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2018
4 Citations (Scopus)

(-)-phenserine and inhibiting pre-programmed cell death: In pursuit of a novel intervention for Alzheimer’s disease

Becker, R. E., Greig, N. H., Lahiri, D., Bledsoe, J., Majercik, S., Ballard, C., Aarsland, D., Schneider, L. S., Flanagan, D., Govindarajan, R., Sano, M., Ferrucci, L. & Kapogiannis, D., Jan 1 2018, In : Current Alzheimer Research. 15, 9, p. 883-891 9 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Cell Death
Clinical Trials
Animal Models
phenserine
3 Citations (Scopus)

A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling

Konar, A., Kumar, A., Maloney, B., Lahiri, D. & Thakur, M. K., Dec 1 2018, In : Scientific Reports. 8, 1, 9928.

Research output: Contribution to journalArticle

Microtubule Proteins
Cyclic AMP Response Element-Binding Protein
Serine Proteases
Cyclic AMP-Dependent Protein Kinases
Dendrites
2019
1 Citation (Scopus)

APPealing for a role in cellular iron efflux

Lahiri, D., Maloney, B. & Wang, R., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, 1 p.

Research output: Contribution to journalLetter

Iron
2016
47 Citations (Scopus)

Epigenetics of dementia: understanding the disease as a transformation rather than a state

Maloney, B. & Lahiri, D., Jun 1 2016, In : The Lancet. Neurology. 15, 7, p. 760-774 15 p.

Research output: Contribution to journalReview article

Epigenomics
Dementia
Genome-Wide Association Study
Alzheimer Disease
Therapeutics
2019
1 Citation (Scopus)
Open Access
Leucine Zippers
Glucocorticoids
Lipopolysaccharides
Glucocorticoid Receptors
Innate Immunity
2018

Understanding healthy protective mechanisms against old age

Lahiri, D., Jan 1 2018, In : Current Aging Science. 11, 1, p. 2-3 2 p.

Research output: Contribution to journalEditorial

2019

Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs

Niculescu, A. B., Le-Niculescu, H., Roseberry, K., Wang, S., Hart, J., Kaur, A., Robertson, H., Jones, T., Strasburger, A., Williams, A., Kurian, S. M., Lamb, B., Shekhar, A., Lahiri, D. K. & Saykin, A. J., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Drug Repositioning
Pharmacogenetics
Alzheimer Disease
Biomarkers
Short-Term Memory
2016

Translational Alzheimer’s disease research

Huang, Y. & Lahiri, D., Mar 1 2016, In : Current Alzheimer Research. 13, 3, p. 214 1 p.

Research output: Contribution to journalArticle

Translational Medical Research
Alzheimer Disease
Research
5 Citations (Scopus)

Novel nuclear factor-KappaB targeting peptide suppresses β-amyloid induced inflammatory and apoptotic responses in neuronal cells

Srinivasan, M., Bayon, B., Chopra, N. & Lahiri, D., Oct 1 2016, In : PLoS One. 11, 10, e0160314.

Research output: Contribution to journalArticle

Leucine Zippers
transcription factor NF-kappa B
leucine zipper
Neurology
transcriptional activation
2019

Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD

Lahiri, D., Jan 1 2019, In : Current Alzheimer research. 16, 4, p. 279-280 2 p.

Research output: Contribution to journalEditorial

Open Access
Alzheimer Disease
Clinical Trials
Pharmaceutical Preparations
2017
13 Citations (Scopus)

Potential for stem cells therapy in alzheimer’s disease: Do neurotrophic factors play critical role?

Bali, P., Lahiri, D., Banik, A., Nehru, B. & Anand, A., Feb 1 2017, In : Current Alzheimer Research. 14, 2, p. 208-220 13 p.

Research output: Contribution to journalReview article

Nerve Growth Factors
Stem Cell Transplantation
Cell- and Tissue-Based Therapy
Alzheimer Disease
Stem Cells
2019
1 Citation (Scopus)
Alzheimer Disease
Neoplasms
Drug Repositioning
Contact Inhibition
Health Priorities
2017
3 Citations (Scopus)

Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism

Erickson, C. A., Ray, B., Wink, L. K., Bayon, B. L., Pedapati, E. V., Shaffer, R., Schaefer, T. L. & Lahiri, D., Jan 1 2017, In : Journal of Psychiatric Research. 84, p. 153-160 8 p.

Research output: Contribution to journalArticle

Autistic Disorder
Phosphotransferases
Lymphocytes
Autism
Activation
2016
7 Citations (Scopus)

Analysis of peripheral amyloid precursor protein in Angelman Syndrome

Erickson, C. A., Wink, L. K., Baindu, B., Ray, B., Schaefer, T. L., Pedapati, E. V. & Lahiri, D., Sep 1 2016, In : American Journal of Medical Genetics, Part A. 170, 9, p. 2334-2337 4 p.

Research output: Contribution to journalArticle

Angelman Syndrome
Amyloid beta-Protein Precursor
Ubiquitin-Protein Ligases
Chromosome Duplication
Fragile X Syndrome
2019

Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta)

Duffy, K. B., Ray, B., Lahiri, D., Tilmont, E. M., Tinkler, G. P., Herbert, R. L., Greig, N. H., Ingram, D. K., Ottinger, M. A. & Mattison, J. A., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Macaca mulatta
Amyloid
Norepinephrine
Alzheimer Disease
Locus Coeruleus
2016
18 Citations (Scopus)

Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism

Westmark, C. J., Sokol, D., Maloney, B. & Lahiri, D., Oct 1 2016, In : Molecular Psychiatry. 21, 10, p. 1333-1341 9 p.

