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2016
4 Citations (Scopus)

Comparative analysis of protein tyrosine phosphatases regulating microglial activation

Song, G. J., Kim, J., Kim, J. H., Song, S., Park, H., Zhang, Z-Y. & Suk, K., Oct 1 2016, In : Experimental Neurobiology. 25, 5, p. 252-261 10 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Lipopolysaccharides
Neuroglia
Brain
Microglia

Current status of PTP-based therapeutics

He, R. & Zhang, Z-Y., Jan 1 2016, Protein Tyrosine Phosphatases in Cancer. Springer New York, p. 335-353 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein Tyrosine Phosphatases
Phosphorylation
Tyrosine
Tumors
Neoplasms
18 Citations (Scopus)

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus

Wang, J., Mizui, M., Zeng, L. F., Bronson, R., Finnell, M., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z-Y. & Kontaridis, M. I., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2077-2092 16 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Inbred MRL lpr Mouse
Interleukin-17
Autoimmunity
SH2 Domain-Containing Protein Tyrosine Phosphatases
2017
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
2018
17 Citations (Scopus)

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Yu, Z. H. & Zhang, Z-Y., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1069-1091 23 p.

Research output: Contribution to journalReview article

Protein Tyrosine Phosphatases
Phosphorylation
Cell signaling
Tyrosine
Oligomerization
2016
21 Citations (Scopus)

EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells

Bai, S., Ingram, P., Chen, Y. C., Deng, N., Pearson, A., Niknafs, Y., O'Hayer, P., Wang, Y., Zhang, Z-Y., Boscolo, E., Bischoff, J., Yoon, E. & Buckanovich, R. J., Nov 1 2016, In : Cancer Research. 76, 21, p. 6396-6409 14 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Maintenance
Neoplastic Stem Cells
Neoplasm Metastasis
Neoplasms
2018
5 Citations (Scopus)

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z-Y. & Deng, Q., Mar 29 2018, In : Frontiers in Immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

Endotoxemia
Zebrafish
Inflammation
Myeloid Differentiation Factor 88
Protein Tyrosine Phosphatases
2016
34 Citations (Scopus)

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Song, G. J., Jung, M., Kim, J. H., Park, H., Rahman, M. H., Zhang, S., Zhang, Z-Y., Park, D. H., Kook, H., Lee, I. K. & Suk, K., 2016, In : Journal of Neuroinflammation. 13, 1, 86.

Research output: Contribution to journalArticle

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Nitric Oxide
Brain
Microglia
Encephalitis
2017
5 Citations (Scopus)

Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia

Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z-Y. & Liu, Y., Mar 1 2017, In : Leukemia. 31, 3, p. 751-754 4 p.

Research output: Contribution to journalLetter

T-Cell Leukemia
Phosphoric Monoester Hydrolases
2016

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J-T., Feb 11 2016, In : Oncogene. 35, 6, p. 802 1 p.

Research output: Contribution to journalArticle

Oncogenes
Neoplasm Metastasis
Gene Expression
DNA
Growth
2017
6 Citations (Scopus)

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M., Kapur, R., Kaplan, M., Daniel Lacorazza, H., Zhang, Z-Y. & Liu, Y., Apr 1 2017, In : Stem Cells. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Hematopoietic Stem Cells
T-Lymphocytes
Cell Differentiation
Stem Cell Factor
2016
5 Citations (Scopus)

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Li, Y., Xia, G., Guo, Q., Wu, L., Chen, S., Yang, Z., Wang, W., Zhang, Z-Y., Zhou, X. & Jiang, Z. X., 2016, In : MedChemComm. 7, 8, p. 1672-1680 9 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Magnetic resonance
Magnetic Resonance Spectroscopy
Fluorine
Imaging techniques
2018
3 Citations (Scopus)

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z-Y., Adibekian, A. & Dai, M., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17465-17473 9 p.

