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2017
6 Citations (Scopus)

Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers

Vemula, H., Kitase, Y., Ayon, N. J., Bonewald, L. & Gutheil, W. G., Jan 1 2017, In : Analytical Biochemistry. 516, p. 75-85 11 p.

Research output: Contribution to journalArticle

Aminobutyrates
Deconvolution
Isomers
gamma-Aminobutyric Acid
High Pressure Liquid Chromatography
27 Citations (Scopus)

The Role of the Osteocyte in Bone and Nonbone Disease

Bonewald, L., Mar 1 2017, In : Endocrinology and Metabolism Clinics of North America. 46, 1, p. 1-18 18 p.

Research output: Contribution to journalReview article

Osteocytes
Bone Diseases
Bone Matrix
Myocardium
Kidney
2016
6 Citations (Scopus)

Hypoxia mediates osteocyte ORP150 expression and cell death in vitro

Montesi, M., Jähn, K., Bonewald, L., Stea, S., Bordini, B. & Beraudi, A., Nov 1 2016, In : Molecular Medicine Reports. 14, 5, p. 4248-4254 7 p.

Research output: Contribution to journalArticle

Osteocytes
Cell death
Bone
Cell Death
Apoptosis
56 Citations (Scopus)
Catenins
Wnt Signaling Pathway
Osteogenesis
Tooth
Bone
2018
28 Citations (Scopus)

β-aminoisobutyric Acid, L-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M. & Bonewald, L., Feb 6 2018, In : Cell Reports. 22, 6, p. 1531-1544 14 p.

Research output: Contribution to journalArticle

Aminoisobutyric Acids
Osteocytes
Muscle
Reactive Oxygen Species
Muscles
2019

Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-ҡB activity

Miyazaki, T., Zhao, Z., Ichihara, Y., Yoshino, D., Imamura, T., Sawada, K., Hayano, S., Kamioka, H., Mori, S., Hirata, H., Araki, K., Kawauchi, K., Shigemoto, K., Tanaka, S., Bonewald, L. F., Honda, H., Shinohara, M., Nagao, M., Ogata, T., Harada, I. & 1 others, Sawada, Y., Sep 25 2019, In : Science Advances. 5, 9, eaau7802.

Research output: Contribution to journalArticle

Open Access
homeostasis
bones
nuclei
fluids
unloading
1 Citation (Scopus)

Characterization of a novel murine Sost ER T2 Cre model targeting osteocytes

Maurel, D. B., Matsumoto, T., Vallejo, J. A., Johnson, M. L., Dallas, S. L., Kitase, Y., Brotto, M., Wacker, M. J., Harris, M. A., Harris, S. E. & Bonewald, L., Dec 1 2019, In : Bone Research. 7, 1, 6.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Tamoxifen
Injections
Bone and Bones
Muscles
2018
16 Citations (Scopus)

Physiological and pathological osteocytic osteolysis

Tsourdi, E., Jähn, K., Rauner, M., Busse, B. & Bonewald, L., Sep 1 2018, In : Journal of Musculoskeletal Neuronal Interactions. 18, 3, p. 292-303 12 p.

Research output: Contribution to journalReview article

Osteocytes
Osteolysis
Osteoclasts
Osteoblasts
Bone and Bones
2016
8 Citations (Scopus)

The Cementocyte - An Osteocyte Relative?

Zhao, N., Foster, B. L. & Bonewald, L., Jul 1 2016, In : Journal of Dental Research. 95, 7, p. 734-741 8 p.

Research output: Contribution to journalReview article

Dental Cementum
Osteocytes
Tooth
Odontoblasts
Tooth Root
13 Citations (Scopus)

Long-term bone regeneration, mineralization and angiogenesis in rat calvarial defects implanted with strong porous bioactive glass (13-93) scaffolds

Lin, Y., Xiao, W., Liu, X., Bal, B. S., Bonewald, L. & Rahaman, M. N., Jan 15 2016, In : Journal of Non-Crystalline Solids. 432, p. 120-129 10 p.

