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2017
17 Citations (Scopus)

Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression

Kim, Y. D., Hwang, S. L., Lee, E. J., Kim, H. M., Chung, M. J., Elfadl, A. K., Lee, S. E., Nedumaran, B., Harris, R. & Jeong, K. S., Mar 1 2017, In : Journal of Pineal Research. 62, 2, e12386.

Research output: Contribution to journalArticle

Melatonin
Bile Acids and Salts
Alcohols
Yin-Yang
B-Lymphocytes
2016
15 Citations (Scopus)

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease

Hamilton, J., Pellman, J. J., Brustovetsky, T., Harris, R. & Broustovetski, N., 2016, In : Human Molecular Genetics. 25, 13, p. 2762-2775 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Mitochondria
Neurons
Brain
2018
5 Citations (Scopus)

PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

Park, B. Y., Jeon, J. H., Go, Y., Ham, H. J., Kim, J. E., Yoo, E. K., Kwon, W. H., Jeoung, N. H., Jeon, Y. H., Koo, S. H., Kim, B. G., He, L., Park, K. G., Harris, R. & Lee, I. K., Oct 1 2018, In : Diabetes. 67, 10, p. 2054-2068 15 p.

Research output: Contribution to journalArticle

Glucagon
AMP-Activated Protein Kinases
Fatty Acids
Type 4 Cyclic Nucleotide Phosphodiesterase
Adenosine Triphosphate
2016
7 Citations (Scopus)

The orphan nuclear receptor erraγ regulates hepatic cb1 receptor-mediated fibroblast growth factor 21 gene expression

Jung, Y. S., Lee, J. M., Kim, D. K., Lee, Y. S., Kim, K. S., Kim, Y. H., Kim, J., Lee, M. S., Lee, I. K., Kim, S. H., Cho, S. J., Jeong, W. I., Lee, C. H., Harris, R. & Choi, H. S., Jul 1 2016, In : PLoS One. 11, 7, e0159425.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
fibroblast growth factors
Gene expression
Estrogen Receptors
Estrogens
10 Citations (Scopus)

Insulin-Inducible SMILE inhibits hepatic gluconeogenesis

Lee, J. M., Seo, W. Y., Han, H. S., Oh, K. J., Lee, Y. S., Kim, D. K., Choi, S., Choi, B. H., Harris, R. A., Lee, C. H., Koo, S. H. & Choi, H. S., Jan 2016, In : Diabetes. 65, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Insulin
Liver
Co-Repressor Proteins
Proto-Oncogene Proteins c-akt
8 Citations (Scopus)

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A. N., Mang, H., Plotkin, Z., Dube, S., Hutchins, G. D., Territo, P. R., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R. A., Daghe, P. C. & Sutton, T. A., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

Positron-Emission Tomography
Kidney
Glucose
Glycolysis
Pharmacology
2019
4 Citations (Scopus)

PDK4 augments ER–mitochondria contact to dampen skeletal muscle insulin signaling during obesity

Thoudam, T., Ha, C. M., Leem, J., Chanda, D., Park, J. S., Kim, H. J., Jeon, J. H., Choi, Y. K., Liangpunsakul, S., Huh, Y. H., Kwon, T. H., Park, K. G., Harris, R., Park, K. S., Rhee, H. W. & Lee, I. K., Mar 1 2019, In : Diabetes. 68, 3, p. 571-586 16 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Skeletal Muscle
Obesity
Insulin
3 Citations (Scopus)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Min, B. K., Park, S., Kang, H. J., Kim, D. W., Ham, H. J., Ha, C. M., Choi, B. J., Lee, J. Y., Oh, C. J., Yoo, E. K., Kim, H. E., Kim, B. G., Jeon, J. H., Hyeon, D. Y., Hwang, D., Kim, Y. H., Lee, C. H., Lee, T., Kim, J. W., Choi, Y. K. & 5 others, Park, K. G., Chawla, A., Lee, J., Harris, R. & Lee, I. K., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Macrophages
Phenotype
Pyruvic Acid
Insulin Resistance
Obesity
2018

The SMILE transcriptional corepressor inhibits cAMP response element– binding protein (CREB)–mediated transactivation of gluconeogenic genes

Lee, J. M., Han, H. S., Jung, Y. S., Harris, R., Koo, S. H. & Choi, H. S., Jan 1 2018, In : Journal of Biological Chemistry. 293, 34, p. 13125-13133 9 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Co-Repressor Proteins
Transcription
Transcriptional Activation
Genes
6 Citations (Scopus)

E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells

Xu, S., Tao, J., Yang, L., Zhang, E., Boriboun, C., Zhou, J., Sun, T., Cheng, M., Huang, K., Shi, J., Dong, N., Liu, Q., Zhao, T. C., Qiu, H., Harris, R. A., Chandel, N. S., Losordo, D. W. & Qin, G., Mar 2018, In : Circulation research. 122, 5, p. 701-711 11 p.

