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  • Robert Harris
2016

Metabolic Regulation

Patel, M. S. & Harris, R. A., Jan 1 2016, Molecular Cell Biology. Elsevier Inc., Vol. 1. p. 288-297 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy

Rahman, M. H., Jha, M. K., Kim, J. H., Nam, Y., Lee, M. G., Go, Y., Harris, R. A., Park, D. H., Kook, H., Lee, I. K. & Suk, K., Mar 11 2016, In : Journal of Biological Chemistry. 291, 11, p. 6011-6025 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

O-GlcNAcylation of orphan nuclear receptor estrogen-related receptorγ promotes hepatic gluconeogenesis

Misra, J., Kim, D. K., Jung, Y. S., Kim, H. B., Kim, Y. H., Yoo, E. K., Kim, B. G., Kim, S., Lee, I. K., Harris, R. A., Kim, J. S., Lee, C. H., Cho, J. W. & Choi, H. S., Oct 1 2016, In : Diabetes. 65, 10, p. 2835-2848 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2019

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Pin, F., Novinger, L. J., Huot, J. R., Harris, R. A., Couch, M. E., O'Connell, T. M. & Bonetto, A., Jun 1 2019, In : FASEB Journal. 33, 6, p. 7778-7790 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. A. & Brustovetsky, N., 2016, In : Human molecular genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis

Go, Y., Jeong, J. Y., Jeoung, N. H., Jeon, J. H., Park, B. Y., Kang, H. J., Ha, C. M., Choi, Y. K., Lee, S. J., Ham, H. J., Kim, B. G., Park, K. G., Park, S. Y., Lee, C. H., Choi, C. S., Park, T. S., Paul Lee, W. N., Harris, R. & Lee, I. K., Oct 1 2016, In : Diabetes. 65, 10, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A. N., Mang, H., Plotkin, Z., Dube, S., Hutchins, G. D., Territo, P. R., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R. A., Daghe, P. C. & Sutton, T. A., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

12 Scopus citations

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiong, X., Wang, G., Tao, R., Wu, P., Kono, T., Li, K., Ding, W. X., Tong, X., Tersey, S. A., Harris, R. A., Mirmira, R. G., Evans-Molina, C. & Dong, X. C., Jan 1 2016, In : Diabetologia. 59, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

The SMILE transcriptional corepressor inhibits cAMP response element– binding protein (CREB)–mediated transactivation of gluconeogenic genes

Lee, J. M., Han, H. S., Jung, Y. S., Harris, R. A., Koo, S. H. & Choi, H. S., Aug 24 2018, In : Journal of Biological Chemistry. 293, 34, p. 13125-13133 9 p.

Research output: Contribution to journalArticle

E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells

Xu, S., Tao, J., Yang, L., Zhang, E., Boriboun, C., Zhou, J., Sun, T., Cheng, M., Huang, K., Shi, J., Dong, N., Liu, Q., Zhao, T. C., Qiu, H., Harris, R. A., Chandel, N. S., Losordo, D. W. & Qin, G., Mar 2018, In : Circulation research. 122, 5, p. 701-711 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression

Kim, Y. D., Hwang, S. L., Lee, E. J., Kim, H. M., Chung, M. J., Elfadl, A. K., Lee, S. E., Nedumaran, B., Harris, R. & Jeong, K. S., Mar 1 2017, In : Journal of Pineal Research. 62, 2, e12386.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation (Scientific Reports 5:16577; DOI:10.1038/srep16577)

Lee, S. J., Jeong, J. Y., Oh, C. J., Park, S., Kim, J. Y., Kim, H. J., Kim, N. D., Choi, Y. K., Do, J. Y., Go, Y., Ha, C. M., Choi, J. Y., Huh, S., Jeoung, N. H., Lee, K. U., Choi, H. S., Wang, Y., Park, K. G., Harris, R. A. & Lee, I. K., Jan 27 2016, In : Scientific reports. 6, 18552.