Research output: Contribution to journalArticle

angiogenesis
Bioactive glass
activity (biology)
regeneration
Scaffolds
2017
12 Citations (Scopus)

ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass

Barreto, R., Kitase, Y., Matsumoto, T., Pin, F., Colston, K. C., Couch, K. E., O'Connell, T. M., Couch, M. E., Bonewald, L. & Bonetto, A., Dec 1 2017, In : Scientific Reports. 7, 1, 14470.

Research output: Contribution to journalArticle

Bone and Bones
Drug Therapy
Muscles
Femur
Spine
2018
1 Citation (Scopus)

Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism

Yajima, A., Tsuchiya, K., Bonewald, L., Inaba, M., Tominaga, Y., Tanizawa, T., Ito, A. & Nitta, K., Feb 28 2018, (Accepted/In press) In : Osteoporosis International. p. 1-7 7 p.

Research output: Contribution to journalArticle

Secondary Hyperparathyroidism
Bone Diseases
Electrons
Bone and Bones
Osteocytes
2016
1 Citation (Scopus)

Potential of bioact1ve glass scaffolds as implants for structural bone repair

Rahaman, M. N., Bal, B. S. & Bonewald, L., 2016, Advances in Bioceramics and Porous Ceramics VIII - A Collection of Papers Presented at the 39th International Conference on Advanced Ceramics and Composites. 5 ed. American Ceramic Society, Vol. 36. p. 3-15 13 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Scaffolds
Bone
Repair
Glass
Defects
2018

Osteocytes

Bonewald, L., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 38-45 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteocytes
Bone
Bone Diseases
Osteoblasts
Bone and Bones
2016
19 Citations (Scopus)

Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) gene in osteocytes stimulates soleus muscle regeneration and increased size and contractile force with age

Gorski, J. P., Huffman, N. T., Vallejo, J., Brotto, L., Chittur, S. V., Breggia, A., Stern, A., Huang, J., Mo, C., Seidah, N. G., Bonewald, L. & Brotto, M., Feb 26 2016, In : Journal of Biological Chemistry. 291, 9, p. 4308-4322 15 p.

Research output: Contribution to journalArticle

Osteocytes
Muscle
Regeneration
Skeletal Muscle
Genes
2019

Erratum: Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (Cell (2018) 175(7) (1756–1768.e17), (S0092867418313345), (10.1016/j.cell.2018.10.025))

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V. J. A., Novick, S. J., Strutzenberg, T. S., Pascal, B. D., Le, P. T., Brooks, D. J., Roche, A. M., Gerber, K. K., Mattheis, L., Chen, W., Tu, H., Bouxsein, M. L. & 5 others, Griffin, P. R., Baron, R., Rosen, C. J., Bonewald, L. F. & Spiegelman, B. M., Jul 11 2019, In : Cell. 178, 2, p. 507-508 2 p.

Research output: Contribution to journalComment/debate

Open Access
Integrins
Bone
Fats
Bone and Bones
Actins
3 Citations (Scopus)

A Novel Osteogenic Cell Line That Differentiates Into GFP-Tagged Osteocytes and Forms Mineral With a Bone-Like Lacunocanalicular Structure

Wang, K., Le, L., Chun, B. M., Tiede-Lewis, L. A. M., Shiflett, L. A., Prideaux, M., Campos, R. S., Veno, P. A., Xie, Y., Dusevich, V., Bonewald, L. F. & Dallas, S. L., Jan 1 2019, In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteocytes
Minerals
Bone and Bones
Cell Line
Clone Cells
2017
18 Citations (Scopus)

Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo

Jähn, K., Kelkar, S., Zhao, H., Xie, Y., Tiede-Lewis, L. A. M., Dusevich, V., Dallas, S. L. & Bonewald, L., Aug 1 2017, In : Journal of Bone and Mineral Research. 32, 8, p. 1761-1772 12 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Osteocytes
Osteoclasts
Vacuolar Proton-Translocating ATPases
Calcium
45 Citations (Scopus)

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

Qin, Y., Peng, Y., Zhao, W., Pan, J., Ksiezak-Reding, H., Cardozo, C., Wu, Y., Pajevic, P. D., Bonewald, L., Bauman, W. A. & Qin, W., Jan 1 2017, In : Journal of Biological Chemistry. 292, 26, p. 11021-11033 13 p.

