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  • Andrew Saykin

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In : JAMA Neurology. 75, 8, p. 989-998 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Dec 1 2018, In : Acta Neuropathologica. 136, 6, p. 857-872 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
7 Scopus citations

Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype

for the Thinking and Living With Cancer Study, Dec 15 2019, In : Cancer. 125, 24, p. 4516-4524 9 p.

Research output: Contribution to journalArticle

Sparse Canonical Correlation Analysis via truncated ℓ1-norm with application to brain imaging genetics

Du, L., Zhang, T., Liu, K., Yao, X., Yan, J., Risacher, S. L., Guo, L., Saykin, A. & Shen, L., Jan 17 2017, Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016. Institute of Electrical and Electronics Engineers Inc., p. 707-711 5 p. 7822605

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

Gordon, B. A., Blazey, T. M., Su, Y., Hari-Raj, A., Dincer, A., Flores, S., Christensen, J., McDade, E., Wang, G., Xiong, C., Cairns, N. J., Hassenstab, J., Marcus, D. S., Fagan, A. M., Jack, C. R., Hornbeck, R. C., Paumier, K. L., Ances, B. M., Berman, S. B., Brickman, A. M. & 20 others, Cash, D. M., Chhatwal, J. P., Correia, S., Förster, S., Fox, N. C., Graff-Radford, N. R., la Fougère, C., Levin, J., Masters, C. L., Rossor, M. N., Salloway, S., Saykin, A. J., Schofield, P. R., Thompson, P. M., Weiner, M. M., Holtzman, D. M., Raichle, M. E., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Mar 2018, In : The Lancet Neurology. 17, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Stability of MRI metrics in the advanced research core of the NCAA-DoD concussion assessment, research and education (CARE) consortium

Nencka, A. S., Meier, T. B., Wang, Y., Muftuler, L. T., Wu, Y. C., Saykin, A. J., Harezlak, J., Brooks, M. A., Giza, C. C., Difiori, J., Guskiewicz, K. M., Mihalik, J. P., LaConte, S. M., Duma, S. M., Broglio, S., McAllister, T., McCrea, M. A. & Koch, K. M., Aug 1 2018, In : Brain Imaging and Behavior. 12, 4, p. 1121-1140 20 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structured sparse canonical correlation analysis for brain imaging genetics: An improved GraphNet method

Du, L., Huang, H., Yan, J., Kim, S., Risacher, S. L., Inlow, M., Moore, J. H., Saykin, A. J. & Shen, L., May 15 2016, In : Bioinformatics. 32, 10, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Structured sparse CCA for brain imaging genetics via graph OSCAR

Du, L., Huang, H., Yan, J., Kim, S., Risacher, S., Inlow, M., Moore, J., Saykin, A. & Shen, L., Aug 26 2016, In : BMC Systems Biology. 10, 68.

Research output: Contribution to journalArticle

6 Scopus citations

Subcortical brain iron deposition and cognitive performance in older women with breast cancer receiving adjuvant chemotherapy: A pilot MRI study

Chen, B. T., Ghassaban, K., Jin, T., Patel, S. K., Ye, N., Sun, C. L., Kim, H., Rockne, R. C., Mark Haacke, E., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Prakash, N., Mortimer, J., Waisman, J., Yuan, Y., Somlo, G., Li, D., Yang, R. & 4 others, Tan, H., Katheria, V., Morrison, R. & Hurria, A., Dec 2018, In : Magnetic Resonance Imaging. 54, p. 218-224 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group & SCD-I working group, Mar 2019, In : Alzheimer's and Dementia. 15, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Targeted genetic analysis of cerebral blood flow imaging phenotypes implicates the INPP5D gene

Alzheimer's Disease Neuroimaging Initiative, Sep 2019, In : Neurobiology of Aging. 81, p. 213-221 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

St John-Williams, L., Blach, C., Toledo, J. B., Rotroff, D. M., Kim, S., Klavins, K., Baillie, R., Han, X., Mahmoudiandehkordi, S., Jack, J., Massaro, T. J., Lucas, J. E., Louie, G., Motsinger-Reif, A. A., Risacher, S. L., Saykin, A. J., Kastenmüller, G., Arnold, M., Koal, T., Moseley, M. A. & 5 others, Mangravite, L. M., Peters, M. A., Tenenbaum, J. D., Thompson, J. W. & Kaddurah-Daouk, R., Oct 17 2017, In : Scientific Data. 4, 170140.

