Find Publications

Search in all content

Filters for Publications

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Li Shen
2016

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

Alzheimer's Disease Neuroimaging Initiative, Jun 2016, In : JAMA Neurology. 73, 6, p. 721-732 12 p.

Research output: Contribution to journalArticle

107 Scopus citations

Building a surface atlas of hippocampal subfields from high resolution T2-weighted MRI scans using landmark-free surface registration

Cong, S., Rizkalla, M., Salama, P., Risacher, S. L., West, J. D., Wu, Y. C., Apostolova, L., Tallman, E., Saykin, A. J. & Shen, L., Jul 2 2016, 2016 IEEE 59th International Midwest Symposium on Circuits and Systems, MWSCAS 2016. Institute of Electrical and Electronics Engineers Inc., 7870109. (Midwest Symposium on Circuits and Systems; vol. 0).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Diagnosis-guided method for identifying multi-modality neuroimaging biomarkers associated with genetic risk factors in Alzheimer’s disease

Hao, X., Yan, J., Yao, X., Risacher, S. L., Saykin, A. J., Zhang, D. & Shen, L., Jan 1 2016, In : Pacific Symposium on Biocomputing. p. 108-119 12 p.

Research output: Contribution to journalConference article

3 Scopus citations

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

The Alzheimer's Disease Neuroimaging Initiative, Jun 21 2016, In : Nature communications. 7, 11934.

Research output: Contribution to journalArticle

301 Scopus citations

Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept

Psychosis Endophenotypes International Consortium, Feb 23 2016, In : Nature Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to journalArticle

118 Scopus citations

Identifying Multimodal Intermediate Phenotypes Between Genetic Risk Factors and Disease Status in Alzheimer’s Disease

Hao, X., Yao, X., Yan, J., Risacher, S. L., Saykin, A. J., Zhang, D., Shen, L. & for the Alzheimer’s Disease Neuroimaging Initiative, T. A. D. N. I., Oct 1 2016, In : Neuroinformatics. 14, 4, p. 439-452 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identifying significant gene-environment interactions using a combination of screening testing and hierarchical false discovery rate control

The Alzheimer's Disease Neuroimaging Initiative, Nov 1 2016, In : Genetic epidemiology. 40, 7, p. 544-557 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Machine learning in brain imaging genomics

Yan, J., Du, L., Yao, X. & Shen, L., Aug 9 2016, Machine Learning and Medical Imaging. Elsevier Inc., p. 411-434 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer's disease: A study of ADNI cohorts

Song, A., Yan, J., Kim, S., Risacher, S. L., Wong, A. K., Saykin, A. J., Shen, L. & Greene, C. S., Jan 19 2016, In : BioData Mining. 9, 1, 3.

Research output: Contribution to journalArticle

15 Scopus citations

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams, H. H. H., Hibar, D. P., Chouraki, V., Stein, J. L., Nyquist, P. A., Rentería, M. E., Trompet, S., Arias-Vasquez, A., Seshadri, S., Desrivières, S., Beecham, A. H., Jahanshad, N., Wittfeld, K., Van Der Lee, S. J., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S. & 322 others, Armstrong, N. J., Athanasiu, L., Axelsson, T., Beiser, A., Bernard, M., Bis, J. C., Blanken, L. M. E., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chauhan, G., Chen, Q., Ching, C. R. K., Cuellar-Partida, G., Braber, A. D., Doan, N. T., Ehrlich, S., Filippi, I., Ge, T., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Greven, C. U., Grimm, O., Griswold, M. E., Guadalupe, T., Hass, J., Haukvik, U. K., Hilal, S., Hofer, E., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liao, J., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A., Matarin, M., Mather, K. A., Mattheisen, M., Mazoyer, B., McKay, D. R., McWhirter, R., Milaneschi, Y., Mirza-Schreiber, N., Muetzel, R. L., Maniega, S. M., Nho, K., Nugent, A. C., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pappa, I., Pirpamer, L., Pudas, S., Pütz, B., Rajan, K. B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Thomson, R., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Vaidya, D., Van Der Grond, J., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Woldehawariat, G., Wolf, C., Wolfers, T., Xu, B., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Aggarwal, N. T., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Chen, C., Cheng, C. Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Delanty, N., Depondt, C., Destefano, A. L., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Erk, S., Espeseth, T., Evans, D. A., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Grabe, H. J., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B. C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J. J., Pol, H. E. H., Ikeda, M., Ikram, M. K., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Longstreth, W. T., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J. L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, K. L., McMahon, F. J., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schofield, P. R., Sigurdsson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Srikanth, V., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Tiemeier, H., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van Der Brug, M., Van Der Lugt, A., Van Der Wee, N. J. A., Van Duijn, C. M., Van Haren, N. E. M., Van't Ent, D., Van Tol, M. J., Vardarajan, B. N., Veltman, D. J., Vernooij, M. W., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, H. R., Zonderman, A. B., Deary, I. J., Decarli, C., Schmidt, H., Martin, N. G., De Craen, A. J. M., Wright, M. J., Launer, L. J., Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S. E., Ikram, M. A. & Thompson, P. M., Dec 1 2016, In : Nature Neuroscience. 19, 12, p. 1569-1582 14 p.

