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2020

Clinicopathologic analysis of upper urinary tract carcinoma with variant histology

Rolim, I., Henriques, V., Rolim, N., Blanca, A., Marques, R. C., Volavšek, M., Carvalho, I., Montironi, R., Cimadamore, A., Raspollini, M. R., Cheng, L. & Lopez-Beltran, A., Jan 1 2020, (Accepted/In press) In : Virchows Archiv.

Research output: Contribution to journalArticle

Urinary Tract
Histology
Carcinoma
Survival
Notochord

Five decades of urologic pathology: the accelerating expansion of knowledge in renal cell neoplasia

MacLennan, G. T. & Cheng, L., Jan 2020, In : Human pathology. 95, p. 24-45 22 p.

Research output: Contribution to journalArticle

Pathology
Kidney
Kidney Neoplasms
Neoplasms
Galaxies

Germline and somatic mutations in prostate cancer: Focus on defective DNA repair, PARP inhibitors and immunotherapy

Cimadamore, A., Lopez-Beltran, A., Massari, F., Santoni, M., Mazzucchelli, R., Scarpelli, M., Galosi, A. B., Cheng, L. & Montironi, R., Jan 1 2020, In : Future Oncology. 16, 5, p. 75-80 6 p.

Research output: Contribution to journalComment/debate

Gonadoblastoma: origin and outcome

Roth, L. M. & Cheng, L., Jan 1 2020, (Accepted/In press) In : Human pathology.

Research output: Contribution to journalArticle

Gonadoblastoma
Germ Cells
Gonads
Testis
Disorders of Sex Development

Microsatellite instability and mismatch repair deficiency in the era of precision immuno-oncology

Mann, S. A. & Cheng, L., Jan 2 2020, In : Expert Review of Anticancer Therapy. 20, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorial

Open Access

Molecular characteristics of testicular germ cell tumors: pathogenesis and mechanisms of therapy resistance

Al-Obaidy, K. I., Chovanec, M. & Cheng, L., Jan 1 2020, (Accepted/In press) In : Expert Review of Anticancer Therapy.

Research output: Contribution to journalEditorial

Open Access

Molecular diagnostics in uro-oncology

Montironi, R., Cheng, L., Cimadamore, A. & Lopez-Beltran, A., Jan 1 2020, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalEditorial

Open Access
Positron-Emission Tomography
Prostatic Neoplasms
Pathology
human glutamate carboxypeptidase II
Prostatectomy
2019
Lymphoma, Large B-Cell, Diffuse
Down-Regulation
MicroRNAs
Exome
Reverse Transcriptase Polymerase Chain Reaction
2 Citations (Scopus)

Activating KRAS mutations in arteriovenous malformations of the brain: frequency and clinicopathologic correlation

Priemer, D. S., Vortmeyer, A., Zhang, S., Chang, H. Y., Curless, K. L. & Cheng, L., Jul 1 2019, In : Human pathology. 89, p. 33-39 7 p.

Research output: Contribution to journalArticle

Arteriovenous Malformations
Mutation
Brain
Dura Mater
Inborn Genetic Diseases
2 Citations (Scopus)

Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: A systematic review with meta-analysis

Lawlor, R. T., Veronese, N., Pea, A., Nottegar, A., Smith, L., Pilati, C., Demurtas, J., Fassan, M., Cheng, L. & Luchini, C., Mar 14 2019, In : BMC Cancer. 19, 1, 232.

Research output: Contribution to journalReview article

Open Access
Telomere Homeostasis
Sarcoma
Meta-Analysis
Survival
Odds Ratio

An evaluation of current prostate cancer diagnostic approaches with emphasis on liquid biopsies and prostate cancer

Mollica, V., Di Nunno, V., Santoni, M., Cimadamore, A., Scarpelli, M., Lopez-Beltran, A., Cheng, L., Mariani, C., Battelli, N., Montironi, R. & Massari, F., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalReview article

Prostatic Neoplasms
Circulating Neoplastic Cells
Biopsy
Neoplasms
Castration

Annual review issue: Urologic pathology: a remarkable journey of innovation

Cheng, L. & Berney, D. M., Jan 1 2019, In : Histopathology. 74, 1, 1 p.