Research output: Contribution to journalArticle

Abies
Phosphatases
Molecules
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Proteins
2017
37 Citations (Scopus)

Drugging the undruggable: Therapeutic potential of targeting protein tyrosine phosphatases

Zhang, Z-Y., Jan 1 2017, In : Accounts of Chemical Research. 50, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Phosphorylation
Tyrosine
Medical problems
Oncology
2018
10 Citations (Scopus)

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Zehender, A., Huang, J., Györfi, A. H., Matei, A. E., Trinh-Minh, T., Xu, X., Li, Y. N., Chen, C. W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z-Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. & Distler, J. H. W., Dec 1 2018, In : Nature Communications. 9, 1, 3259.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
fibrosis
phosphatases
tyrosine
fibroblasts
2016
43 Citations (Scopus)

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

Hamerman, J. A., Pottle, J., Ni, M., He, Y., Zhang, Z-Y. & Buckner, J. H., Jan 1 2016, In : Immunological Reviews. 269, 1, p. 212-227 16 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Myeloid Cells
Autoimmune Diseases
Cytokines
Autoimmunity
2017
10 Citations (Scopus)

Covalent inhibition of protein tyrosine phosphatases

Ruddraraju, K. V. & Zhang, Z-Y., 2017, In : Molecular BioSystems. 13, 7, p. 1257-1279 23 p.

Research output: Contribution to journalReview article

Protein Tyrosine Phosphatases
Tyrosine
Isothiocyanates
Epoxy Compounds
Ketones
15 Citations (Scopus)

Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

Yamashita, N., Joshi, R., Zhang, S., Zhang, Z-Y. & Kuruvilla, R., Sep 25 2017, In : Developmental Cell. 42, 6, p. 626-639.e5

Research output: Contribution to journalArticle

Nerve Growth Factor Receptors
Transcytosis
trkA Receptor
Carisoprodol
Axons
2016
18 Citations (Scopus)

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Zhang, R. Y., Yu, Z. H., Zeng, L., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. & Zhang, Z-Y., 2016, In : Oncotarget. 7, 45, p. 73817-73829 13 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Melanoma
Therapeutics
Cell Movement
Neoplasms
2018
4 Citations (Scopus)

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Xu, J., Lee, S. S. Y., Seo, H., Pang, L., Jun, Y., Zhang, R. Y., Zhang, Z-Y., Kim, P., Lee, W., Kron, S. J. & Yeo, Y., Jan 1 2018, (Accepted/In press) In : Small. 1803601.

Research output: Contribution to journalArticle

Quinic Acid
Selectins
Drug delivery
Nanoparticles
Tumors
2019
6 Citations (Scopus)

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z-Y., Tsao, M. S., Ikura, M. & Ohh, M., Dec 1 2019, In : Nature Communications. 10, 1, 224.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
GTP Phosphohydrolases
Conformations
switches

Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin

Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N. G., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z. Y. & Matei, D., Jun 1 2019, In : Molecular cancer therapeutics. 18, 6, p. 1057-1068 12 p.

Research output: Contribution to journalArticle

Fibronectins
Ovarian Neoplasms
Cell-Matrix Junctions
Interferometry
Focal Adhesion Protein-Tyrosine Kinases
2016
6 Citations (Scopus)

Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis

Bai, Y., Zhou, H. M., Zhang, L., Dong, Y., Zeng, Q., Shou, W. & Zhang, Z-Y., Sep 26 2016, In : Scientific Reports. 6, 34211.

Research output: Contribution to journalArticle

Spermatogenesis
Phosphoric Monoester Hydrolases
Liver
Testis
PTEN Phosphohydrolase
21 Citations (Scopus)

Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

Bai, Y., Yu, Z. H., Liu, S., Zhang, L., Zhang, R. Y., Zeng, L. F., Zhang, S. & Zhang, Z-Y., Aug 15 2016, In : Cancer Research. 76, 16, p. 4805-4815 11 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Antineoplastic Agents
Liver
Pharmaceutical Chemistry
Oncogene Proteins
2020

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K. H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., Jan 15 2020, In : EMBO Journal. 39, 2, e103637.

