Find Publications

Search concepts
Selected Filters
2018
31 Citations (Scopus)

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

zoledronic acid
pamidronate
Medical Oncology
Multiple Myeloma
Practice Guidelines
2017
21 Citations (Scopus)

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Adenosine Triphosphatases
zoledronic acid
Bone and Bones
Pain
2018

Supportive care in multiple myeloma

Doshi, S. M., Noff, T. T. & Roodman, G. D., Jan 1 2018, Neoplastic Diseases of the Blood. Springer International Publishing, p. 595-607 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple Myeloma
Leukemia
Thrombosis
Bone Diseases
Kidney
2 Citations (Scopus)

Osteoblast suppression in multiple myeloma bone disease

Adamik, J., Galson, D. L. & Roodman, G. D., Nov 1 2018, In : Journal of Bone Oncology. 13, p. 62-70 9 p.

Research output: Contribution to journalReview article

Bone Diseases
Osteoblasts
Multiple Myeloma
Mesenchymal Stromal Cells
Bone Marrow
2016

Developmental Aspects of Pagetic Osteoclasts

Galson, D. L., Sun, Q. & Roodman, G. D., May 9 2016, Advances in Pathobiology and Management of Paget's Disease of Bone. Elsevier Inc., p. 37-53 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoclasts
Osteitis Deformans
Osteogenesis
RANK Ligand
Phenotype
2019

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Dexamethasone
Bone Development
Osteoblasts
2018

Mechanisms of osteolytic and osteoblastic skeletal lesions

Roodman, G. D. & Guise, T., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 739-742 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone
Tumors
Cells
Neoplasms
Neoplasm Metastasis
2016
16 Citations (Scopus)

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Osteogenesis
Bone and Bones
Growth
15 Citations (Scopus)

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

Storti, P., Marchica, V., Airoldi, I., Donofrio, G., Fiorini, E., Ferri, V., Guasco, D., Todoerti, K., Silbermann, R., Anderson, J. L., Zhao, W., Agnelli, L., Bolzoni, M., Martella, E., Mancini, C., Campanini, N., Noonan, D. M., Petronini, P. G., Neri, A., Aversa, F. & 2 others, Roodman, G. D. & Giuliani, N., Jun 17 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Galectin 1
Multiple Myeloma
Growth
Small Interfering RNA
Down-Regulation
2017
22 Citations (Scopus)

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Multiple Myeloma
Epigenomics
Chromatin
Histones
24 Citations (Scopus)

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L. I., Bellido, T. & Roodman, G. D., Jan 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Pharmacology
Growth
Neoplasms
2018
2 Citations (Scopus)

Paget disease of bone

Charles, J. F., Siris, E. S. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 713-720 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteitis Deformans
Bone
Osteoclasts
Diphosphonates
Medical History Taking
2017

Vitamin D and Paget's Disease

Kurihara, N. & Roodman, G. D., Dec 14 2017, Health, Disease and Therapeutics. Elsevier Inc., Vol. 2. p. 571-579 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

osteoclasts
vitamin D
Vitamin D
Osteoclasts
Measles virus
2016
14 Citations (Scopus)

Current Controversies in the Management of Myeloma Bone Disease

Silbermann, R. & Roodman, G. D., Nov 1 2016, In : Journal of Cellular Physiology. 231, 11, p. 2374-2379 6 p.

Research output: Contribution to journalReview article

Bone Diseases
Bone
Anabolic Agents
Diphosphonates
Proteasome Endopeptidase Complex
2018

Cancer and bone

Guise, T. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 737-738 2 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Bone Neoplasms
Bone
2016
11 Citations (Scopus)

Bone disease in multiple myeloma

Eda, H., Santo, L., Roodman, G. D. & Raje, N., Jan 1 2016, Cancer Treatment and Research. Kluwer Academic Publishers, p. 251-270 20 p. (Cancer Treatment and Research; vol. 169).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Diseases
Multiple Myeloma
Osteoblasts
Osteoclasts
Bone Remodeling
15 Citations (Scopus)

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease

Teramachi, J., Nagata, Y., Mohammad, K., Inagaki, Y., Ohata, Y., Guise, T., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N. & Roodman, G. D., Mar 1 2016, In : Journal of Clinical Investigation. 126, 3, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Bone Resorption
Osteogenesis
Interleukin-6
2018

Primer on the metabolic bone diseases and disorders of mineral metabolism

Bilezikian, J. P., Bouillon, R., Clemens, T., Compston, J., Bauer, D. C., Ebeling, P. R., Engelke, K., Goltzman, D., Guise, T., Jan De Beur, S. M., Jüppner, H., Lyons, K., McCauley, L., McClung, M. R., Miller, P. D., Papapoulos, S. E., Roodman, G. D., Rosen, C. J., Seeman, E., Thakker, R. V. & 2 others, Whyte, M. P. & Zaidi, M., Jan 1 2018, wiley. 1105 p.

