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  • G. David Roodman
2019

Paget’s disease of bone

Singer, F. R. & Roodman, G. D., Jan 1 2019, Principles of Bone Biology. Elsevier, p. 1601-1613 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Bortezomib and osteoclasts and osteoblasts

Krauze, M. T. & Roodman, G. D., Dec 1 2011, Bortezomib in the Treatment of Multiple Myeloma. Ghobrial, I., Richardson, P. & Anderson, K. (eds.). p. 43-52 10 p. (Milestones in Drug Therapy; vol. 37).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Developmental Aspects of Pagetic Osteoclasts

Galson, D. L., Sun, Q. & Roodman, G. D., May 9 2016, Advances in Pathobiology and Management of Paget's Disease of Bone. Elsevier Inc., p. 37-53 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Paget's disease of bone: Pathogenesis and treatment

Singer, F. R. & Roodman, G. D., Jan 1 2012, Bone-Metabolic Functions and Modulators. Springer London, p. 197-215 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2013

Multiple myeloma surveillance counterpoint: USA

Modi, N., Roodman, G. D. & Lentzsch, S., Jan 1 2013, Patient Surveillance After Cancer Treatment. Humana Press Inc., p. 489-492 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

CCN1: A sticky issue in myeloma

Roodman, G. D., Sep 25 2014, In : Blood. 124, 13, p. 2006-2008 3 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2017

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma

Hao, M., Franqui-Machin, R., Xu, H., Shaughnessy, J., Barlogie, B., Roodman, D., Quelle, D. E., Janz, S., Tomasson, M. H., Sanderson, R. D., Qiu, L., Frech, I., Tricot, G. & Zhan, F., Jul 1 2017, In : Leukemia. 31, 7, p. 1648-1650 3 p.

Research output: Contribution to journalLetter

9 Scopus citations
2015

Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption

Feng, R., Tong, Q., Xie, Z., Cheng, H., Wang, L., Lentzsch, S., Roodman, G. D. & Xie, X. Q., Dec 2015, In : Molecular Carcinogenesis. 54, 12, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

Bon, J., Kahloon, R., Zhang, Y., Xue, J., Fuhrman, C. R., Tan, J., Burger, M., Kass, D. J., Csizmadia, E., Otterbein, L., Chandra, D., Bhargava, A., Pilewski, J. M., Roodman, G. D., Sciurba, F. C. & Duncan, S. R., Sep 2014, In : PloS one. 9, 9, e105066.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Vitamin D and Paget's Disease

Kurihara, N. & Roodman, G. D., Dec 14 2017, Health, Disease and Therapeutics. Elsevier Inc., Vol. 2. p. 571-579 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2, p. 151-166.e1

Research output: Contribution to journalArticle

34 Scopus citations
2016

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

37 Scopus citations
2018

Osteoblast suppression in multiple myeloma bone disease

Adamik, J., Galson, D. L. & Roodman, G. D., Nov 2018, In : Journal of Bone Oncology. 13, p. 62-70 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

Bones in Multiple Myeloma: Imaging and Therapy

Zamagni, E., Cavo, M., Fakhri, B., Vij, R. & Roodman, D., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 638-646 9 p.

Research output: Contribution to journalReview article

10 Scopus citations
2019

Therapeutic targets in myeloma bone disease

Marino, S., Petrusca, D. N. & Roodman, G. D., 2019, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalReview article

3 Scopus citations
2013

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D. & Kurihara, N., Jun 1 2013, In : Journal of Bone and Mineral Research. 28, 6, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (Bolus) infusion schedule of alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms

Holkova, B., Kmieciak, M., Perkins, E. B., Bose, P., Baz, R. C., Roodman, G. D., Stuart, R. K., Ramakrishnan, V., Wan, W., Peer, C. J., Dawson, J., Kang, L., Honeycutt, C., Tombes, M. B., Shrader, E., Weir-Wiggins, C., Wellons, M., Sankala, H., Hogan, K. T., Colevas, A. D. & 6 others, Doyle, L. A., Figg, W. D., Coppola, D., Roberts, J. D., Sullivan, D. & Grant, S., Nov 15 2014, In : Clinical Cancer Research. 20, 22, p. 5652-5662 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2018

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
2011

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Role of osteocytes in multiple myeloma bone disease

Delgado-Calle, J., Bellido, T. & Roodman, G. D., 2014, In : Current Opinion in Supportive and Palliative Care. 8, 4, p. 407-413 7 p.