Research output: Contribution to journalArticle

93 Scopus citations

Structured sparse canonical correlation analysis for brain imaging genetics: An improved GraphNet method

Du, L., Huang, H., Yan, J., Kim, S., Risacher, S. L., Inlow, M., Moore, J. H., Saykin, A. J. & Shen, L., May 15 2016, In : Bioinformatics. 32, 10, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structured sparse CCA for brain imaging genetics via graph OSCAR

Du, L., Huang, H., Yan, J., Kim, S., Risacher, S., Inlow, M., Moore, J., Saykin, A. & Shen, L., Aug 26 2016, In : BMC Systems Biology. 10, 68.

Research output: Contribution to journalArticle

7 Scopus citations
2015

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Alzheimer's Disease Neuroimaging Initiative, Jun 1 2015, In : Alzheimer's and Dementia. 11, 6, p. e1-e120

Research output: Contribution to journalArticle

154 Scopus citations

A Mixture Dose-Response Model for Identifying High-Dimensional Drug Interaction Effects on Myopathy Using Electronic Medical Record Databases

Zhang, P., Du, L., Wang, L., Liu, M., Cheng, L., Chiang, C. W., Wu, H. Y., Quinney, S. K., Shen, L. & Li, L., Aug 1 2015, In : CPT: Pharmacometrics and Systems Pharmacology. 4, 8, p. 474-480 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

Risacher, S. L., Kim, S., Nho, K., Foroud, T., Shen, L., Petersen, R. C., Jack, C. R., Beckett, L. A., Aisen, P. S., Koeppe, R. A., Jagust, W. J., Shaw, L. M., Trojanowski, J. Q., Weiner, M. W., Saykin, A. J. & Alzheimer's Disease Neuroimaging Initiative (ADNI), D. N. I. ADNI., Dec 1 2015, In : Alzheimer's and Dementia. 11, 12, p. 1417-1429 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Common genetic variants influence human subcortical brain structures

Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Boks, M. P., Bralten, J., Brown, A. A., Mallar Chakravarty, M., Chen, Q., Ching, C. R. K. & 267 others, Cuellar-Partida, G., Den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Olde Loohuis, L. M., Luciano, M., MacAre, C., Mather, K. A., Mattheisen, M., Milaneschi, Y., Nho, K., Papmeyer, M., Ramasamy, A., Risacher, S. L., Roiz-Santiañez, R., Rose, E. J., Salami, A., Sämann, P. G., Schmaal, L., Schork, A. J., Shin, J., Strike, L. T., Teumer, A., Van Donkelaar, M. M. J., Van Eijk, K. R., Walters, R. K., Westlye, L. T., Whelan, C. D., Winkler, A. M., Zwiers, M. P., Alhusaini, S., Athanasiu, L., Ehrlich, S., Hakobjan, M. M. H., Hartberg, C. B., Haukvik, U. K., Heister, A. J. G. A. M., Hoehn, D., Kasperaviciute, D., Liewald, D. C. M., Lopez, L. M., Makkinje, R. R. R., Matarin, M., Naber, M. A. M., Reese McKay, D., Needham, M., Nugent, A. C., Pütz, B., Royle, N. A., Shen, L., Sprooten, E., Trabzuni, D., Van Der Marel, S. S. L., Van Hulzen, K. J. E., Walton, E., Wolf, C., Almasy, L., Ames, D., Arepalli, S., Assareh, A. A., Bastin, M. E., Brodaty, H., Bulayeva, K. B., Carless, M. A., Cichon, S., Corvin, A., Curran, J. E., Czisch, M., De Zubicaray, G. I., Dillman, A., Duggirala, R., Dyer, T. D., Erk, S., Fedko, I. O., Ferrucci, L., Foroud, T. M., Fox, P. T., Fukunaga, M., Raphael Gibbs, J., Göring, H. H. H., Green, R. C., Guelfi, S., Hansell, N. K., Hartman, C. A., Hegenscheid, K., Heinz, A., Hernandez, D. G., Heslenfeld, D. J., Hoekstra, P. J., Holsboer, F., Homuth, G., Hottenga, J. J., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Kanai, R., Keil, M., Kent, J. W., Kochunov, P., Kwok, J. B., Lawrie, S. M., Liu, X., Longo, D. L., McMahon, K. L., Meisenzahl, E., Melle, I., Mohnke, S., Montgomery, G. W., Mostert, J. C., Mühleisen, T. W., Nalls, M. A., Nichols, T. E., Nilsson, L. G., Nöthen, M. M., Ohi, K., Olvera, R. L., Perez-Iglesias, R., Bruce Pike, G., Potkin, S. G., Reinvang, I., Reppermund, S., Rietschel, M., Romanczuk-Seiferth, N., Rosen, G. D., Rujescu, D., Schnell, K., Schofield, P. R., Smith, C., Steen, V. M., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Valdés Hernández, M. C., Van 'T Ent, D., Van Der Brug, M., Van Der Wee, N. J. A., Van Tol, M. J., Veltman, D. J., Wassink, T. H., Westman, E., Zielke, R. H., Zonderman, A. B., Ashbrook, D. G., Hager, R., Lu, L., McMahon, F. J., Morris, D. W., Williams, R. W., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Cahn, W., Calhoun, V. D., Cavalleri, G. L., Crespo-Facorro, B., Dale, A. M., Davies, G. E., Delanty, N., Depondt, C., Djurovic, S., Drevets, W. C., Espeseth, T., Gollub, R. L., Ho, B. C., Hoffmann, W., Hosten, N., Kahn, R. S., Le Hellard, S., Meyer-Lindenberg, A., Müller-Myhsok, B., Nauck, M., Nyberg, L., Pandolfo, M., Penninx, B. W. J. H., Roffman, J. L., Sisodiya, S. M., Smoller, J. W., Van Bokhoven, H., Van Haren, N. E. M., Völzke, H., Walter, H., Weiner, M. W., Wen, W., White, T., Agartz, I., Andreassen, O. A., Blangero, J., Boomsma, D. I., Brouwer, R. M., Cannon, D. M., Cookson, M. R., De Geus, E. J. C., Deary, I. J., Donohoe, G., Fernández, G., Fisher, S. E., Francks, C., Glahn, D. C., Grabe, H. J., Gruber, O., Hardy, J., Hashimoto, R., Hulshoff Pol, H. E., Jönsson, E. G., Kloszewska, I., Lovestone, S., Mattay, V. S., Mecocci, P., McDonald, C., McIntosh, A. M., Ophoff, R. A., Paus, T., Pausova, Z., Ryten, M., Sachdev, P. S., Saykin, A. J., Simmons, A., Singleton, A., Soininen, H., Wardlaw, J. M., Weale, M. E., Weinberger, D. R., Adams, H. H. H., Launer, L. J., Seiler, S., Schmidt, R., Chauhan, G., Satizabal, C. L., Becker, J. T., Yanek, L., Van Der Lee, S. J., Ebling, M., Fischl, B., Longstreth, W. T., Greve, D., Schmidt, H., Nyquist, P., Vinke, L. N., Van Duijn, C. M., Xue, L., Mazoyer, B., Bis, J. C., Gudnason, V., Seshadri, S., Ikram, M. A., Martin, N. G., Wright, M. J., Schumann, G., Franke, B., Thompson, P. M. & Medland, S. E., Apr 9 2015, In : Nature. 520, 7546, p. 224-229 6 p.