Research output: Contribution to journalArticle

Open Access
T-cells
T-Cell Antigen Receptor
Phosphoric Monoester Hydrolases
Tumors
Immunity
2017
14 Citations (Scopus)

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Sacchetti, C., Bai, Y., Stanford, S. M., Di Benedetto, P., Cipriani, P., Santelli, E., Piera-Velazquez, S., Chernitskiy, V., Kiosses, W. B., Ceponis, A., Kaestner, K. H., Boin, F., Jimenez, S. A., Giacomelli, R., Zhang, Z-Y. & Bottini, N., Dec 1 2017, In : Nature Communications. 8, 1, 1060.

Research output: Contribution to journalArticle

fibrosis
phosphatases
Systemic Scleroderma
Fibroblasts
Phosphoric Monoester Hydrolases
2016
5 Citations (Scopus)

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

He, R., Wang, J., Yu, Z. H., Zhang, R. Y., Liu, S., Wu, L. & Zhang, Z-Y., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9094-9106 13 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Molecular Weight
Amides
Acetic Acid
X Ray Crystallography
2017
7 Citations (Scopus)

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., Wang, Q., Shen, H., Yao, X., Zhang, Z-Y., Xue, S., Shen, L. & Cheng, J., Apr 1 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

Interferons
Macrophages
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Sumoylation
Listeriosis
2016
12 Citations (Scopus)

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen

Dutta, N. K., He, R., Pinn, M. L., He, Y., Burrows, F., Zhang, Z-Y. & Karakousis, P. C., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium tuberculosis
Tuberculosis
Virulence Factors
Pharmaceutical Preparations
2017
4 Citations (Scopus)

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H., Yoder, M., Kapur, R., Mulloy, J. C., Zhang, Z-Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
1 Citation (Scopus)

The tumor promoter-activated protein kinase Cs are a system for regulating filopodia

Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z-Y. & Boudreau, N. S., Aug 1 2017, In : Cytoskeleton. 74, 8, p. 297-314 18 p.

Research output: Contribution to journalArticle

Pseudopodia
Carcinogens
Protein Kinases
Protein Kinase C
Protein Isoforms
2016
8 Citations (Scopus)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Jun 3 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
Syk Kinase
2018
8 Citations (Scopus)

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

McQueeney, K. E., Salamoun, J. M., Burnett, J. C., Barabutis, N., Pekic, P., Lewandowski, S. L., Llaneza, D. C., Cornelison, R., Bai, Y., Zhang, Z-Y., Catravas, J. D., Landen, C. N., Wipf, P., Lazo, J. S. & Sharlow, E. R., Jan 1 2018, In : Oncotarget. 9, 9, p. 8223-8240 18 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Ovarian Neoplasms
Endothelium
Neoplasms
Pericytes
10 Citations (Scopus)

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z-Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., Sep 19 2018, In : eLife. 7

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Neuronal Plasticity
Metabolism
Plasticity
Neurons
2019

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z-Y., Gribble, G. W., Spinola, S. & Duerfeldt, A. S., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Phosphoric Monoester Hydrolases
Amines
Indoles
Scaffolds
2017
24 Citations (Scopus)

Therapeutic targeting of oncogenic tyrosine phosphatases

Frankson, R., Yu, Z. H., Bai, Y., Li, Q., Zhang, R. Y. & Zhang, Z-Y., Nov 1 2017, In : Cancer Research. 77, 21, p. 5701-5705 5 p.

Research output: Contribution to journalReview article

Phosphoric Monoester Hydrolases
Tyrosine
Protein Tyrosine Phosphatases
Neoplasms
Drug Discovery
2016

Discovery and evaluation of PRL trimer disruptors for novel anticancer agents

Bai, Y., Yu, Z. H. & Zhang, Z. Y., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1447. p. 121-138 18 p. (Methods in Molecular Biology; vol. 1447).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphoric Monoester Hydrolases
Antineoplastic Agents
Neoplasms
Therapeutics