Research output: Contribution to journalReview article

36 Scopus citations

Whole-body low-dose computed tomography and advanced imaging techniques for multiple myeloma bone disease

Pianko, M. J., Terpos, E., Roodman, G. D., Divgi, C. R., Zweegman, S., Hillengass, J. & Lentzsch, S., Dec 1 2014, In : Clinical Cancer Research. 20, 23, p. 5888-5897 10 p.

Research output: Contribution to journalReview article

38 Scopus citations
2020

Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo

Miyagawa, K., Ohata, Y., Delgado-Calle, J., Teramachi, J., Zhou, H., Dempster, D. D., Subler, M. A., Windle, J. J., Chirgwin, J. M., David Roodman, G. & Kurihara, N., Mar 26 2020, In : JCI Insight. 5, 6, e133113.

Research output: Contribution to journalArticle

Open Access

Juvenile Paget's Disease From Heterozygous Mutation of SP7 Encoding Osterix (Specificity Protein 7, Transcription Factor SP7)

Whyte, M. P., Campeau, P. M., McAlister, W. H., Roodman, G. D., Kurihara, N., Nenninger, A., Duan, S., Gottesman, G. S., Bijanki, V. N., Sedighi, H., Veis, D. J. & Mumm, S., Aug 2020, In : Bone. 137, 115364.

Research output: Contribution to journalArticle

Summary of the 2019 Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Howard, A., Avigan, D., Bhutani, M., Cohen, A. D., Costa, L. J., Dhodapkar, M. V., Gay, F., Gormley, N., Green, D. J., Hillengass, J., Korde, N., Li, Z., Mailankody, S., Neri, P., Parekh, S., Pasquini, M. C., Puig, N., Roodman, G. D., Samur, M. K. & 7 others, Shah, N., Shah, U. A., Shi, Q., Spencer, A., Suman, V. J., Usmani, S. Z. & McCarthy, P. L., 2020, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalReview article

2018

Supportive care in multiple myeloma

Doshi, S. M., Noff, T. T. & David Roodman, G., Jan 1 2018, Neoplastic Diseases of the Blood. Springer International Publishing, p. 595-607 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K. S., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L. E., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F. A., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T. A., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

133 Scopus citations
2013

Osteoclasts: Potential target for blocking microenvironmental support of myeloma

Galson, D. L., D'Souza, S. & Roodman, G. D., Jan 1 2013, Advances in Biology and Therapy of Multiple Myeloma: Volume 1: Basic Science. Springer New York, p. 169-185 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2018

Paget disease of bone

Charles, J. F., Siris, E. S. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 713-720 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2013

Paget's Disease of Bone

Siris, E. S. & Roodman, G. D., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 659-668 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations
2011

Osteoblast function in myeloma

Roodman, G. D., Jan 1 2011, In : Bone. 48, 1, p. 135-140 6 p.

Research output: Contribution to journalReview article

46 Scopus citations
2012

Vitamin E: Good for the heart, bad for the bones?

Roodman, G. D., Apr 1 2012, In : Nature Medicine. 18, 4, p. 491-492 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

Combination of bendamustine, lenalidomide, anddexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: Results of phase 1/2 open-label, doseescalation study

Lentzsch, S., O'Sullivan, A., Kennedy, R. C., Abbas, M., Dai, L., Pregja, S. L., Burt, S., Boyiadzis, M., Roodman, G. D., Mapara, M. Y., Agha, M., Waas, J., Shuai, Y., Normolle, D. & Zonder, J. A., May 17 2012, In : Blood. 119, 20, p. 4608-4613 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Genes associate with abnormal bone cell activity in bone metastasis

Roodman, G. D., Dec 1 2012, In : Cancer and Metastasis Reviews. 31, 3-4, p. 569-578 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors

Yang, P., Myint, K. Z., Tong, Q., Feng, R., Cao, H., Almehizia, A. A., Alqarni, M. H., Wang, L., Bartlow, P., Gao, Y., Gertsch, J., Teramachi, J., Kurihara, N., Roodman, G. D., Cheng, T. & Xie, X. Q., Nov 26 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 9973-9987 15 p.