Research output: Contribution to journalArticle

416 Scopus citations

Computed tomography assessment of peripubertal craniofacial morphology in a sheep model of binge alcohol drinking in the first trimester

Birch, S. M., Lenox, M. W., Kornegay, J. N., Shen, L., Ai, H., Ren, X., Goodlett, C. R., Cudd, T. A. & Washburn, S. E., Mar 2 2015, In : Alcohol. 49, 7, p. 675-689 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cortical surface biomarkers for predicting cognitive outcomes using group l2,1 norm

Alzheimer's Disease Neuroimaging Initiative, Jan 1 2015, In : Neurobiology of Aging. 36, S1, p. S185-S193

Research output: Contribution to journalArticle

25 Scopus citations

Erratum to: A new hydropathy scale that improves disorder prediction, [BMC Bioinformatics, 15(Suppl 17) (2014), 54]

Huang, F., Oldfield, C. J., Xue, B., Hsu, W. L., Meng, J., Liu, X., Shen, L., Romero, P., Uversky, V. N. & Dunker, A. K., Jul 31 2015, In : BMC bioinformatics. 16, 1, 241.

Research output: Contribution to journalComment/debate

FASTKD2 is associated with memory and hippocampal structure in older adults

Ramanan, V. K., Nho, K., Shen, L., Risacher, S. L., Kim, S., McDonald, B. C., Farlow, M. R., Foroud, T. M., Gao, S., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Aisen, P. S., Petersen, R. C., Jack, C. R., Shaw, L. M., Trojanowski, J. Q. & 7 others, Weiner, M. W., Green, R. C., Toga, A. W., De Jager, P. L., Yu, L., Bennett, D. A. & Saykin, A. J., Oct 29 2015, In : Molecular Psychiatry. 20, 10, p. 1197-1204 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Alzheimer's Disease Neuroimaging Initiative, May 19 2015, In : Nature communications. 6, 6760.

Research output: Contribution to journalArticle

118 Scopus citations

Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort

Li, J., Zhang, Q., Chen, F., Yan, J., Kim, S., Wang, L., Feng, W., Saykin, A. J., Liang, H. & Shen, L., 2015, In : BioMed research international. 2015, 647389.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

Saykin, A. J., Shen, L., Yao, X., Kim, S., Nho, K., Risacher, S. L., Ramanan, V. K., Foroud, T. M., Faber, K. M., Sarwar, N., Munsie, L. M., Hu, X., Soares, H. D., Potkin, S. G., Thompson, P. M., Kauwe, J. S. K., Kaddurah-Daouk, R., Green, R. C., Toga, A. W. & Weiner, M. W., Jul 1 2015, In : Alzheimer's and Dementia. 11, 7, p. 792-814 23 p.

Research output: Contribution to journalReview article

102 Scopus citations

GN-SCCA: Graphnet based sparse canonical correlation analysis for brain imaging genetics

Du, L., Yan, J., Kim, S., Risacher, S. L., Huang, H., Inlow, M., Moore, J. H., Saykin, A. J., Shen, L. & Alzheimer’s Disease Neuroimaging Initiative, D. N. I., 2015, Brain Informatics and Health - 8th International Conference, BIH 2015, Proceedings. Guo Y., Y., Hill S., S., Friston, K., Peng, H. & Faisal A., A. (eds.). Springer Verlag, p. 275-284 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9250).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Graphic Mining of High-Order Drug Interactions and Their Directional Effects on Myopathy Using Electronic Medical Records

Du, L., Chakraborty, A., Chiang, C. W., Cheng, L., Quinney, S. K., Wu, H., Zhang, P., Li, L. & Shen, L., Aug 1 2015, In : CPT: Pharmacometrics and Systems Pharmacology. 4, 8, p. 481-488 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP

Ramanan, V. K., Risacher, S. L., Nho, K., Kim, S., Shen, L., McDonald, B. C., Yoder, K. K., Hutchins, G. D., West, J. D., Tallman, E. F., Gao, S., Foroud, T. M., Farlow, M. R., De Jager, P. L., Bennett, D. A., Aisen, P. S., Petersen, R. C., Jack, C. R., Toga, A. W., Green, R. C. & 3 others, Jagust, W. J., Weiner, M. W. & Saykin, A. J., Oct 1 2015, In : Brain. 138, 10, p. 3076-3088 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative, 2015, In : Frontiers in Genetics. 6, MAR, 117.