Research output: Book/ReportBook

Metabolic Bone Diseases
Metabolism
Minerals
Bone
Bone Diseases
2019
3 Citations (Scopus)

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journalArticle

Open Access
Kyphoplasty
Compression Fractures
Multiple Myeloma
Consensus
Pain
2016
25 Citations (Scopus)

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Matrix Metalloproteinases
Multiple Myeloma
Bone Diseases
Matrix Metalloproteinase 13
2018
4 Citations (Scopus)

Bones in Multiple Myeloma: Imaging and Therapy

Zamagni, E., Cavo, M., Fakhri, B., Vij, R. & Roodman, G. D., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 638-646 9 p.

Research output: Contribution to journalReview article

Bone Diseases
Multiple Myeloma
Disease Management
Bone and Bones
RANK Ligand
2016
31 Citations (Scopus)

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Confidence Intervals
Survival
Lost to Follow-Up
2017
61 Citations (Scopus)

Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG

Hadji, P., Aapro, M. S., Body, J. J., Gnant, M., Brandi, M. L., Reginster, J. Y., Zillikens, M. C., Glüer, C. C., de Villiers, T., Baber, R., Roodman, G. D., Cooper, C., Langdahl, B., Palacios, S., Kanis, J., Al-Daghri, N., Nogues, X., Eriksen, E. F., Kurth, A., Rizzoli, R. & 1 others, Coleman, R. E., Jun 1 2017, In : Journal of Bone Oncology. 7, p. 1-12 12 p.

Research output: Contribution to journalReview article

Aromatase Inhibitors
Postmenopausal Osteoporosis
Joints
Hormones
Breast Neoplasms
2018
3 Citations (Scopus)

Multiple myeloma and bone: The fatal interaction

Marino, S. & Roodman, G. D., Aug 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 8, a031286.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone
Bone and Bones
Bone Diseases
Spontaneous Fractures
2017
5 Citations (Scopus)

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma

Hao, M., Franqui-Machin, R., Xu, H., Shaughnessy, J., Barlogie, B., Roodman, G. D., Quelle, D. E., Janz, S., Tomasson, M. H., Sanderson, R. D., Qiu, L., Frech, I., Tricot, G. & Zhan, F., Jul 1 2017, In : Leukemia. 31, 7, p. 1648-1650 3 p.

Research output: Contribution to journalLetter

2018
1 Citation (Scopus)

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Petrusca, D., Toscani, D., Wang, F. M., Park, C., Crean, C. D., Anderson, J. L., Marino, S., Mohammad, K., Zhou, D., Silbermann, R., Sun, Q., Kurihara, N., Galson, D. L., Giuliani, N. & Roodman, G. D., Oct 4 2018, In : Journal of Hematology and Oncology. 11, 1, 123.

Research output: Contribution to journalArticle

Multiple Myeloma
Osteogenesis
Intercellular Signaling Peptides and Proteins
Survival
Growth
64 Citations (Scopus)

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: An international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Jan 1 2018, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
Therapeutics
Safety
3 Citations (Scopus)

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., Mar 6 2018, (Accepted/In press) In : Journal of Medical Economics. p. 1-12 12 p.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Cost-Benefit Analysis
Costs and Cost Analysis
Disease-Free Survival
2 Citations (Scopus)

XRK3F2 inhibition of p62-ZZ domain signaling rescues myeloma-induced GFI1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression

Adamik, J., Silbermann, R., Marino, S., Sun, Q., Anderson, J. L., Zhou, D., Xie, X. Q., Roodman, G. D. & Galson, D. L., Jun 29 2018, In : Frontiers in Endocrinology. 9, JUL, 344.

Research output: Contribution to journalArticle

Epigenetic Repression
Osteoblasts
Mesenchymal Stromal Cells
Histone Deacetylase 1
Tissue Donors
2016
64 Citations (Scopus)
Osteocytes
Tumor Microenvironment
Multiple Myeloma
Bone Marrow
Cell Proliferation
2019

Therapeutic targets in myeloma bone disease

Marino, S., Petrusca, D. N. & Roodman, G. D., Jan 1 2019, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalReview article

Bone Diseases
Multiple Myeloma
Bone Remodeling
Osteogenesis
Bone Density Conservation Agents