Research output: Contribution to journalComment/debate

2017

Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury

Oh, C. J., Ha, C. M., Choi, Y. K., Park, S., Choe, M. S., Jeoung, N. H., Huh, Y. H., Kim, H. J., Kweon, H. S., Lee, J. M., Lee, S. J., Jeon, J. H., Harris, R. A., Park, K. G. & Lee, I. K., Apr 1 2017, In : Kidney international. 91, 4, p. 880-895 16 p.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Insulin-Inducible SMILE inhibits hepatic gluconeogenesis

Lee, J. M., Seo, W. Y., Han, H. S., Oh, K. J., Lee, Y. S., Kim, D. K., Choi, S., Choi, B. H., Harris, R. A., Lee, C. H., Koo, S. H. & Choi, H. S., Jan 2016, In : Diabetes. 65, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis

Jang, J. E., Ko, M. S., Yun, J. Y., Kim, M. O., Kim, J. H., Park, H. S., Kim, A. R., Kim, H. J., Kim, B. J., Ahn, Y. E., Oh, J. S., Lee, W. J., Harris, R. A., Koh, E. H. & Lee, K. U., Sep 1 2016, In : Diabetes. 65, 9, p. 2516-2528 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2019

Pyruvate dehydrogenase kinase is a metabolic checkpoint for polarization of macrophages to the M1 phenotype

Min, B. K., Park, S., Kang, H. J., Kim, D. W., Ham, H. J., Ha, C. M., Choi, B. J., Lee, J. Y., Oh, C. J., Yoo, E. K., Kim, H. E., Kim, B. G., Jeon, J. H., Hyeon, D. Y., Hwang, D., Kim, Y. H., Lee, C. H., Lee, T., Jungwhan, K., Choi, Y. K. & 5 others, Park, K. G., Chawla, A., Lee, J., Harris, R. A. & Lee, I. K., 2019, In : Frontiers in immunology. 10, MAY, 944.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2016

The orphan nuclear receptor erraγ regulates hepatic cb1 receptor-mediated fibroblast growth factor 21 gene expression

Jung, Y. S., Lee, J. M., Kim, D. K., Lee, Y. S., Kim, K. S., Kim, Y. H., Kim, J., Lee, M. S., Lee, I. K., Kim, S. H., Cho, S. J., Jeong, W. I., Lee, C. H., Harris, R. A. & Choi, H. S., Jul 2016, In : PloS one. 11, 7, e0159425.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate

Noguchi, S., Kondo, Y., Ito, R., Katayama, T., Kazama, S., Kadota, Y., Kitaura, Y., Harris, R. A. & Shimomura, Y., Oct 12 2018, In : Biochemical and Biophysical Research Communications. 504, 4, p. 916-920 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2020

Induction of SIRT1 by melatonin improves alcohol-mediated oxidative liver injury by disrupting the CRBN-YY1-CYP2E1 signaling pathway

Lee, S. E., Koh, H., Joo, D. J., Nedumaran, B., Jeon, H. J., Park, C. S., Harris, R. A. & Kim, Y. D., Apr 1 2020, In : Journal of Pineal Research. 68, 3, e12638.

Research output: Contribution to journalArticle

2 Scopus citations
2019

PDK4 augments ER–mitochondria contact to dampen skeletal muscle insulin signaling during obesity

Thoudam, T., Ha, C. M., Leem, J., Chanda, D., Park, J. S., Kim, H. J., Jeon, J. H., Choi, Y. K., Liangpunsakul, S., Huh, Y. H., Kwon, T. H., Park, K. G., Harris, R. A., Park, K. S., Rhee, H. W. & Lee, I. K., Mar 1 2019, In : Diabetes. 68, 3, p. 571-586 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

PDK4 deficiency suppresses hepatic glucagon signaling by decreasing cAMP levels

Park, B. Y., Jeon, J. H., Go, Y., Ham, H. J., Kim, J. E., Yoo, E. K., Kwon, W. H., Jeoung, N. H., Jeon, Y. H., Koo, S. H., Kim, B. G., He, L., Park, K. G., Harris, R. A. & Lee, I. K., Oct 2018, In : Diabetes. 67, 10, p. 2054-2068 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2019

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., Hirschey, M. D. & 1 others, Cohen, H. Y., Dec 17 2019, In : Cell Reports. 29, 12, p. 4127-4143.e8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2020

Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases

Jeon, J. H., Thoudam, T., Choi, E. J., Kim, M. J., Harris, R. A. & Lee, I. K., 2020, (Accepted/In press) In : Journal of Diabetes Investigation.

Research output: Contribution to journalReview article

Open Access