Research output: Contribution to journalArticle

12 Scopus citations

Identifying connectome module patterns via new balanced multi-graph normalized cut

Gao, H., Cai, C., Yan, J., Yan, L., Cortes, J. G., Wang, Y., Nie, F., West, J., Saykin, A., Shen, L. & Huang, H., Jan 1 2015, Medical Image Computing and Computer-Assisted Intervention - MICCAI 2015 - 18th International Conference, Proceedings. Hornegger, J., Frangi, A. F., Wells, W. M., Frangi, A. F., Navab, N., Hornegger, J., Navab, N., Wells, W. M., Wells, W. M., Frangi, A. F., Hornegger, J. & Navab, N. (eds.). Springer Verlag, p. 169-176 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9350).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Integrated visualization of human brain connectome data

Li, H., Fang, S., Goni, J., Contreras, J. A., Liang, Y., Cai, C., West, J. D., Risacher, S. L., Wang, Y., Sporns, O., Saykin, A., Shen, L. & ADNI, 2015, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Springer Verlag, Vol. 9250. p. 295-305 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9250).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Large-scale genomics unveil polygenic architecture of human cortical surface area

Chen, C. H., Peng, Q., Schork, A. J., Lo, M. T., Fan, C. C., Wang, Y., Desikan, R. S., Bettella, F., Hagler, D. J., Westlye, L. T., Kremen, W. S., Jernigan, T. L., Le Hellard, S., Steen, V. M., Espeseth, T., Huentelman, M., Håberg, A. K., Agartz, I., Djurovic, S., Andreassen, O. A. & 86 others, Schork, N., Dale, A. M., McCabe, C., Chang, L., Akshoomoff, N., Newman, E., Ernst, T., Van Zijl, P., Kuperman, J., Murray, S., Bloss, C., Appelbaum, M., Gamst, A., Thompson, W., Bartsch, H., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., Khachaturian, Z., Sorensen, G., Carrillo, M., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulman, M. M., Potter, W., Snyder, P. J., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Harvey, D., Bernstein, M., Fox, N., Thompson, P., Schuff, N., DeCarli, C., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Householder, E., Taylor-Reinwald, L., Lee, V. M. Y., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Faber, K., Kim, S., Nho, K., Thal, L., Frank, R., Buckholtz, N., Albert, M. & Hsiao, J., Jul 20 2015, In : Nature communications. 6, 7549.

Research output: Contribution to journalArticle

23 Scopus citations

Protective variant for hippocampal atrophy identified by whole exome sequencing

Nho, K., Kim, S., Risacher, S. L., Shen, L., Corneveaux, J. J., Swaminathan, S., Lin, H., Ramanan, V. K., Liu, Y., Foroud, T. M., Inlow, M. H., Siniard, A. L., Reiman, R. A., Aisen, P. S., Petersen, R. C., Green, R. C., Jack, C. R., Weiner, M. W., Baldwin, C. T., Lunetta, K. L. & 14 others, Farrer, L. A., Furney, S. J., Lovestone, S., Simmons, A., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., McDonald, B. C., Farlow, M. R., Ghetti, B., Huentelman, M. J. & Saykin, A. J., Mar 1 2015, In : Annals of neurology. 77, 3, p. 547-552 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Surface-based morphometric analysis of hippocampal subfields in mild cognitive impairment and Alzheimer's disease

Cong, S., Rizkalla, M., Salama, P., West, J., Risacher, S., Saykin, A. & Shen, L., Sep 28 2015, IEEE 58th International Midwest Symposium on Circuits and Systems: Climbing to New Heights, MWSCAS 2015 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 7282173. (Midwest Symposium on Circuits and Systems; vol. 2015-September).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

The role of visualization and 3-D printing in biological data mining

Weiss, T. L., Zieselman, A., Hill, D. P., Diamond, S. G., Shen, L., Saykin, A. J., Moore, J. H. & Alzheimer's Disease Neuroimaging Initiative, D. N. I., Aug 5 2015, In : BioData Mining. 8, 1, 56.