Research output: Contribution to journalReview article

Fragile X Syndrome
Amyloid beta-Protein Precursor
Autistic Disorder
Protein Precursors
Amyloid Precursor Protein Secretases
2017
1 Citation (Scopus)

A cardinal sin when researching neuropsin/KLK8: Thou shalt validate antibodies

Lahiri, D., Konar, A., Thakur, M. K. & Maloney, B., 2017, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Antibodies
2 Citations (Scopus)
Wnt Signaling Pathway
Pulmonary Fibrosis
PPAR gamma
Gene Expression Regulation
MicroRNAs
2018
13 Citations (Scopus)

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

Long, J. M., Maloney, B., Rogers, J. T. & Lahiri, D., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
5' Untranslated Regions
MicroRNAs
Alzheimer Disease
Up-Regulation
2019
1 Citation (Scopus)

Novel contribution of secreted amyloid-β precursor protein to white matter brain enlargement in autism spectrum disorder

Sokol, D., Maloney, B., Westmark, C. J. & Lahiri, D., Jan 1 2019, In : Frontiers in Psychiatry. 10, APR, 165.

Research output: Contribution to journalReview article

Open Access
Amyloid beta-Protein Precursor
Autistic Disorder
Amyloid Precursor Protein Secretases
Brain
Alzheimer Disease
2016
9 Citations (Scopus)

Transgenerational latent early-life associated regulation unites environment and genetics across generations

Lahiri, D., Maloney, B., Bayon, B. L., Chopra, N., White, F., Greig, N. H. & Nurnberger, J., Mar 1 2016, In : Epigenomics. 8, 3, p. 373-387 15 p.

Research output: Contribution to journalArticle

Environmental Exposure
Epigenomics
Gene Expression
Pregnancy
14 Citations (Scopus)
Fragile X Syndrome
Protein Precursors
Brain
Serum Amyloid A Protein
Amyloid Precursor Protein Secretases
2020

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Chopra, N., Wang, R., Maloney, B., Nho, K., Beck, J. S., Pourshafie, N., Niculescu, A., Saykin, A. J., Rinaldi, C., Counts, S. E. & Lahiri, D. K., Jan 1 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
tau Proteins
Amyloid beta-Protein Precursor
MicroRNAs
Alzheimer Disease
Enzymes
2016
20 Citations (Scopus)

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

Shah, K. & Lahiri, D., Mar 5 2016, (Accepted/In press) In : Molecular Neurobiology. p. 1-14 14 p.

Research output: Contribution to journalArticle

Cytoskeleton
Microtubules
Neuronal Plasticity
Brain
Stathmin
9 Citations (Scopus)

Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease

Srinivasan, M. & Lahiri, D., Nov 26 2016, (Accepted/In press) In : Molecular Neurobiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Leucine Zippers
Central Nervous System Diseases
Glucocorticoids
Health
Glucocorticoid Receptors
3 Citations (Scopus)

Potential for stem cells therapy in Alzheimer’s disease: Do neurotrophic factors play critical role?

Bali, P., Lahiri, D., Banik, A., Nehru, B. & Anand, A., Sep 1 2016, In : Current Alzheimer Research. 13, 9

Research output: Contribution to journalArticle

Nerve Growth Factors
Stem Cell Transplantation
Cell- and Tissue-Based Therapy
Alzheimer Disease
Stem Cells
2018
1 Citation (Scopus)
Leucine Zippers
NF-kappa B
Glucocorticoids
Alzheimer Disease
Gliosis
2017
39 Citations (Scopus)

Targeting tumor necrosis factor alpha for Alzheimer’s disease

Decourt, B., Lahiri, D. & Sabbagh, M. N., Apr 1 2017, In : Current Alzheimer Research. 14, 4, p. 412-425 14 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Tumor Necrosis Factor-alpha
Pharmacology
Pathology
Inflammation
2019

Moon missions spark the human imagination

Lahiri, D. K., Nov 1 2019, In : Science. 366, 6465, 1 p.

Research output: Contribution to journalLetter

Astronauts
Imagination
Space Flight
2018
14 Citations (Scopus)

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin

Venkataramani, V., Doeppner, T. R., Willkommen, D., Cahill, C. M., Xin, Y., Ye, G., Liu, Y., Southon, A., Aron, A., Au-Yeung, H. Y., Huang, X., Lahiri, D., Wang, F., Bush, A. I., Wulf, G. G., Ströbel, P., Michalke, B. & Rogers, J. T., Jan 1 2018, (Accepted/In press) In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Apoferritins
Amyloid beta-Protein Precursor
Manganese
Iron
Oxidative stress
2017

When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author

Lahiri, D., Maloney, B. & Sambamurti, K., Nov 30 2017, In : Gene. 635, p. 46-47 2 p.

Research output: Contribution to journalLetter

Breast Neoplasms
Biomedical Research
Clinical Trials
Cell Line
Genes
2018
1 Citation (Scopus)

Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis

Maloney, B., Bayon, B. L., Zawia, N. H. & Lahiri, D., Sep 1 2018, In : NeuroToxicology. 68, p. 126-132 7 p.

Research output: Contribution to journalComment/debate

Water
Remediation
Social Change
Research
Epigenomics
2019

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

Konar, A., Gupta, R., Shukla, R. K., Maloney, B., Khanna, V. K., Wadhwa, R., Lahiri, D. K. & Thakur, M. K., Dec 1 2019, In : Scientific reports. 9, 1, 13990.

Research output: Contribution to journalArticle

Open Access
Withania
Muscarinic M1 Receptors
Kallikreins
Muscarinic Receptors
Scopolamine Hydrobromide
Open Access
Neuroblastoma
Lithium
Alzheimer Disease
RNA
Genes