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  • Martin Farlow
2020

Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning

Castillo-Barnes, D., Su, L., Ramírez, J., Salas-Gonzalez, D., Martinez-Murcia, F. J., Illan, I. A., Segovia, F., Ortiz, A., Cruchaga, C., Farlow, M. R., Xiong, C., Graff-Radford, N. R., Schofield, P. R., Masters, C. L., Salloway, S., Jucker, M., Mori, H., Levin, J., Gorriz, J. M. & (DIAN), D. I. A. N., Jun 2020, In : Information Fusion. 58, p. 153-167 15 p.

Research output: Contribution to journalArticle

2019

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

A randomized, double-blind, placebo-controlled, phase II study assessing safety, tolerability, and efficacy of bryostatin in the treatment of moderately severe to severe Alzheimer's disease

Farlow, M. R., Thompson, R. E., Wei, L. J., Tuchman, A. J., Grenier, E., Crockford, D., Wilke, S., Benison, J., Alkon, D. L. & Moreira, P., Jan 1 2019, In : Journal of Alzheimer's Disease. 67, 2, p. 555-570 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

Llibre-Guerra, J. J., Li, Y., Schindler, S. E., Gordon, B. A., Fagan, A. M., Morris, J. C., Benzinger, T. L. S., Hassenstab, J., Wang, G., Allegri, R., Berman, S. B., Chhatwal, J., Farlow, M. R., Holtzman, D. M., Jucker, M., Levin, J., Noble, J. M., Salloway, S., Schofield, P., Karch, C. & 4 others, Fox, N. C., Xiong, C., Bateman, R. J. & McDade, E., Dec 2 2019, In : JAMA Network Open. 2, 12, p. e1917126

Research output: Contribution to journalArticle

Open Access

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Sep 1 2019, In : Nature genetics. 51, 9, p. 1423-1424 2 p.

Research output: Contribution to journalComment/debate

Open Access

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease

Vöglein, J., Paumier, K., Jucker, M., Preische, O., McDade, E., Hassenstab, J., Benzinger, T. L., Noble, J. M., Berman, S. B., Graff-Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J., Salloway, S., Xiong, C., Karch, C. M., Cairns, N., Mori, H., Schofield, P. R., Masters, C. L. & 16 others, Goate, A., Buckles, V., Fox, N., Rossor, M., Chrem, P., Allegri, R., Ringman, J. M., Höglinger, G., Steiner, H., Dieterich, M., Haass, C., Laske, C., Morris, J. C., Bateman, R. J., Danek, A. & Levin, J., Jan 1 2019, In : Brain. 142, 5, p. 1429-1440 12 p., awz050.

Research output: Contribution to journalArticle

3 Scopus citations

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

Su, Y., Flores, S., Wang, G., Hornbeck, R. C., Speidel, B., Joseph-Mathurin, N., Vlassenko, A. G., Gordon, B. A., Koeppe, R. A., Klunk, W. E., Jack, C. R., Farlow, M. R., Salloway, S., Snider, B. J., Berman, S. B., Roberson, E. D., Brosch, J., Jimenez-Velazques, I., van Dyck, C. H., Galasko, D. & 25 others, Yuan, S. H., Jayadev, S., Honig, L. S., Gauthier, S., Hsiung, G. Y. R., Masellis, M., Brooks, W. S., Fulham, M., Clarnette, R., Masters, C. L., Wallon, D., Hannequin, D., Dubois, B., Pariente, J., Sanchez-Valle, R., Mummery, C., Ringman, J. M., Bottlaender, M., Klein, G., Milosavljevic-Ristic, S., McDade, E., Xiong, C., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 180-190 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions

Elmaleh, D. R., Farlow, M. R., Conti, P. S., Tompkins, R. G., Kundakovic, L. & Tanzi, R. E., Jan 1 2019, In : Journal of Alzheimer's Disease. 71, 3, p. 715-732 18 p.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

139 Scopus citations

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 others, Finger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M. M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Ertekin-Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff-Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R., Jun 1 2019, In : Acta Neuropathologica. 137, 6, p. 879-899 21 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Scientific reports. 9, 1, 14498.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

Balasubramaniam, M., Parcon, P. A., Bose, C., Liu, L., Jones, R. A., Farlow, M. R., Mrak, R. E., Barger, S. W. & Griffin, W. S. T., Dec 27 2019, In : Journal of Neuroinflammation. 16, 1, 275.