Research output: Contribution to journalArticle

18 Scopus citations

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative (ADNI), Dec 2017, In : Neurobiology of Aging. 60, p. 92-103 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Task-evoked functional connectivity does not explain functional connectivity differences between rest and task conditions

Lynch, L. K., Lu, K. H., Wen, H., Zhang, Y., Saykin, A. J. & Liu, Z., Dec 2018, In : Human Brain Mapping. 39, 12, p. 4939-4948 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Telomere length associations with cognition depend on Alzheimer's disease biomarkers

Alzheimer's Disease Neuroimaging Initiative, 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 883-890 8 p.

Research output: Contribution to journalArticle

Open Access

Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort

Nudelman, K. N. H., Lin, J., Lane, K. A., Nho, K., Kim, S., Faber, K. M., Risacher, S. L., Foroud, T. M., Gao, S., Davis, J. W., Weiner, M. W. & Saykin, A. J., Jan 1 2019, In : Journal of Alzheimer's Disease. 71, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

Alzheimer's Disease Neuroimaging Initiative, May 2017, In : Alzheimer's and Dementia. 13, 5, p. 561-571 11 p.

Research output: Contribution to journalReview article

46 Scopus citations

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Nature communications. 10, 1, 1766.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The cognitive change index as a measure of self and informant perception of cognitive decline: Relation to neuropsychological tests

Rattanabannakit, C., Risacher, S. L., Gao, S., Lane, K. A., Brown, S. A., McDonald, B. C., Unverzagt, F. W., Apostolova, L. G., Saykin, A. J. & Farlow, M. R., Apr 12 2016, In : Journal of Alzheimer's Disease. 51, 4, p. 1145-1155 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism

Stage, E., Duran, T., Risacher, S. L., Goukasian, N., Do, T. M., West, J. D., Wilhalme, H., Nho, K., Phillips, M., Elashoff, D., Saykin, A. J. & Apostolova, L. G., Jan 1 2016, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 5, p. 53-66 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The executive prominent/memory prominent spectrum in Alzheimer's disease are highly heritable

Alzheimer's Disease Neuroimaging Initiative (ADNI1), Alzheimer's Disease Genetics Consortium (ADGC) & Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF), May 1 2016, In : Neurobiology of Aging. 41, p. 115-121 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Impact of Using Different Reference Populations on Measurement of Breast Cancer-Related Cognitive Impairment Rates

Thinking and Living with Cancer (TLC) Study, Nov 24 2017, In : Archives of Clinical Neuropsychology. 33, 8, p. 956-963 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The open diffusion data derivatives, brain data upcycling via integrated publishing of derivatives and reproducible open cloud services

Avesani, P., McPherson, B., Hayashi, S., Caiafa, C. F., Henschel, R., Garyfallidis, E., Kitchell, L., Bullock, D., Patterson, A., Olivetti, E., Sporns, O., Saykin, A. J., Wang, L., Dinov, I., Hancock, D., Caron, B., Qian, Y. & Pestilli, F., Dec 1 2019, In : Scientific Data. 6, 1, 69.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The Vascular Impairment of Cognition Classification Consensus Study

VICCCS group, Jun 2017, In : Alzheimer's and Dementia. 13, 6, p. 624-633 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tissue-specific network-based genome wide study of amygdala imaging phenotypes to identify functional interaction modules

Alzheimer's Disease Neuroimaging Initiative, Oct 15 2017, In : Bioinformatics. 33, 20, p. 3250-3257 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Topographic staging of tau positron emission tomography images

Alzheimer's Disease Neuroimaging Initiative, Jan 1 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 221-231 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Towards subject and diagnostic identifiability in the alzheimer’s disease spectrum based on functional connectomes