Research output: Contribution to journalEditorial

Pathology
3 Citations (Scopus)

A Systematic Review of the Role of Definitive Local Treatment in Patients with Clinically Lymph Node-positive Prostate Cancer

Ventimiglia, E., Seisen, T., Abdollah, F., Briganti, A., Fonteyne, V., James, N., Roach, M., Thalmann, G. N., Touijer, K., Chen, R. C. & Cheng, L., May 1 2019, In : European urology oncology. 2, 3, p. 294-301 8 p.

Research output: Contribution to journalReview article

Prostatic Neoplasms
Lymph Nodes
Androgens
Survival
Therapeutics
Neoplasms
Familial medullary thyroid carcinoma
3 Citations (Scopus)

Circulating tumor cells in renal cell carcinoma: Recent findings and future challenges

Santoni, M., Cimadamore, A., Cheng, L., Lopez-Beltran, A., Battelli, N., Massari, F., Scarpelli, M., Galosi, A. B., Bracarda, S. & Montironi, R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 228.

Research output: Contribution to journalComment/debate

Open Access
Circulating Neoplastic Cells
Renal Cell Carcinoma

Clinical utility versus futility: A tipping point for liquid biopsies in bladder cancer

Kouba, E. & Cheng, L., Jan 1 2019, In : Future Oncology. 15, 33, p. 3751-3753 3 p.

Research output: Contribution to journalReview article

Open Access
Medical Futility
Precision Medicine
Urinary Bladder Neoplasms
Urinary Bladder
Biomarkers

Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy

Magers, M. J., Kaimakliotis, H. Z., Barboza, M. P., Bandali, E., Adra, N., Koch, M. O. & Cheng, L., Jan 1 2019, In : Journal of Clinical Pathology.

Research output: Contribution to journalArticle

Cystectomy
Foreign Body Giant Cells
Carcinoma
Drug Therapy
Urinary Bladder Neoplasms
1 Citation (Scopus)

Contemporary best practice in the management of urothelial carcinomas of the renal pelvis and ureter

Bianconi, M., Cimadamore, A., Faloppi, L., Scartozzi, M., Santoni, M., Lopez-Beltran, A., Cheng, L., Scarpelli, M. & Montironi, R., Jan 1 2019, In : Therapeutic Advances in Urology. 11

Research output: Contribution to journalReview article

Kidney Pelvis
Practice Management
Ureter
Practice Guidelines
Carcinoma
1 Citation (Scopus)

Contemporary grading of prostate cancer: 2017 update for pathologists and clinicians

Gasparrini, S., Cimadamore, A., Scarpelli, M., Massari, F., Doria, A., Mazzucchelli, R., Cheng, L., Lopez-Beltran, A. & Montironi, R., Jan 1 2019, In : Asian Journal of Andrology. 21, 1, p. 19-23 5 p.

Research output: Contribution to journalReview article

Neoplasm Grading
Prostatic Neoplasms
Pathology
Pathologists
Therapeutics
1 Citation (Scopus)

Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation

Srigley, J. R., Delahunt, B., Samaratunga, H., Billis, A., Cheng, L., Clouston, D., Evans, A., Furusato, B., Kench, J., Leite, K., MacLennan, G., Moch, H., Pan, C. C., Rioux-Leclercq, N., Ro, J., Shanks, J., Shen, S., Tsuzuki, T., Varma, M., Wheeler, T. & 2 others, Yaxley, J. & Egevad, L., Aug 1 2019, In : Pathology. 51, 5, p. 463-473 11 p.

Research output: Contribution to journalReview article

Neoplasm Grading
Prostatic Neoplasms
Pathology
Internationality
Expert Testimony

Current and emerging bladder cancer biomarkers with an emphasis on urine biomarkers

Lopez-Beltran, A., Cheng, L., Gevaert, T., Blanca, A., Cimadamore, A., Santoni, M., Massari, F., Scarpelli, M., Raspollini, M. R. & Montironi, R., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalReview article

Tumor Biomarkers
Urinary Bladder Neoplasms
Biomarkers
Urine
DNA

Current progress in car-t cell therapy for solid tumors

Ma, S., Li, X., Wang, X., Cheng, L., Li, Z., Zhang, C., Ye, Z. & Qian, Q., Jan 1 2019, In : International Journal of Biological Sciences. 15, 12, p. 2548-2560 13 p.