Research output: Contribution to journalArticle

32 Scopus citations
2011

Advances in the biology and treatment of bone disease in multiple myeloma

Raje, N. & Roodman, G. D., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1278-1286 9 p.

Research output: Contribution to journalReview article

117 Scopus citations
2018

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Mar 2018, In : The lancet oncology. 19, 3, p. 370-381 12 p.

Research output: Contribution to journalArticle

101 Scopus citations
2016

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

29 Scopus citations
2017

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L. I., Bellido, T. & Roodman, G. D., Jan 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Bone effects of cancer therapies: Pros and cons

Silbermann, R. & Roodman, G. D., Sep 1 2011, In : Current Opinion in Supportive and Palliative Care. 5, 3, p. 251-257 7 p.

Research output: Contribution to journalReview article

15 Scopus citations
2013

Mechanisms of Bone Destruction in Myeloma

Silbermann, R. & Roodman, G. D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1465-1478 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hematologic Malignancies and Bone

Silbermann, R. & Roodman, G. D., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 694-701 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2017

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

D'Souza, S., Del Prete, D., Jin, S., Sun, Q., Huston, A. J., Kostov, F. E., Sammut, B., Hong, C. S., Anderson, J. L., Patrene, K. D., Yu, S., Velu, C. S., Xiao, G., Grimes, H. L., Roodman, G. D. & Galson, D. L., Dec 22 2011, In : Blood. 118, 26, p. 6871-6880 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2014

Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma

Silbermann, R., Bolzoni, M., Storti, P., Guasco, D., Bonomini, S., Zhou, D., Wu, J., Anderson, J. L., Windle, J. J., Aversa, F., David Roodman, G. & Giuliani, N., Apr 2014, In : Leukemia. 28, 4, p. 951-954 4 p.

Research output: Contribution to journalLetter

33 Scopus citations
2016

The Role of the Immune System in the Effects of Cancer on Bone

Silbermann, R. & David Roodman, G., Jan 1 2016, Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc., p. 311-324 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2014

New drugs and novel mechanisms of action in multiple myeloma in 2013: A report from the International Myeloma Working Group (IMWG)

Ocio, E. M., Richardson, P. G., Rajkumar, S. V., Palumbo, A., Mateos, M. V., Orlowski, R., Kumar, S., Usmani, S., Roodman, D., Niesvizky, R., Einsele, H., Anderson, K. C., Dimopoulos, M. A., Avet-Loiseau, H., Mellqvist, U. H., Turesson, I., Merlini, G., Schots, R., Mccarthy, P., Bergsagel, L. & 14 others, Chim, C. S., Lahuerta, J. J., Shah, J., Reiman, A., Mikhael, J., Zweegman, S., Lonial, S., Comenzo, R., Chng, W. J., Moreau, P., Sonneveld, P., Ludwig, H., Durie, B. G. M. & Miguel, J. F. S., Mar 2014, In : Leukemia. 28, 3, p. 525-542 18 p.

Research output: Contribution to journalReview article

161 Scopus citations
2011

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms

Holkova, B., Perkins, E. B., Ramakrishnan, V., Tombes, M. B., Shrader, E., Talreja, N., Wellons, M. D., Hogan, K. T., Roodman, G. D., Coppola, D., Kang, L., Dawson, J., Stuart, R. K., Peer, C., Figg, W. D., Kolla, S., Doyle, A., Wright, J., Sullivan, D. M., Roberts, J. D. & 1 others, Grant, S., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3388-3397 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2014

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone

Teramachi, J., Zhou, H., Subler, M. A., Kitagawa, Y., Galson, D. L., Dempster, D. W., Windle, J. J., Kurihara, N. & Roodman, G. D., Jun 2014, In : Journal of Bone and Mineral Research. 29, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

14 Scopus citations