Research output: Contribution to journalArticle

E2F1 Transcription Factor
Bone Marrow Cells
Stem Cells
Cell- and Tissue-Based Therapy
Endothelial Cells
1 Citation (Scopus)

Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate

Noguchi, S., Kondo, Y., Ito, R., Katayama, T., Kazama, S., Kadota, Y., Kitaura, Y., Harris, R. & Shimomura, Y., Oct 12 2018, In : Biochemical and Biophysical Research Communications. 504, 4, p. 916-920 5 p.

Research output: Contribution to journalArticle

thiamin-diphosphate kinase
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Thiamine Pyrophosphate
Phosphotransferases
Branched Chain Amino Acids
2016
18 Citations (Scopus)

Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy

Rahman, M. H., Jha, M. K., Kim, J. H., Nam, Y., Lee, M. G., Go, Y., Harris, R., Park, D. H., Kook, H., Lee, I. K. & Suk, K., Mar 11 2016, In : Journal of Biological Chemistry. 291, 11, p. 6011-6025 15 p.

Research output: Contribution to journalArticle

Diabetic Neuropathies
Spinal Ganglia
Medical problems
Lactic Acid
Ion Channels
2019

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., Hirschey, M. D. & 1 others, Cohen, H. Y., Dec 17 2019, In : Cell Reports. 29, 12, p. 4127-4143.e8

Research output: Contribution to journalArticle

Open Access
Peroxisome Proliferator-Activated Receptors
Metabolic Networks and Pathways
Pyruvic Acid
Fasting
Fatty Acids
2016
20 Citations (Scopus)

Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis

Jang, J. E., Ko, M. S., Yun, J. Y., Kim, M. O., Kim, J. H., Park, H. S., Kim, A. R., Kim, H. J., Kim, B. J., Ahn, Y. E., Oh, J. S., Lee, W. J., Harris, R., Koh, E. H. & Lee, K. U., Sep 1 2016, In : Diabetes. 65, 9, p. 2516-2528 13 p.

Research output: Contribution to journalArticle

Adipocytes
Adipose Tissue
Nitric Oxide
Fibrosis
Macrophages
2019
2 Citations (Scopus)

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Pin, F., Novinger, L. J., Huot, J. R., Harris, R., Couch, M. E., O'Connell, T. M. & Bonetto, A., Jun 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 7778-7790 13 p.

Research output: Contribution to journalArticle

Cachexia
Muscular Atrophy
Muscle
Skeletal Muscle Fibers
Neoplasms
2016

Erratum: Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation (Scientific Reports 5:16577; DOI:10.1038/srep16577)

Lee, S. J., Jeong, J. Y., Oh, C. J., Park, S., Kim, J. Y., Kim, H. J., Kim, N. D., Choi, Y. K., Do, J. Y., Go, Y., Ha, C. M., Choi, J. Y., Huh, S., Jeoung, N. H., Lee, K. U., Choi, H. S., Wang, Y., Park, K. G., Harris, R. A. & Lee, I. K., Jan 27 2016, In : Scientific Reports. 6, 18552.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiong, X., Wang, G., Tao, R., Wu, P., Kono, T., Li, K., Ding, W. X., Tong, X., Tersey, S. A., Harris, R., Mirmira, R., Evans-Molina, C. & Dong, X., Jan 1 2016, In : Diabetologia. 59, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

Insulin-Secreting Cells
Insulin
Glucose
Knockout Mice
Oxygen Consumption
24 Citations (Scopus)

Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury

Oh, C. J., Ha, C. M., Choi, Y. K., Park, S., Choe, M. S., Jeoung, N. H., Huh, Y. H., Kim, H. J., Kweon, H. S., Lee, J. M., Lee, S. J., Jeon, J. H., Harris, R., Park, K. G. & Lee, I. K., Feb 2 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cisplatin
Knockout Mice
Kidney
Dichloroacetic Acid
15 Citations (Scopus)

Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis

Go, Y., Jeong, J. Y., Jeoung, N. H., Jeon, J. H., Park, B. Y., Kang, H. J., Ha, C. M., Choi, Y. K., Lee, S. J., Ham, H. J., Kim, B. G., Park, K. G., Park, S. Y., Lee, C. H., Choi, C. S., Park, T. S., Paul Lee, W. N., Harris, R. & Lee, I. K., Oct 1 2016, In : Diabetes. 65, 10, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

Citric Acid Cycle
Pyruvate Dehydrogenase Complex
Liver
Insulin Resistance
Tricarboxylic Acids
7 Citations (Scopus)

O-GlcNAcylation of orphan nuclear receptor estrogen-related receptorγ promotes hepatic gluconeogenesis

Misra, J., Kim, D. K., Jung, Y. S., Kim, H. B., Kim, Y. H., Yoo, E. K., Kim, B. G., Kim, S., Lee, I. K., Harris, R., Kim, J. S., Lee, C. H., Cho, J. W. & Choi, H. S., Oct 1 2016, In : Diabetes. 65, 10, p. 2835-2848 14 p.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
Gluconeogenesis
Estrogen Receptors
Liver
Hexosamines