Svaldi, D. O., Goñi, J., Bharthur Sanjay, A., Amico, E., Risacher, S. L., West, J. D., Dzemidzic, M., Saykin, A. & Apostolova, L., Jan 1 2018, Graphs in Biomedical Image Analysis and Integrating Medical Imaging and Non-Imaging Modalities - 2nd International Workshop, GRAIL 2018 and 1st International Workshop, Beyond MIC 2018 Held in Conjunction with MICCAI 2018, Proceedings. Stoyanov, D., Sotiras, A., Papiez, B., Dalca, A. V., Martel, A., Parisot, S., Ferrante, E., Maier-Hein, L., Sabuncu, M. R., Shen, L. & Taylor, Z. (eds.). Springer Verlag, p. 74-82 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11044 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Transcriptome-guided imaging genetic analysis via a novel sparse CCA algorithm

Alzheimer’s Disease Neuroimaging Initiative, 2017, Graphs in Biomedical Image Analysis, Computational Anatomy and Imaging Genetics - 1st International Workshop, GRAIL 2017 6th International Workshop, MFCA 2017 and 3rd International Workshop, MICGen 2017 Held in Conjunction with MICCAI 2017, Proceedings. Springer Verlag, Vol. 10551 LNCS. p. 220-229 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10551 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Alzheimer's Disease Genetics Consortium, Jul 2017, In : Alzheimer's and Dementia. 13, 7, p. 727-738 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Traumatic brain injury and age at onset of cognitive impairment in older adults

Li, W., Risacher, S. L., McAllister, T. W. & Saykin, A., Mar 23 2016, (Accepted/In press) In : Journal of Neurology. p. 1-6 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Two-dimensional enrichment analysis for mining high-level imaging genetic associations

Yao, X., Yan, J., Kim, S., Nho, K., Risacher, S. L., Inlow, M., Moore, J. H., Saykin, A. J. & Shen, L., Mar 1 2017, In : Brain Informatics. 4, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Type 2 diabetes mellitus, brain atrophy, and cognitive decline

Moran, C., Beare, R., Wang, W., Callisaya, M., Srikanth, V., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Liu, E., Montine, T., Gamst, A., Thomas, R. G. & 234 others, Donohue, M., Walter, S., Gessert, D., Sather, T., Harvey, D., Kornak, J., Dale, A., Bernstein, M., Felmlee, J., Fox, N., Thompson, P., Schuff, N., Alexander, G., Decarli, C., Bandy, D., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Cairns, N. J., Taylor-Reinwald, L., Trojanowki, J. Q., Shaw, L., Lee, V. M. Y., Korecka, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Kachaturian, Z., Frank, R., Snyder, P. J., Molchan, S., Kaye, J., Quinn, J., Lind, B., Dolen, S., Schneider, L. S., Pawluczyk, S., Spann, B. M., Brewer, J., Vanderswag, H., Heidebrink, J. L., Lord, J. L., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Stern, Y., Honig, L. S., Bell, K. L., Morris, J. C., Ances, B., Carroll, M., Leon, S., Mintun, M. A., Schneider, S., Marson, D., Griffith, R., Clark, D., Grossman, H., Mitsis, E., Romirowsky, A., Detoledo-Morrell, L., Shah, R. C., Duara, R., Varon, D., Roberts, P., Albert, M., Onyike, C., Kielb, S., Rusinek, H., De Leon, M. J., Glodzik, L., De Santi, S., Doraiswamy, P. M., Petrella, J. R., Coleman, R. E., Arnold, S. E., Karlawish, J. H., Wolk, D., Smith, C. D., Jicha, G., Hardy, P., Lopez, O. L., Oakley, M., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Mulnard, R. A., Thai, G., McAdams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Diaz-Arrastia, R., King, R., Weiner, M., Martin-Cook, K., Devous, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Anderson, H. S., Swerdlow, R. H., Apostolova, L., Lu, P. H., Bartzokis, G., Silverman, D. H. S., Graff-Radford, N. R., Parfitt, F., Johnson, H., Farlow, M. R., Hake, A. M., Matthews, B. R., Herring, S., Van Dyck, C. H., Carson, R. E., Macavoy, M. G., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Kertesz, A., Rogers, J., Trost, D., Bernick, C., Munic, D., Kerwin, D., Mesulam, M. M., Lipowski, K., Wu, C. K., Johnson, N., Sadowsky, C., Martinez, W., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Frey, M., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Obisesan, T. O., Wolday, S., Bwayo, S. K., Lerner, A., Hudson, L., Ogrocki, P., Fletcher, E., Carmichael, O., Olichney, J., Kittur, S., Borrie, M., Bartha, D. R., Johnson, S., Asthana, S., Carlsson, C. M., Potkin, S. G., Preda, A., Nguyen, D., Tariot, P., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Santulli, R. B., Schwartz, E. S., Sink, K. M., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Mintzer, J., Longmire, C. F., Spicer, K., Finger, E., Rachinsky, I., Drost, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Boles Ponto, L. L., Shim, H., Smith, K. E., Relkin, N., Chaing, G., Raudin, L., Smith, A., Fargher, K. & Raj, B. A., Feb 19 2019, In : Neurology. 92, 8, p. E823-E830