Research output: Contribution to journalArticle

4 Scopus citations

Two-dimensional enrichment analysis for mining high-level imaging genetic associations

Yao, X., Yan, J., Kim, S., Nho, K., Risacher, S. L., Inlow, M., Moore, J. H., Saykin, A. J., Shen, L. & The Alzheimer’s Disease Neuroimaging Initiative, A. D. N. I., 2015, Brain Informatics and Health - 8th International Conference, BIH 2015, Proceedings. Guo Y., Y., Hill S., S., Friston, K., Peng, H. & Faisal A., A. (eds.). Springer Verlag, p. 115-124 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9250).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations
2014

Accelerating sparse canonical correlation analysis for large brain imaging genetics data

Yan, J., Zhang, H., Du, L., Wernert, E., Saykin, A. J. & Shen, L., Jan 1 2014, Proceedings of the XSEDE 2014 Conference: Engaging Communities. Association for Computing Machinery, 4. (ACM International Conference Proceeding Series).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

A novel structure-aware sparse learning algorithm for brain imaging genetics

Du, L., Yan, J., Kim, S., Risacher, S. L., Huang, H., Inlow, M., Moore, J. H., Saykin, A. J. & Shen, L., 2014, Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings. PART 3 ed. Springer Verlag, p. 329-336 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 8675 LNCS, no. PART 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Scopus citations

APOE and BCHE as modulators of cerebral amyloid deposition: A florbetapir PET genome-wide association study

Ramanan, V. K., Risacher, S. L., Nho, K., Kim, S., Swaminathan, S., Shen, L., Foroud, T. M., Hakonarson, H., Huentelman, M. J., Aisen, P. S., Petersen, R. C., Green, R. C., Jack, C. R., Koeppe, R. A., Jagust, W. J., Weiner, M. W. & Saykin, A. J., Mar 1 2014, In : Molecular Psychiatry. 19, 3, p. 351-357 7 p.

Research output: Contribution to journalArticle

119 Scopus citations

Association of plasma and cortical amyloid beta is modulated by APOE ε4 status

Swaminathan, S., Risacher, S. L., Yoder, K. K., West, J. D., Shen, L., Kim, S., Inlow, M., Foroud, T., Jagust, W. J., Koeppe, R. A., Mathis, C. A., Shaw, L. M., Trojanowski, J. Q., Soares, H., Aisen, P. S., Petersen, R. C., Weiner, M. W. & Saykin, A. J., Jan 2014, In : Alzheimer's and Dementia. 10, 1, p. e9-e18

Research output: Contribution to journalArticle

26 Scopus citations

Building a surface atlas of hippocampal subfields from MRI scans using FreeSurfer, FIRST and SPHARM

Cong, S., Rizkalla, M., Du, E. Y., West, J., Risacher, S., Saykin, A. & Shen, L., Sep 23 2014, 2014 IEEE 57th International Midwest Symposium on Circuits and Systems, MWSCAS 2014. Institute of Electrical and Electronics Engineers Inc., p. 813-816 4 p. 6908539. (Midwest Symposium on Circuits and Systems).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Computational genetics analysis of grey matter density in Alzheimer's disease

Zieselman, A. L., Fisher, J. M., Hu, T., Andrews, P. C., Greene, C. S., Shen, L., Saykin, A. J. & Moore, J. H., Aug 22 2014, In : BioData Mining. 7, 1, 17.

Research output: Contribution to journalArticle

5 Scopus citations

Data synthesis and method evaluation for brain imaging genetics

Sheng, J., Kim, S., Yan, J., Moore, J., Saykin, A. & Shen, L., Jul 29 2014, 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., p. 1202-1205 4 p. 6868091. (2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Genetic analysis of quantitative phenotypes in AD and MCI: Imaging, cognition and biomarkers

Shen, L., Thompson, P. M., Potkin, S. G., Bertram, L., Farrer, L. A., Foroud, T. M., Green, R. C., Hu, X., Huentelman, M. J., Kim, S., Kauwe, J. S. K., Li, Q., Liu, E., Macciardi, F., Moore, J. H., Munsie, L., Nho, K., Ramanan, V. K., Risacher, S. L., Stone, D. J. & 4 others, Swaminathan, S., Toga, A. W., Weiner, M. W. & Saykin, A. J., Jun 2014, In : Brain Imaging and Behavior. 8, 2, p. 183-207 25 p.

