S., Zhang, Z. Y. & Geahlen, R. L., May 1 2012, In : Cellular Signalling. 24, 5, p. 1064-1073 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

Negro, R., Gobessi, S., Longo, P. G., He, Y., Zhang, Z. Y., Laurenti, L. & Efremov, D. G., Jun 28 2012, In : Blood. 119, 26, p. 6278-6287 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
2014

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

Liao, J., Wu, C. X., Burlak, C., Zhang, S., Sahm, H., Wang, M., Zhang, Z. Y., Vogel, K. W., Federici, M., Riddle, S. M., Nichols, R. J., Liu, D., Cookson, M. R., Stone, T. A. & Hoang, Q. Q., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4055-4060 6 p.

Research output: Contribution to journalArticle

69 Scopus citations
2013

Integrated Analysis of Global mRNA and Protein Expression Data in HEK293 Cells Overexpressing PRL-1

Dumaual, C. M., Steere, B. A., Walls, C. D., Wang, M., Zhang, Z. Y. & Randall, S. K., Sep 3 2013, In : PloS one. 8, 9, e72977.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis

He, R., Bai, Y., Yu, Z. H., Wu, L., Gunawan, A. M. & Zhang, Z. Y., Oct 1 2014, In : MedChemComm. 5, 10, p. 1496-1499 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases

Selner, N. G., Luechapanichkul, R., Chen, X., Neel, B. G., Zhang, Z. Y., Knapp, S., Bell, C. E. & Pei, D., Jan 21 2014, In : Biochemistry. 53, 2, p. 397-412 16 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals

Zhu, H. H., Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z., Zhou, Z., Yao, J., Zeng, L., Ji, K., Gao, W. Q., Zhang, Z. Y. & Feng, G. S., Oct 27 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 43, p. 13342-13347 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Protein tyrosine phosphatases as potential therapeutic targets

He, R. J., Yu, Z. H., Zhang, R. Y. & Zhang, Z. Y., Sep 25 2014, In : Development (Basingstoke). 57, 1, p. 1227-1246 20 p.

Research output: Contribution to journalReview article

152 Scopus citations
2011

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

Loh, K., Fukushima, A., Zhang, X., Galic, S., Briggs, D., Enriori, P. J., Simonds, S., Wiede, F., Reichenbach, A., Hauser, C., Sims, N. A., Bence, K. K., Zhang, S., Zhang, Z. Y., Kahn, B. B., Neel, B. G., Andrews, Z. B., Cowley, M. A. & Tiganis, T., Nov 2 2011, In : Cell Metabolism. 14, 5, p. 684-699 16 p.

Research output: Contribution to journalArticle

118 Scopus citations
2012

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

Loh, K., Merry, T. L., Galic, S., Wu, B. J., Watt, M. J., Zhang, S., Zhang, Z. Y., Neel, B. G. & Tiganis, T., Feb 1 2012, In : Diabetologia. 55, 2, p. 468-478 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Sharma, N., Everingham, S., Zeng, L. F., Zhang, Z. Y., Kapur, R. & Craig, A. W. B., 2014, In : Oncotarget. 5, 15, p. 6130-6141 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2013

Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation

Bettaieb, A., Bakke, J., Nagata, N., Matsuo, K., Xi, Y., Liu, S., AbouBechara, D., Melhem, R., Stanhope, K., Cummings, B., Graham, J., Bremer, A., Zhang, S., Lyssiotis, C. A., Zhang, Z. Y., Cantley, L. C., Havel, P. J. & Haj, F. G., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17360-17371 12 p.

Research output: Contribution to journalArticle

36 Scopus citations
2017

Covalent inhibition of protein tyrosine phosphatases

Ruddraraju, K. V. & Zhang, Z. Y., Jan 1 2017, In : Molecular BioSystems. 13, 7, p. 1257-1279 23 p.

Research output: Contribution to journalReview article

15 Scopus citations
2016

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Song, G. J., Jung, M., Kim, J. H., Park, H., Rahman, M. H., Zhang, S., Zhang, Z-Y., Park, D. H., Kook, H., Lee, I. K. & Suk, K., 2016, In : Journal of Neuroinflammation. 13, 1, 86.

Research output: Contribution to journalArticle

42 Scopus citations

EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells

Bai, S., Ingram, P., Chen, Y. C., Deng, N., Pearson, A., Niknafs, Y., O'Hayer, P., Wang, Y., Zhang, Z. Y., Boscolo, E., Bischoff, J., Yoon, E. & Buckanovich, R. J., Nov 1 2016, In : Cancer Research. 76, 21, p. 6396-6409 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Yu, Z. H. & Zhang, Z-Y., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1069-1091 23 p.

Research output: Contribution to journalReview article

28 Scopus citations