Research output: Contribution to journalArticle

Open Access

IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease

Gu, H., Kirchhein, Y., Zhu, T., Zhao, G., Peng, H., Du, E., Liu, J., Mastrianni, J. A., Farlow, M. R., Dodel, R. & Du, Y., Apr 1 2019, In : Molecular Neurobiology. 56, 4, p. 2353-2361 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 13845.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Nature communications. 10, 1, 3310.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

for Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 1952.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

for the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 2235.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer’s Dementia

for the Alzheimer’s Disease Neuroimaging Initiative, Jul 1 2019, In : Molecular Neurobiology. 56, 7, p. 4916-4924 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Resting state network modularity along the prodromal late onset Alzheimer's disease continuum

Contreras, J. A., Avena-Koenigsberger, A., Risacher, S. L., West, J. D., Tallman, E., McDonald, B. C., Farlow, M. R., Apostolova, L. G., Goñi, J., Dzemidzic, M., Wu, Y. C., Kessler, D., Jeub, L., Fortunato, S., Saykin, A. J. & Sporns, O., Jan 1 2019, In : NeuroImage: Clinical. 22, 101687.

Research output: Contribution to journalArticle

6 Scopus citations

Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research

Hampel, H., Mesulam, M. M., Cuello, A. C., Khachaturian, A. S., Vergallo, A., Farlow, M. R., Snyder, P. J., Giacobini, E. & Khachaturian, Z. S., Jan 1 2019, In : The journal of prevention of Alzheimer's disease. 6, 1, p. 2-15 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Feb 1 2019, In : Nature Medicine. 25, 2, p. 277-283 7 p.

Research output: Contribution to journalArticle

82 Scopus citations

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Nature communications. 10, 1, 1766.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Type 2 diabetes mellitus, brain atrophy, and cognitive decline

Moran, C., Beare, R., Wang, W., Callisaya, M., Srikanth, V., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Liu, E., Montine, T., Gamst, A., Thomas, R. G. & 234 others, Donohue, M., Walter, S., Gessert, D., Sather, T., Harvey, D., Kornak, J., Dale, A., Bernstein, M., Felmlee, J., Fox, N., Thompson, P., Schuff, N., Alexander, G., Decarli, C., Bandy, D., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Cairns, N. J., Taylor-Reinwald, L., Trojanowki, J. Q., Shaw, L., Lee, V. M. Y., Korecka, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Kachaturian, Z., Frank, R., Snyder, P. J., Molchan, S., Kaye, J., Quinn, J., Lind, B., Dolen, S., Schneider, L. S., Pawluczyk, S., Spann, B. M., Brewer, J., Vanderswag, H., Heidebrink, J. L., Lord, J. L., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Stern, Y., Honig, L. S., Bell, K. L., Morris, J. C., Ances, B., Carroll, M., Leon, S., Mintun, M. A., Schneider, S., Marson, D., Griffith, R., Clark, D., Grossman, H., Mitsis, E., Romirowsky, A., Detoledo-Morrell, L., Shah, R. C., Duara, R., Varon, D., Roberts, P., Albert, M., Onyike, C., Kielb, S., Rusinek, H., De Leon, M. J., Glodzik, L., De Santi, S., Doraiswamy, P. M., Petrella, J. R., Coleman, R. E., Arnold, S. E., Karlawish, J. H., Wolk, D., Smith, C. D., Jicha, G., Hardy, P., Lopez, O. L., Oakley, M., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Mulnard, R. A., Thai, G., McAdams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Diaz-Arrastia, R., King, R., Weiner, M., Martin-Cook, K., Devous, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Anderson, H. S., Swerdlow, R. H., Apostolova, L., Lu, P. H., Bartzokis, G., Silverman, D. H. S., Graff-Radford, N. R., Parfitt, F., Johnson, H., Farlow, M. R., Hake, A. M., Matthews, B. R., Herring, S., Van Dyck, C. H., Carson, R. E., Macavoy, M. G., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Kertesz, A., Rogers, J., Trost, D., Bernick, C., Munic, D., Kerwin, D., Mesulam, M. M., Lipowski, K., Wu, C. K., Johnson, N., Sadowsky, C., Martinez, W., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Frey, M., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Obisesan, T. O., Wolday, S., Bwayo, S. K., Lerner, A., Hudson, L., Ogrocki, P., Fletcher, E., Carmichael, O., Olichney, J., Kittur, S., Borrie, M., Bartha, D. R., Johnson, S., Asthana, S., Carlsson, C. M., Potkin, S. G., Preda, A., Nguyen, D., Tariot, P., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Santulli, R. B., Schwartz, E. S., Sink, K. M., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Mintzer, J., Longmire, C. F., Spicer, K., Finger, E., Rachinsky, I., Drost, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Boles Ponto, L. L., Shim, H., Smith, K. E., Relkin, N., Chaing, G., Raudin, L., Smith, A., Fargher, K. & Raj, B. A., Feb 19 2019, In : Neurology. 92, 8, p. E823-E830