Research output: Contribution to journalArticle

87 Scopus citations

Human connectome module pattern detection using a new multi-graph MinMax cut model

Wang, D., Wang, Y., Nie, F., Yan, J., Cai, W., Saykin, A. J., Shen, L. & Huang, H., Jan 1 2014, Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings. PART 3 ed. Springer Verlag, p. 313-320 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 8675 LNCS, no. PART 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Human connectome module pattern detection using a new multi-graph MinMax cut model.

De, W., Wang, Y., Nie, F., Yan, J., Cai, W., Saykin, A., Shen, L. & Huang, H., 2014, Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 3 ed. Vol. 17. p. 313-320 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Identifying the neuroanatomical basis of cognitive impairment in Alzheimer's disease by correlation-and nonlinearity-aware sparse bayesian learning

Wan, J., Zhang, Z., Rao, B. D., Fang, S., Yan, J., Saykin, A. J. & Shen, L., Jul 2014, In : IEEE Transactions on Medical Imaging. 33, 7, p. 1475-1487 13 p., 6781587.

Research output: Contribution to journalArticle

27 Scopus citations

Improving protein order-disorder classification using charge-hydropathy plots

Huang, F., Oldfield, C. J., Xue, B., Hsu, W. L., Meng, J., Liu, X., Shen, L., Romero, P., Uversky, V. N. & Dunker, A. K., Dec 16 2014, In : BMC bioinformatics. 15, 17, S4.

Research output: Contribution to journalArticle

32 Scopus citations

Joint identification of imaging and proteomics biomarkers of alzheimer's disease using network-guided sparse learning