Research output: Contribution to journalReview article

Open Access
Cell- and Tissue-Based Therapy
antigen
tumor
automobile
T-Cell Antigen Receptor
2 Citations (Scopus)

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Bungart, B., Cao, Y., Yang-Tran, T., Gorsky, S., Lan, L. U., Roblyer, D., Koch, M., Cheng, L., Masterson, T. & Cheng, J. X., Mar 1 2019, In : Biomedical Optics Express. 10, 3, p. 1405-1419 15 p., 356707.

Research output: Contribution to journalArticle

Lighting
Prostate
tomography
illumination
Tomography
3 Citations (Scopus)

Detecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies

Ye, Z., Ding, Y., Chen, Z., Li, Z., Ma, S., Xu, Z., Cheng, L., Wang, X., Zhang, X., Ding, N., Zhang, Q. & Qian, Q., Apr 3 2019, In : Cancer Biology and Therapy. 20, 4, p. 546-551 6 p.

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Aneuploidy
Neoplasms
Chromosomes, Human, Pair 8
Polyploidy
2 Citations (Scopus)

Detection of androgen receptor (AR) and AR-V7 in small cell prostate carcinoma: Diagnostic and therapeutic implications

Zhao, P., Zhu, Y., Cheng, L. & Luo, J., Jan 2019, In : Asian Journal of Urology. 6, 1, p. 109-113 5 p.

Research output: Contribution to journalArticle

Open Access
Small Cell Carcinoma
Androgen Receptors
Prostate
Therapeutics
Staining and Labeling

Digital versus light microscopy assessment of extraprostatic extension in radical prostatectomy samples

Volavšek, M., Henriques, V., Blanca, A., Montironi, R., Cheng, L., Raspollini, M. R., Cimadamore, A., Vau, N., Pierconti, F. & Lopez-Beltran, A., Dec 1 2019, In : Virchows Archiv. 475, 6, p. 735-744 10 p.

Research output: Contribution to journalArticle

Prostatectomy
Microscopy
Light
Paraffin
Prostate
1 Citation (Scopus)
Precision Medicine
Pancreatic Neoplasms
Neoplasms
Expert Testimony
Therapeutics
1 Citation (Scopus)

Distinct mutational landscape of inverted urothelial papilloma

Akgul, M., MacLennan, G. T. & Cheng, L., Jan 1 2019, In : Journal of Pathology.

Research output: Contribution to journalComment/debate

Open Access
Inverted Papilloma
Carcinoma
Mutation
MAP Kinase Signaling System
Genes

Editorial: Emerging biomarkers in genitourinary tumors

Montironi, R., Santoni, M., Cimadamore, A., Lopez-Beltran, A. & Cheng, L., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 326.

Research output: Contribution to journalEditorial

Open Access
Microbiota
Renal Cell Carcinoma
Urinary Bladder Neoplasms
Immunotherapy
Prostatic Neoplasms
5 Citations (Scopus)

Emerging molecular technologies in renal cell carcinoma: Liquid biopsy

Cimadamore, A., Gasparrini, S., Massari, F., Santoni, M., Cheng, L., Lopez-Beltran, A., Scarpelli, M. & Montironi, R., Feb 1 2019, In : Cancers. 11, 2, 196.

Research output: Contribution to journalReview article

Open Access
Renal Cell Carcinoma
Technology
Circulating Neoplastic Cells
Biopsy
Neoplasms
1 Citation (Scopus)

Expression of miR-100 and miR-138 as prognostic biomarkers in non-muscle-invasive bladder cancer

Blanca, A., Sanchez-Gonzalez, A., Requena, M. J., Carrasco-Valiente, J., Gomez-Gomez, E., Cheng, L., Cimadamore, A., Montironi, R. & Lopez-Beltran, A., Aug 1 2019, In : APMIS. 127, 8, p. 545-553 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Biomarkers
Receptor, Fibroblast Growth Factor, Type 3
Cyclin D3
Survival

Extramammary Paget disease of the penis closely mimicking the penile analogue of stratified mucin-producing intraepithelial lesion

Cimadamore, A., Scarpelli, M., Cheng, L., Lopez-Beltran, A. & Montironi, R., Apr 1 2019, In : Minerva Urologica e Nefrologica. 71, 2, p. 189-190 2 p.

Research output: Contribution to journalLetter

Extramammary Paget's Disease
Penis
Mucins

Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma: A case report

Chen, Y. H., Perrino, C. M., Cheng, L. & Wu, H., Jan 1 2019, In : Diagnostic Cytopathology.

Research output: Contribution to journalArticle

Follicular Adenocarcinoma
Fine Needle Biopsy
Cell Biology
Epithelioid Cells
Neoplasms
2 Citations (Scopus)

Genitourinary Tumors: Update on Molecular Biomarkers for Diagnosis, Prognosis and Prediction of Response to Therapy

Cimadamore, A., Scarpelli, M., Santoni, M., Massari, F., Tartari, F., Cerqueti, R., Lopez-Beltran, A., Cheng, L. & Montironi, R., Jan 1 2019, In : Current drug metabolism. 20, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

Biomarkers
Tumors
Cells
Neoplasms
Renal Cell Carcinoma

Immunotherapy in renal cell carcinoma from poverty to the spoiled of choice

Massari, F., Nunno, V. D., Mollica, V., Montironi, R., Cheng, L., Cimadamore, A., Blanca, A. & Lopez-Beltran, A., Jan 1 2019, In : Immunotherapy. 11, 17, p. 1507-1521 15 p.

Research output: Contribution to journalReview article

Poverty
Renal Cell Carcinoma
Immunotherapy
Therapeutics

Insulinoma-associated Protein 1 (INSM1) Expression in Small Cell Neuroendocrine Carcinoma of the Urinary Tract

Kim, I. E., Amin, A., Wang, L. J., Cheng, L. & Perrino, C. M., Jan 1 2019, (Accepted/In press) In : Applied Immunohistochemistry and Molecular Morphology.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Insulinoma
Small Cell Carcinoma
Urinary Tract
Proteins

Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Samaratunga, H., Delahunt, B., Egevad, L., Srigley, J. R., Billis, A., Bostwick, D. G., Camparo, P., Cheng, L., Clouston, D., Denham, J., Furusato, B., Hartmann, A., Jufe, L., Kench, J., Kenwright, D. N., Kristiansen, G., Leite, K. R. M., MacLennan, G. T., Merrimen, J., Moch, H. & 11 others, Oxley, J., Pan, C. C., Paner, G., Ro, J., Sesterhenn, I. A. M., Shanks, J., Thunders, M., Tsuzuki, T., Wheeler, T., Yaxley, J. W. & Varma, M., Jan 1 2019, (Accepted/In press) In : Pathology.

Research output: Contribution to journalReview article

Carcinoma, Intraductal, Noninfiltrating
Prostate
Carcinoma
Adenocarcinoma
1 Citation (Scopus)

Key role of obesity in genitourinary tumors with emphasis on urothelial and prostate cancers

Santoni, M., Cimadamore, A., Massari, F., Piva, F., Aurilio, G., Martignetti, A., Scarpelli, M., Di Nunno, V., Gatto, L., Battelli, N., Cheng, L., Lopez-Beltran, A. & Montironi, R., Sep 1 2019, In : Cancers. 11, 9, 1225.

Research output: Contribution to journalArticle

Open Access
Prostatic Neoplasms
Obesity
Body Mass Index
Neoplasms
docetaxel

Liquid biopsies in urological cancers: what we need to know before starting using them

Franceschini, T., Giunchi, F., Montironi, R., Scarpelli, M., Lopez-Beltran, A., Cheng, L. & Fiorentino, M., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalEditorial

Open Access
Urogenital Neoplasms
Urologic Neoplasms
Exosomes
Circulating Neoplastic Cells
Biopsy
1 Citation (Scopus)

Liquid biopsy as surrogate for tissue for molecular profiling in pancreatic cancer: A meta-analysis towards precision medicine

Luchini, C., Veronese, N., Nottegar, A., Cappelletti, V., Daidone, M. G., Smith, L., Parris, C., Brosens, L. A. A., Caruso, M. G., Cheng, L., Wolfgang, C. L., Wood, L. D., Milella, M., Salvia, R. & Scarpa, A., Aug 2019, In : Cancers. 11, 8, 1152.

Research output: Contribution to journalReview article

Open Access
Precision Medicine
Pancreatic Neoplasms
Meta-Analysis
Biopsy
Mutation Rate

Liquid biopsy in germ cell tumors: biology and clinical management

Chovanec, M., Kalavska, K., Mego, M. & Cheng, L., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalReview article

Germ Cell and Embryonal Neoplasms
Cell Biology
Biopsy
Circulating Neoplastic Cells
MicroRNAs

Liquid biopsy in the clinical management of bladder cancer: current status and future developments

Kouba, E., Lopez-Beltran, A., Montironi, R., Massari, F., Huang, K., Santoni, M., Chovanec, M., Cheng, M., Scarpelli, M., Zhang, J., Cimadamore, A. & Cheng, L., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalReview article

Urinary Bladder Neoplasms
Biopsy
Biomarkers
Circulating Neoplastic Cells
DNA
2 Citations (Scopus)

LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

Luo, J., Wang, K., Yeh, S., Sun, Y., Liang, L., Xiao, Y., Xu, W., Niu, Y., Cheng, L., Maity, S. N., Jiang, R. & Chang, C., Dec 1 2019, In : Nature communications. 10, 1, 2571.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Androgen Antagonists
Prostatic Neoplasms
cancer
Castration
4 Citations (Scopus)

Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive): a distinct entity?

Trpkov, K., Williamson, S. R., Gao, Y., Martinek, P., Cheng, L., Sangoi, A. R., Yilmaz, A., Wang, C., San Miguel Fraile, P., Perez Montiel, D. M., Bulimbasić, S., Rogala, J. & Hes, O., Jan 1 2019, In : Histopathology.

Research output: Contribution to journalArticle

Keratin-7
Kidney
Neoplasms
MART-1 Antigen
Vimentin

Microbiome and cancers, with focus on genitourinary tumors

Cimadamore, A., Santoni, M., Massari, F., Gasparrini, S., Cheng, L., Lopez-Beltran, A., Montironi, R. & Scarpelli, M., Jan 1 2019, In : Frontiers in Oncology. 9, MAR, 178.

Research output: Contribution to journalComment/debate

Open Access
Microbiota
Renal Cell Carcinoma
Immunotherapy
Prostatic Neoplasms
Neoplasms
Urinary Bladder
Adenocarcinoma
Carcinoma
Biomarkers
Cystectomy

Molecular characterization and diagnostic criteria of renal cell carcinoma with emphasis on liquid biopsies

Cimadamore, A., Massari, F., Santoni, M., Mollica, V., Di Nunno, V., Cheng, L., Lopez-Beltran, A., Scarpelli, M., Montironi, R. & Moch, H., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalReview article

Molecular Pathology
Renal Cell Carcinoma
Biopsy
Neoplasms
Long Noncoding RNA
1 Citation (Scopus)

Molecular characterization of testicular germ cell tumors: Chasing the underlying pathways

Chovanec, M. & Cheng, L., Jan 1 2019, In : Future Oncology. 15, 3, p. 227-229 3 p.

Research output: Contribution to journalEditorial

Testis
Molecular Biology
Biomarkers
Testicular Germ Cell Tumor

Molecular evidence supporting the precursor nature of atypical adenomatous hyperplasia of the prostate

Cheng, L., Montironi, R., Davidson, D., Wang, M., Lopez-Beltran, A. & Zhang, S., Jul 1 2019, In : Molecular Carcinogenesis. 58, 7, p. 1272-1278 7 p.

Research output: Contribution to journalArticle

Hyperplasia
Prostate
Telomere Shortening
Prostatic Intraepithelial Neoplasia
Adenocarcinoma