Research output: Contribution to journalArticle

8 Scopus citations

White matter alterations in early-stage Alzheimer's disease: A tract-specific study

Wen, Q., Mustafi, S. M., Li, J., Risacher, S. L., Tallman, E., Brown, S. A., West, J. D., Harezlak, J., Farlow, M. R., Unverzagt, F. W., Gao, S., Apostolova, L. G., Saykin, A. J. & Wu, Y. C., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 576-587 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment

Capouch, S. D., Farlow, M. R. & Brosch, J. R., Dec 1 2018, In : Neurology and Therapy. 7, 2, p. 249-263 15 p.

Research output: Contribution to journalReview article

4 Scopus citations

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Mahjoub, I., Mahjoub, M. A., Rekik, I., Weiner, M., Aisen, P., Petersen, R., Jack, C., Jagust, W., Trojanowki, J., Toga, A., Beckett, L., Green, R., Saykin, A., Morris, J., Shaw, L., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R. & 221 others, Dolen, S., Schneider, L., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J., Lord, J., Mason, S., Albers, C., Knopman, D., Johnson, K., Doody, R., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L., Bell, K., Ances, B., Carroll, M., Creech, M., Franklin, E., Mintun, M., Schneider, S., Oliver, A., Marson, D., Grifth, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., Grossman, H., Mitsis, E., Shah, R., Detoledo-Morrell, L., Duara, R., Varon, D., Greig, M., Roberts, P., Albert, M., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J., Cerbone, B., Michel, C., Pogorelec, D., Rusinek, H., De Leon, M., Glodzik, L., De Santi, S., Doraiswamy, P., Petrella, J., Borges-Neto, S., Wong, T., Coleman, E., Smith, C., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A., Goldstein, B., Martin, K., Makino, K., Ismail, M., Brand, C., Mulnard, R., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A., Lah, J., Cellar, J., Burns, J., Swerdlow, R., Brooks, W., Apostolova, L., Tingus, K., Woo, E., Silverman, D., Lu, P., Bartzokis, G., Graf-Radford, N., Parftt, F., Kendall, T., Johnson, H., Farlow, M., Hake, A. M., Matthews, B., Brosch, J., Herring, S., Hunt, C., Dyck, C., Carson, R., MacAvoy, M., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M. M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R., Johnson, K., Marshall, G., Yesavage, J., Taylor, J., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Sirrel, S., Kowall, N., Killiany, R., Budson, A., Norbash, A., Johnson, P. L., Obisesan, T., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C., Potkin, S., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D., Kataki, M., Adeli, A., Zimmerman, E., Celmins, D., Brown, A., Pearlson, G., Blank, K., Anderson, K., Flashman, L., Seltzer, M., Hynes, M., Santulli, R., Sink, K., Gordineer, L., Williamson, J., Garg, P., Watkins, F., Ott, B., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H., Miller, B., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Raj, B. A. & Fargher, K., Dec 1 2018, In : Scientific reports. 8, 1, 4103.

Research output: Contribution to journalArticle

24 Scopus citations

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

for the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific reports. 8, 1, 13807.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations

Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET

Risacher, S. L., Farlow, M. R., Bateman, D. R., Epperson, F., Tallman, E. F., Richardson, R., Murrell, J. R., Unverzagt, F. W., Apostolova, L. G., Bonnin, J. M., Ghetti, B. & Saykin, A. J., Oct 29 2018, In : Acta neuropathologica communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease

on behalf of the Dominantly Inherited Alzheimer Network, Sep 2018, In : Annals of neurology. 84, 3, p. 424-435 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease

NIA-LOAD family study group & NCRAD, Apr 4 2018, In : Frontiers in Neuroscience. 12, APR, 209.

Research output: Contribution to journalArticle

3 Scopus citations

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI, Jan 1 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 595-598 4 p.

Research output: Contribution to journalArticle

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

Karch, C. M., Hernández, D., Wang, J. C., Marsh, J., Hewitt, A. W., Hsu, S., Norton, J., Levitch, D., Donahue, T., Sigurdson, W., Ghetti, B., Farlow, M., Chhatwal, J., Berman, S., Cruchaga, C., Morris, J. C., Bateman, R. J., Pébay, A. & Goate, A. M., Jul 25 2018, In : Alzheimer's Research and Therapy. 10, 1, 69.

Research output: Contribution to journalArticle

4 Scopus citations

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

McDade, E., Wang, G., Gordon, B. A., Hassenstab, J., Benzinger, T. L. S., Buckles, V., Fagan, A. M., Holtzman, D. M., Cairns, N. J., Goate, A. M., Marcus, D. S., Morris, J. C., Paumier, K., Xiong, C., Allegri, R., Berman, S. B., Klunk, W., Noble, J., Ringman, J., Ghetti, B. & 12 others, Farlow, M., Sperling, R. A., Chhatwal, J., Salloway, S., Graff-Radford, N. R., Schofield, P. R., Masters, C., Rossor, M. N., Fox, N. C., Levin, J., Jucker, M. & Bateman, R. J., Oct 2 2018, In : Neurology. 91, 14, p. E1295-E1306

Research output: Contribution to journalArticle

29 Scopus citations

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific reports. 8, 1, 5697.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing

Chhatwal, J. P., Schultz, A. P., Johnson, K. A., Hedden, T., Jaimes, S., Benzinger, T. L. S., Jack, C., Ances, B. M., Ringman, J. M., Marcus, D. S., Ghetti, B., Farlow, M. R., Danek, A., Levin, J., Yakushev, I., Laske, C., Koeppe, R. A., Galasko, D. R., Xiong, C., Masters, C. L. & 10 others, Schofield, P. R., Kinnunen, K. M., Salloway, S., Martins, R. N., McDade, E., Cairns, N. J., Buckles, V. D., Morris, J. C., Bateman, R. & Sperling, R. A., May 1 2018, In : Brain. 141, 5, p. 1486-1500 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study

for the & Dominantly Inherited Alzheimer Network (DIAN), Jan 2018, In : Alzheimer's and Dementia. 14, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Randomized, controlled, proof-of-concept trial of MK-7622 in Alzheimer's disease

Voss, T., Li, J., Cummings, J., Farlow, M., Assaid, C., Froman, S., Leibensperger, H., Snow-Adami, L., McMahon, K. B., Egan, M. & Michelson, D., Jan 1 2018, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 173-181 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In : JAMA Neurology. 75, 8, p. 989-998 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Dec 1 2018, In : Acta Neuropathologica. 136, 6, p. 857-872 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

The cholinergic system in the pathophysiology and treatment of Alzheimer's disease

Hampel, H., Mesulam, M. M., Cuello, A. C., Farlow, M. R., Giacobini, E., Grossberg, G. T., Khachaturian, A. S., Vergallo, A., Cavedo, E., Snyder, P. J. & Khachaturian, Z. S., Jul 1 2018, In : Brain. 141, 7, p. 1917-1933 17 p.

Research output: Contribution to journalReview article

94 Scopus citations

Treatment developments in Alzheimer's disease

Farlow, M., Mar 1 2018, In : European Neurological Review. 14, 1, p. 17-18 2 p.