Yan, J., Huang, H., Kim, S., Moore, J., Saykin, A. & Shen, L., Jul 29 2014, 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., p. 665-668 4 p. 6867958. (2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M. J., Martin, N. G., Agartz, I., Alda, M., Alhusaini, S., Almasy, L., Almeida, J., Alpert, K., Andreasen, N. C., Andreassen, O. A. & 269 others, Apostolova, L. G., Appel, K., Armstrong, N. J., Aribisala, B., Bastin, M. E., Bauer, M., Bearden, C. E., Bergmann, Ø., Binder, E. B., Blangero, J., Bockholt, H. J., Bøen, E., Bois, C., Boomsma, D. I., Booth, T., Bowman, I. J., Bralten, J., Brouwer, R. M., Brunner, H. G., Brohawn, D. G., Buckner, R. L., Buitelaar, J., Bulayeva, K., Bustillo, J. R., Calhoun, V. D., Cannon, D. M., Cantor, R. M., Carless, M. A., Caseras, X., Cavalleri, G. L., Chakravarty, M. M., Chang, K. D., Ching, C. R. K., Christoforou, A., Cichon, S., Clark, V. P., Conrod, P., Coppola, G., Crespo-Facorro, B., Curran, J. E., Czisch, M., Deary, I. J., de Geus, E. J. C., den Braber, A., Delvecchio, G., Depondt, C., de Haan, L., de Zubicaray, G. I., Dima, D., Dimitrova, R., Djurovic, S., Dong, H., Donohoe, G., Duggirala, R., Dyer, T. D., Ehrlich, S., Ekman, C. J., Elvsåshagen, T., Emsell, L., Erk, S., Espeseth, T., Fagerness, J., Fears, S., Fedko, I., Fernández, G., Fisher, S. E., Foroud, T., Fox, P. T., Francks, C., Frangou, S., Frey, E. M., Frodl, T., Frouin, V., Garavan, H., Giddaluru, S., Glahn, D. C., Godlewska, B., Goldstein, R. Z., Gollub, R. L., Grabe, H. J., Grimm, O., Gruber, O., Guadalupe, T., Gur, R. E., Gur, R. C., Göring, H. H. H., Hagenaars, S., Hajek, T., Hall, G. B., Hall, J., Hardy, J., Hartman, C. A., Hass, J., Hatton, S. N., Haukvik, U. K., Hegenscheid, K., Heinz, A., Hickie, I. B., Ho, B. C., Hoehn, D., Hoekstra, P. J., Hollinshead, M., Holmes, A. J., Homuth, G., Hoogman, M., Hong, L. E., Hosten, N., Hottenga, J. J., Hulshoff Pol, H. E., Hwang, K. S., Jack, C. R., Jenkinson, M., Johnston, C., Jönsson, E. G., Kahn, R. S., Kasperaviciute, D., Kelly, S., Kim, S., Kochunov, P., Koenders, L., Krämer, B., Kwok, J. B. J., Lagopoulos, J., Laje, G., Landen, M., Landman, B. A., Lauriello, J., Lawrie, S. M., Lee, P. H., Le Hellard, S., Lemaître, H., Leonardo, C. D., Li, C. S., Liberg, B., Liewald, D. C., Liu, X., Lopez, L. M., Loth, E., Lourdusamy, A., Luciano, M., Macciardi, F., Machielsen, M. W. J., MacQueen, G. M., Malt, U. F., Mandl, R., Manoach, D. S., Martinot, J. L., Matarin, M., Mather, K. A., Mattheisen, M., Mattingsdal, M., Meyer-Lindenberg, A., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Meisenzahl, E., Melle, I., Milaneschi, Y., Mohnke, S., Montgomery, G. W., Morris, D. W., Moses, E. K., Mueller, B. A., Muñoz Maniega, S., Mühleisen, T. W., Müller-Myhsok, B., Mwangi, B., Nauck, M., Nho, K., Nichols, T. E., Nilsson, L. G., Nugent, A. C., Nyberg, L., Olvera, R. L., Oosterlaan, J., Ophoff, R. A., Pandolfo, M., Papalampropoulou-Tsiridou, M., Papmeyer, M., Paus, T., Pausova, Z., Pearlson, G. D., Penninx, B. W., Peterson, C. P., Pfennig, A., Phillips, M., Pike, G. B., Poline, J. B., Potkin, S. G., Pütz, B., Ramasamy, A., Rasmussen, J., Rietschel, M., Rijpkema, M., Risacher, S. L., Roffman, J. L., Roiz-Santiañez, R., Romanczuk-Seiferth, N., Rose, E. J., Royle, N. A., Rujescu, D., Ryten, M., Sachdev, P. S., Salami, A., Satterthwaite, T. D., Savitz, J., Saykin, A. J., Scanlon, C., Schmaal, L., Schnack, H. G., Schork, A. J., Schulz, S. C., Schür, R., Seidman, L., Shen, L., Shoemaker, J. M., Simmons, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soares, J. C., Sponheim, S. R., Sprooten, E., Starr, J. M., Steen, V. M., Strakowski, S., Strike, L., Sussmann, J., Sämann, P. G., Teumer, A., Toga, A. W., Tordesillas-Gutierrez, D., Trabzuni, D., Trost, S., Turner, J., Van den Heuvel, M., van der Wee, N. J., van Eijk, K., van Erp, T. G. M., van Haren, N. E. M., van 't Ent, D., van Tol, M. J., Valdés Hernández, M. C., Veltman, D. J., Versace, A., Völzke, H., Walker, R., Walter, H., Wang, L., Wardlaw, J. M., Weale, M. E., Weiner, M. W., Wen, W., Westlye, L. T., Whalley, H. C., Whelan, C. D., White, T., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Zilles, D., Zwiers, M. P., Thalamuthu, A., Schofield, P. R., Freimer, N. B., Lawrence, N. S. & Drevets, W., Jun 2014, In : Brain Imaging and Behavior. 8, 2, p. 153-182 30 p.

Research output: Contribution to journalArticle

348 Scopus citations

Transcriptome-guided amyloid imaging genetic analysis via a novel structured sparse learning algorithm

Yan, J., Du, L., Kim, S., Risacher, S. L., Huang, H., Moore, J. H., Saykin, A. J. & Shen, L., Sep 1 2014, In : Bioinformatics. 30, 17, p. i564-i571

Research output: Contribution to journalArticle

30 Scopus citations
2013

A graph-based integration of multimodal brain imaging data for the detection of early mild cognitive impairment (E-MCI)

Kim, D., Kim, S., Risacher, S. L., Shen, L., Ritchie, M. D., Weiner, M. W., Saykin, A. J. & Nho, K., 2013, Multimodal Brain Image Analysis - Third International Workshop, MBIA 2013, Held in Conjunction with MICCAI 2013, Proceedings. p. 159-169 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 8159 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations