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2020

Alcohol Rehabilitation Within 30 Days of Hospital Discharge Is Associated With Reduced Readmission, Relapse, and Death in Patients With Alcoholic Hepatitis

Peeraphatdit, T. B., Kamath, P. S., Karpyak, V. M., Davis, B., Desai, V., Liangpunsakul, S., Sanyal, A., Chalasani, N., Shah, V. H. & Simonetto, D. A., Feb 2020, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 477-485.e5

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Rehabilitation
Alcohols
Recurrence
Odds Ratio

Clinical Characteristics and Adverse Impact of Hepatotoxicity due to Immune Checkpoint Inhibitors

Miller, E. D., Abu-Sbeih, H., Styskel, B., Nogueras Gonzalez, G. M., Blechacz, B., Naing, A. & Chalasani, N., Feb 1 2020, In : The American journal of gastroenterology. 115, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

Alanine Transaminase
Steroids
Preexisting Condition Coverage
Liver
Liver Failure

Non-selective beta blocker use is associated with improved short-term survival in patients with cirrhosis referred for liver transplantation

Ngwa, T., Orman, E., Gomez, E. V., Vuppalanchi, R., Kubal, C., Chalasani, N. & Ghabril, M., Jan 6 2020, In : BMC Gastroenterology. 20, 1, 4.

Research output: Contribution to journalArticle

Open Access
Liver Transplantation
Fibrosis
Survival
Acute Kidney Injury
Mortality

Spontaneous Fluctuations in Liver Biochemistries in Patients with Compensated NASH Cirrhosis: Implications for Drug Hepatotoxicity Monitoring

Shamseddeen, H., Vilar-Gomez, E., Chalasani, N., Myers, R. P., Subramanian, G. M., Shlevin, H. H., Allgood, A. E. & Orman, E. S., Jan 1 2020, (Accepted/In press) In : Drug Safety.

Research output: Contribution to journalArticle

Biochemistry
Drug Monitoring
Liver
Alanine Transaminase
Fibrosis
2019

Admission plasma uromodulin and the risk of acute kidney injury in hospitalized patients with cirrhosis: a pilot study

Patidar, K. R., Garimella, P. S., Macedo, E., Slaven, J. E., Ghabril, M. S., Weber, R. E., Anderson, M., Orman, E. S., Nephew, L. D., Desai, A. P., Chalasani, N. P. & El-Achkar, T. M., Oct 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 4, p. G447-G452

Research output: Contribution to journalArticle

Uromodulin
Acute Kidney Injury
Fibrosis
Creatinine
Urine

Advice Regarding Alcohol Use by Individuals With Nonalcoholic Fatty Liver Disease: Primum non nocere

Dunn, W. & Chalasani, N., Jan 1 2019, In : Hepatology. 69, 1, p. 9-11 3 p.

Research output: Contribution to journalEditorial

Alcohols
Non-alcoholic Fatty Liver Disease

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis

Li, W., Lin, E. L., Liangpunsakul, S., Lan, J., Chalasani, S., Rane, S., Puri, P., Kamath, P. S., Sanyal, A. J., Shah, V. H., Radaeva, S., Crabb, D., Chalasani, N. & Yu, A., Jun 1 2019, In : Clinical and translational gastroenterology. 10, 6, p. e00052

Research output: Contribution to journalArticle

Open Access
Alcohol Abstinence
Alcoholic Hepatitis
HLA Antigens
Blood Cells
Mucosal-Associated Invariant T Cells
14 Citations (Scopus)

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury

Drug-Induced Liver Injury Network (DILIN) investigators & International DILI consortium (iDILIC), May 1 2019, In : Gastroenterology. 156, 6, p. 1707-1716.e2

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Protein Tyrosine Phosphatases
Odds Ratio
Genes
Gene Frequency

Apolipoprotein B and PNPLA3 Double Heterozygosity in a Father–Son Pair With Advanced Nonalcoholic Fatty Liver Disease

Jansson-Knodell, C. L., Gawrieh, S., McIntyre, A. D., Liang, T., Hegele, R. A. & Chalasani, N., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Apolipoproteins B
Nuclear Family
Fathers
Non-alcoholic Fatty Liver Disease
1 Citation (Scopus)

Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis Clinical Research Network, Oct 2 2019, In : JAMA Network Open. 2, 10, p. e1912565

Research output: Contribution to journalArticle

Open Access
Aspartate Aminotransferases
Fibrosis
Odds Ratio
Aspartic Acid
Fatty Liver
1 Citation (Scopus)

Black Adult Patients With Acute Liver Failure Are Sicker and More Likely to Undergo Liver Transplantation Than White Patients

Nephew, L., Zia, Z., Ghabril, M., Orman, E., Lammert, C. & Chalasani, N., Jan 1 2019, (Accepted/In press) In : Liver Transplantation.

Research output: Contribution to journalArticle

Acute Liver Failure
Liver Transplantation
Hispanic Americans
End Stage Liver Disease
Survival
36 Citations (Scopus)

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort

Church, R. J., Kullak-Ublick, G. A., Aubrecht, J., Bonkovsky, H. L., Chalasani, N., Fontana, R. J., Goepfert, J. C., Hackman, F., King, N. M. P., Kirby, S., Kirby, P., Marcinak, J., Ormarsdottir, S., Schomaker, S. J., Schuppe-Koistinen, I., Wolenski, F., Arber, N., Merz, M., Sauer, J. M., Andrade, R. J. & 3 others, van Bömmel, F., Poynard, T. & Watkins, P. B., Feb 1 2019, In : Hepatology. 69, 2, p. 760-773 14 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Biomarkers
Macrophage Colony-Stimulating Factor Receptors
MicroRNAs
Glutamate Dehydrogenase
2 Citations (Scopus)

Characteristics, aetiologies and trends of hepatocellular carcinoma in patients without cirrhosis: a United States multicentre study

Gawrieh, S., Dakhoul, L., Miller, E., Scanga, A., deLemos, A., Kettler, C., Burney, H., Liu, H., Abu-Sbeih, H., Chalasani, N. & Wattacheril, J., Jan 1 2019, (Accepted/In press) In : Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Multicenter Studies
Hepatocellular Carcinoma
Fibrosis
Liver Diseases
Hepacivirus
3 Citations (Scopus)

Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis

Regev, A., Palmer, M., Avigan, M. I., Dimick-Santos, L., Treem, W. R., Marcinak, J. F., Seekins, D., Krishna, G., Anania, F. A., Freston, J. W., Lewis, J. H., Sanyal, A. J. & Chalasani, N., Mar 1 2019, In : Alimentary Pharmacology and Therapeutics. 49, 6, p. 702-713 12 p.

Research output: Contribution to journalReview article

Chemical and Drug Induced Liver Injury
Practice Guidelines
Clinical Trials
Guidelines
Liver

Consensus guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic cholestatic liver disease

Palmer, M., Regev, A., Lindor, K., Avigan, M. I., Dimick-Santos, L., Treem, W., Marcinak, J. F., Lewis, J. H., Anania, F. A., Seekins, D., Shneider, B. L. & Chalasani, N., Jan 1 2019, (Accepted/In press) In : Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journalReview article

Open Access
Chemical and Drug Induced Liver Injury
Practice Guidelines
Liver Diseases
Clinical Trials
Guidelines

Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group (PLoS ONE (2018) 13:10 (e0206389) DOI: 10.1371/journal.pone.0206389)

US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group, Feb 1 2019, In : PLoS ONE. 14, 2, e0212394.

Research output: Contribution to journalComment/debate

Open Access
Chemical and Drug Induced Liver Injury
liver failure
Acute Liver Failure
Liver
Names
Open Access
Aspirin
Fibrosis
Pharmaceutical Preparations
Non-alcoholic Fatty Liver Disease

Development and Validation of a Model Consisting of Comorbidity Burden to Calculate Risk of Death Within 6 Months for Patients With Suspected Drug-Induced Liver Injury

Ghabril, M., Gu, J., Yoder, L., Corbito, L., Ringel, A., Beyer, C. D., Vuppalanchi, R., Barnhart, H., Hayashi, P. H. & Chalasani, N., Nov 2019, In : Gastroenterology. 157, 5, p. 1245-1252.e3

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Comorbidity
Confidence Intervals
End Stage Liver Disease
Mortality

Development and Validation of a Model to Predict Acute Kidney Injury in Hospitalized Patients With Cirrhosis

Patidar, K. R., Xu, C., Shamseddeen, H., Cheng, Y. W., Ghabril, M. S., Mukthinuthalapati, V. V. P. K., Fricker, Z. P., Akinyeye, S., Nephew, L. D., Desai, A. P., Anderson, M., El-Achkar, T. M., Chalasani, N. P. & Orman, E. S., Sep 1 2019, In : Clinical and translational gastroenterology. 10, 9, p. e00075

Research output: Contribution to journalArticle

Open Access
Acute Kidney Injury
Fibrosis
End Stage Liver Disease
International Normalized Ratio
Leukocyte Count
6 Citations (Scopus)

Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage

NASH Clinical Research Network, Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Fibrosis
Blood Platelets
Aspartate Aminotransferases
Biopsy
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)

Drug-induced liver injury

Chalasani, N. & Crabb, D., Jan 1 2019, In : Gastroenterology and Hepatology. 15, 1, p. 35-37 3 p.