Research output: Contribution to journalArticle

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

The Genetic FTD Initiative (GENFI) & The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2018, In : Nature communications. 9, 1, 4273.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study

Vandenberghe, R., Riviere, M. E., Caputo, A., Sovago, J., Maguire, R. P., Farlow, M., Marotta, G., Sanchez-Valle, R., Scheltens, P., Ryan, J. M. & Graf, A., Jan 1 2017, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3, 1, p. 10-22 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

An amylin analog used as a challenge test for Alzheimer's disease

Zhu, H., Stern, R. A., Tao, Q., Bourlas, A., Essis, M. D., Chivukula, M., Rosenzweig, J., Steenkamp, D., Xia, W., Mercier, G. A., Tripodis, Y., Farlow, M., Kowall, N. & Qiu, W. Q., Jan 1 2017, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease

Alzheimer's Disease Neuroimaging Initiative, May 2017, In : JAMA Neurology. 74, 5, p. 557-566 10 p.

Research output: Contribution to journalArticle

174 Scopus citations

Benefits and harms of atypical antipsychotics for agitation in adults with dementia

Farlow, M. & Shamliyan, T. A., Mar 1 2017, In : European Neuropsychopharmacology. 27, 3, p. 217-231 15 p.

Research output: Contribution to journalReview article

21 Scopus citations

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features

Singanamalli, A., Wang, H., Madabhushi, A., Weiner, M., Aisen, P., Petersen, R., Jack, C., Jagust, W., Trojanowki, J., Toga, A., Beckett, L., Green, R., Saykin, A., Morris, J., Shaw, L., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R. & 221 others, Dolen, S., Schneider, L., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J., Lord, J., Mason, S., Albers, C., Knopman, D., Johnson, K., Doody, R., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L., Bell, K., Ances, B., Carroll, M., Creech, M., Franklin, E., Mintun, M., Schneider, S., Oliver, A., Marson, D., Griffith, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., Grossman, H., Mitsis, E., Shah, R., Detoledo-Morrell, L., Duara, R., Varon, D., Greig, M., Roberts, P., Albert, M., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J., Cerbone, B., Michel, C., Pogorelec, D., Rusinek, H., De Leon, M., Glodzik, L., De Santi, S., Doraiswamy, P., Petrella, J., Borges-Neto, S., Wong, T., Coleman, E., Smith, C., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A., Goldstein, B., Martin, K., Makino, K., Ismail, M., Brand, C., Mulnard, R., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A., Lah, J., Cellar, J., Burns, J., Swerdlow, R., Brooks, W., Apostolova, L., Tingus, K., Woo, E., Silverman, D., Lu, P., Bartzokis, G., Graff-Radford, N., Parfitt, F., Kendall, T., Johnson, H., Farlow, M., Marie Hake, A., Matthews, B., Brosch, J., Herring, S., Hunt, C., Dyck, C., Carson, R., MacAvoy, M., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M. M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Scott Turner, R., Johnson, K., Reynolds, B., Sperling, R., Johnson, K., Marshall, G., Yesavage, J., Taylor, J., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Sirrel, S., Kowall, N., Killiany, R., Budson, A., Norbash, A., Lynn Johnson, P., Obisesan, T., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Robbartha, Johnson, S., Asthana, S., Carlsson, C., Potkin, S., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D., Kataki, M., Adeli, A., Zimmerman, E., Celmins, D., Brown, A., Pearlson, G., Blank, K., Anderson, K., Flashman, L., Seltzer, M., Hynes, M., Santulli, R., Sink, K., Gordineer, L., Williamson, J., Garg, P., Watkins, F., Ott, B., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H., Miller, B., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Ashok Raj, B. & Fargher, K., Dec 1 2017, In : Scientific reports. 7, 1, 8137.

Research output: Contribution to journalArticle

3 Scopus citations

Cognitive complaints in older adults at risk for Alzheimer's disease are associated with altered resting-state networks

Contreras, J. A., Goñi, J., Risacher, S. L., Amico, E., Yoder, K., Dzemidzic, M., West, J. D., McDonald, B. C., Farlow, M. R., Sporns, O. & Saykin, A. J., Jan 1 2017, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 6, p. 40-49 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Donepezil Plus Solifenacin (CPC-201) Treatment for Alzheimer’s Disease

Chase, T. N., Farlow, M. R. & Clarence-Smith, K., Apr 1 2017, In : Neurotherapeutics. 14, 2, p. 405-416 12 p.

Research output: Contribution to journalArticle

9 Scopus citations