Research output: Contribution to journalArticle

Myostatin
Osteocytes
MicroRNAs
Muscle
Bone
2019
9 Citations (Scopus)

Use it or lose it to age: A review of bone and muscle communication

Bonewald, L., Mar 1 2019, In : Bone. 120, p. 212-218 7 p.

Research output: Contribution to journalArticle

Communication
Bone and Bones
Muscles
Dinoprostone
Alzheimer Disease
2018
11 Citations (Scopus)

Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs

Lu, Y., Kamel-El Sayed, S. A., Wang, K., Tiede-Lewis, L. M., Grillo, M. A., Veno, P. A., Dusevich, V., Phillips, C. L., Bonewald, L. & Dallas, S. L., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Collagen Type I
Osteoblasts
Collagen
Fibronectins
Connective Tissue
2019

Multi-staged regulation of lipid signaling mediators during myogenesis by COX-1/2 pathways

Mo, C., Wang, Z., Bonewald, L. & Brotto, M., Sep 2019, In : International journal of molecular sciences. 20, 18, 4326.

Research output: Contribution to journalArticle

Open Access
Cyclooxygenase 1
Muscle Development
Cyclooxygenase 2
Lipids
lipids

Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells

Huang, J., Wang, K., Shiflett, L. A., Brotto, L., Bonewald, L. F., Wacker, M. J., Dallas, S. L. & Brotto, M., Dec 17 2019, In : Cell Cycle. 18, 24, p. 3562-3580 19 p.

Research output: Contribution to journalArticle

Open Access
Fibroblast Growth Factor 9
Muscle Cells
Myoblasts
Fibroblast Growth Factor 10
Myostatin

Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes

Pacicca, D. M., Brown, T., Watkins, D., Kover, K., Yan, Y., Prideaux, M. & Bonewald, L., Dec 1 2019, In : Scientific reports. 9, 1, 17353.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Glucose
Bone and Bones
Streptozocin
Messenger RNA
4 Citations (Scopus)

Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients

Pin, F., Bonetto, A., Bonewald, L. F. & Klein, G. L., Aug 7 2019, In : Frontiers in Endocrinology. 10, 543.

Research output: Contribution to journalArticle

Open Access
pamidronate
Muscular Atrophy
Pediatrics
Serum
Skeletal Muscle Fibers
2016
74 Citations (Scopus)

Identification of Senescent Cells in the Bone Microenvironment

Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L., Pignolo, R. J., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Phenotype
Satellite DNA
Cell Aging
2018
41 Citations (Scopus)

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V. J. A., Novick, S. J., Strutzenberg, T. S., Pascal, B. D., Le, P. T., Brooks, D. J., Roche, A. M., Gerber, K. K., Mattheis, L., Chen, W., Tu, H., Bouxsein, M. L. & 5 others, Griffin, P. R., Baron, R., Rosen, C. J., Bonewald, L. & Spiegelman, B. M., Dec 13 2018, In : Cell. 175, 7, p. 1756-1768.e17

Research output: Contribution to journalArticle

Integrins
Bone
Fats
Bone and Bones
Osteocytes
2017
17 Citations (Scopus)

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Medina-Gomez, C., Kemp, J. P., Dimou, N. L., Kreiner, E., Chesi, A., Zemel, B. S., Bønnelykke, K., Boer, C. G., Ahluwalia, T. S., Bisgaard, H., Evangelou, E., Heppe, D. H. M., Bonewald, L., Gorski, J. P., Ghanbari, M., Demissie, S., Duque, G., Maurano, M. T., Kiel, D. P., Hsu, Y. H. & 14 others, Van Der Eerden, B. C. J., Ackert-Bicknell, C., Reppe, S., Gautvik, K. M., Raastad, T., Karasik, D., Van De Peppel, J., Jaddoe, V. W. V., Uitterlinden, A. G., Tobias, J. H., Grant, S. F. A., Bagos, P. G., Evans, D. M. & Rivadeneira, F., Dec 1 2017, In : Nature Communications. 8, 1, 121.