Research output: Contribution to journalArticle

10 Scopus citations
15 Scopus citations

Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort

Li, W., Risacher, S. L., Huang, E. & Saykin, A., Aug 9 2016, In : Neurology. 87, 6, p. 595-600 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

The Genetic FTD Initiative (GENFI) & The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2018, In : Nature communications. 9, 1, 4273.

Research output: Contribution to journalArticle

25 Scopus citations

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's Disease Neuroimaging Initiative, Jan 2019, In : Alzheimer's and Dementia. 15, 1, p. 106-152 47 p.

Research output: Contribution to journalReview article

31 Scopus citations

Unified representation of tractography and diffusion-weighted MRI data using sparse multidimensional arrays

Caiafa, C. F., Sporns, O., Saykin, A. & Pestilli, F., Jan 1 2017, In : Advances in Neural Information Processing Systems. 2017-December, p. 4341-4352 12 p.

Research output: Contribution to journalConference article

4 Scopus citations

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

Dominantly Inherited Alzheimer Network, Jan 1 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 669-677 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

for the Alzheimer's Disease Neuroimaging Initiative, Jun 29 2016, In : BMC genomics. 17, 439.

Research output: Contribution to journalArticle

1 Scopus citations

Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

for the Alzheimer's Disease Neuroimaging Initiative, Jun 29 2016, In : BMC genomics. 17, 437.

Research output: Contribution to journalArticle

1 Scopus citations

Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans

Cong, S., Risacher, S. L., West, J. D., Wu, Y. C., Apostolova, L. G., Tallman, E., Rizkalla, M., Salama, P., Saykin, A. J. & Shen, L., Dec 1 2018, In : Brain Imaging and Behavior. 12, 6, p. 1583-1595 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

White matter alterations in early-stage Alzheimer's disease: A tract-specific study

Wen, Q., Mustafi, S. M., Li, J., Risacher, S. L., Tallman, E., Brown, S. A., West, J. D., Harezlak, J., Farlow, M. R., Unverzagt, F. W., Gao, S., Apostolova, L. G., Saykin, A. J. & Wu, Y. C., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 576-587 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease

Lee, S., Zimmerman, M. E., Narkhede, A., Nasrabady, S. E., Tosto, G., Meier, I. B., Benzinger, T. L. S., Marcus, D. S., Fagan, A. M., Fox, N. C., Cairns, N. J., Holtzman, D. M., Buckles, V., Ghetti, B., McDade, E., Martins, R. N., Saykin, A. J., Masters, C. L., Ringman, J. M., Fӧrster, S. & 12 others, Schofield, P. R., Sperling, R. A., Johnson, K. A., Chhatwal, J. P., Salloway, S., Correia, S., Jack, C. R., Weiner, M., Bateman, R. J., Morris, J. C., Mayeux, R. & Brickman, A. M., May 2018, In : PloS one. 13, 5, e0195838.

Research output: Contribution to journalArticle

10 Scopus citations

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

Lee, S., Viqar, F., Zimmerman, M. E., Narkhede, A., Tosto, G., Benzinger, T. L. S., Marcus, D. S., Fagan, A. M., Goate, A., Fox, N. C., Cairns, N. J., Holtzman, D. M., Buckles, V., Ghetti, B., McDade, E., Martins, R. N., Saykin, A. J., Masters, C. L., Ringman, J. M., Ryan, N. S. & 12 others, Förster, S., Laske, C., Schofield, P. R., Sperling, R. A., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R. J., Morris, J. C., Mayeux, R. & Brickman, A. M., Jun 1 2016, In : Annals of neurology. 79, 6, p. 929-939 11 p.

Research output: Contribution to journalArticle

118 Scopus citations