Research output: Contribution to journalArticle

Pediatrics
genome
Genome-Wide Association Study
loci
Bone Density
2016
11 Citations (Scopus)

Skeletal muscle, but not cardiovascular function, is altered in a mouse model of autosomal recessive hypophosphatemic rickets

Wacker, M. J., Touchberry, C. D., Silswal, N., Brotto, L., Elmore, C. J., Bonewald, L., Andresen, J. & Brotto, M., 2016, In : Frontiers in Physiology. 7, MAY, 173.

Research output: Contribution to journalArticle

Hypophosphatemic Rickets
Skeletal Muscle
Muscles
Osteomalacia
Myocardium
2017

Osteocyte Biology

Bellido, T., Pajevic, P. D. & Bonewald, L., Oct 31 2017, Genetics of Bone Biology and Skeletal Disease: Second Edition. Elsevier Inc., p. 227-240 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteocytes
Bone and Bones
Bone Matrix
Endocrine Cells
Bone Diseases
2018
10 Citations (Scopus)

Growth of ovarian cancer xenografts causes loss of muscle and bone mass: A new model for the study of cancer cachexia

Pin, F., Barreto, R., Kitase, Y., Mitra, S., Erne, C. E., Novinger, L. J., Zimmers, T., Couch, M. E., Bonewald, L. & Bonetto, A., Jan 1 2018, (Accepted/In press) In : Journal of Cachexia, Sarcopenia and Muscle.

Research output: Contribution to journalArticle

Cachexia
Heterografts
Ovarian Neoplasms
Bone and Bones
Muscles
13 Citations (Scopus)

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation

Morrell, A. E., Brown, G. N., Robinson, S. T., Sattler, R. L., Baik, A. D., Zhen, G., Cao, X., Bonewald, L., Jin, W., Kam, L. C. & Guo, X. E., Dec 1 2018, In : Bone Research. 6, 1, 6.

Research output: Contribution to journalArticle

Osteocytes
Lysosomal-Associated Membrane Protein 1
Osteogenesis
Neomycin
Bone and Bones
9 Citations (Scopus)

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression

Colditz, J., Thiele, S., Baschant, U., Niehrs, C., Bonewald, L. F., Hofbauer, L. C. & Rauner, M., Sep 1 2018, In : Journal of Bone and Mineral Research. 33, 9, p. 1698-1707 10 p.

Research output: Contribution to journalArticle

Osteogenesis
Bone and Bones
Bone Remodeling
Cell Lineage
Osteoblasts
2017
19 Citations (Scopus)

Degeneration of the osteocyte network in the C57BL/6 mouse model of aging

Tiede-Lewis, L. A. M., Xie, Y., Hulbert, M. A., Campos, R., Dallas, M. R., Dusevich, V., Bonewald, L. & Dallas, S. L., Jan 1 2017, In : Aging. 9, 10, p. 2187-2205 19 p.

Research output: Contribution to journalArticle

Osteocytes
Inbred C57BL Mouse
Bone and Bones
Dendrites
Porosity
2016
18 Citations (Scopus)

Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition

Yamamoto, H., Ramos-Molina, B., Lick, A. N., Prideaux, M., Albornoz, V., Bonewald, L. & Lindberg, I., Mar 1 2016, In : Bone. 84, p. 120-130 11 p.

Research output: Contribution to journalArticle

Osteocytes
Furin
Osteoblasts
Proprotein Convertase 2
Proprotein Convertases
9 Citations (Scopus)

Isolation and Functional Analysis of an Immortalized Murine Cementocyte Cell Line, IDG-CM6

Zhao, N., Nociti, F. H., Duan, P., Prideaux, M., Zhao, H., Foster, B. L., Somerman, M. J. & Bonewald, L., Feb 1 2016, In : Journal of Bone and Mineral Research. 31, 2, p. 430-442 13 p.

Research output: Contribution to journalArticle

Osteocytes
Dental Cementum
Osteoprotegerin
Cell Line
Tooth Root
6 Citations (Scopus)

Beta-catenin haplo insufficient male mice do not lose bone in response to hindlimb unloading

Maurel, D. B., Duan, P., Farr, J., Cheng, A. L., Johnson, M. L. & Bonewald, L., Jul 1 2016, In : PLoS One. 11, 7, e0158381.

Research output: Contribution to journalArticle

Hindlimb Suspension
beta Catenin
Unloading
Bone
Catenins