Research output: Contribution to journalComment/debate

Chemical and Drug Induced Liver Injury

Drug-induced liver injury

Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N. & Aithal, G. P., Dec 1 2019, In : Nature Reviews Disease Primers. 5, 1, 58.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Liver
Poisons
Adaptive Immunity
Xenobiotics
2 Citations (Scopus)
Biomarkers
Fatty Liver
Liver
Serum
Pharmaceutical Preparations

Early predictors of outcomes of hospitalization for cirrhosis and assessment of the impact of race and ethnicity at safety-net hospitals

Mukthinuthalapati, V. V. P. K., Akinyeye, S., Fricker, Z. P., Syed, M., Orman, E., Nephew, L., Vilar-Gomez, E., Slaven, J., Chalasani, N., Balakrishnan, M., Long, M. T., Attar, B. M. & Ghabril, M., Mar 1 2019, In : PLoS ONE. 14, 3, e0211811.

Research output: Contribution to journalArticle

Open Access
Safety-net Providers
nationalities and ethnic groups
Hospitalization
Fibrosis
Liver
1 Citation (Scopus)

Expanding the Donor Pool With the Use of Extended Criteria Donation After Circulatory Death Livers

Mihaylov, P., Mangus, R., Ekser, B., Cabrales, A., Timsina, L., Fridell, J., Lacerda, M., Ghabril, M., Nephew, L., Chalasani, N. & Kubal, C. A., Jan 1 2019, In : Liver Transplantation.

Research output: Contribution to journalArticle

Liver Transplantation
Liver
Warm Ischemia
Research Ethics Committees
Age Factors
5 Citations (Scopus)

Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis

Loomba, R., Sanyal, A. J., Kowdley, K. V., Terrault, N., Chalasani, N., Abdelmalek, M. F., McCullough, A. J., Shringarpure, R., Ferguson, B., Lee, L., Chen, J., Liberman, A., Shapiro, D. & Neuschwander-Tetri, B. A., Jan 1 2019, In : Gastroenterology. 156, 1, p. 88-95.e5

Research output: Contribution to journalArticle

Alanine Transaminase
Triglycerides
Placebos
International Normalized Ratio
Aspartate Aminotransferases
1 Citation (Scopus)

Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels

and the NASH Clinical Research Network, Oct 1 2019, In : The American journal of gastroenterology. 114, 10, p. 1626-1635 10 p.

Research output: Contribution to journalArticle

Transaminases
Fibrosis
Aspartate Aminotransferases
Alanine Transaminase
Histology
1 Citation (Scopus)

Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

for the NASH CRN, Jan 1 2019, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Open Access
Fatty Liver
Lipoproteins
LDL Lipoproteins
VLDL Lipoproteins
Placebos
1 Citation (Scopus)

Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury

Ahmad, J., Reddy, K. R., Tillmann, H. L., Hayashi, P. H., Chalasani, N., Fontana, R. J., Navarro, V. J., Stolz, A., Barnhart, H., Cloherty, G. A. & Hoofnagle, J. H., Jan 1 2019, In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Hepacivirus
RNA
Wounds and Injuries
Expert Testimony

Increasing Economic Burden in Hospitalized Patients With Cirrhosis: Analysis of a National Database

Desai, A. P., Mohan, P., Nokes, B., Sheth, D., Knapp, S., Boustani, M., Chalasani, N., Fallon, M. B. & Calhoun, E. A., Jul 1 2019, In : Clinical and translational gastroenterology. 10, 7, p. e00062

Research output: Contribution to journalArticle

Open Access
Fibrosis
Economics
Databases
Costs and Cost Analysis
Inpatients

Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?

Vuppalanchi, R., Weber, R., Russell, S., Gawrieh, S., Samala, N., Slaven, J. E., Harden, L. & Chalasani, N., Jun 1 2019, In : The American journal of gastroenterology. 114, 6, p. 995-997 3 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Fasting
Meals
Liver

Letter: metformin treatment and hepatocellular carcinoma risk in non-alcoholic fatty liver disease. Authors' reply

Vilar-Gomez, E. & Chalasani, N., Oct 1 2019, In : Alimentary pharmacology & therapeutics. 50, 7, p. 836-837 2 p.

Research output: Contribution to journalLetter

Metformin
Hepatocellular Carcinoma
Non-alcoholic Fatty Liver Disease

Letter: metformin reduces the risk of hepatocellular carcinoma in diabetic patients. Authors' reply

Vilar-Gomez, E. & Chalasani, N., Oct 1 2019, In : Alimentary pharmacology & therapeutics. 50, 7, p. 838-839 2 p.

Research output: Contribution to journalLetter

Metformin
Hepatocellular Carcinoma
5 Citations (Scopus)
Lipids
Liver
Wounds and Injuries
Fibrosis
Non-alcoholic Fatty Liver Disease
7 Citations (Scopus)
Metformin
Fatty Liver
Fibrosis
Hepatocellular Carcinoma
Transplants
8 Citations (Scopus)

Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review

Stahl, E. P., Dhindsa, D. S., Lee, S. K., Sandesara, P. B., Chalasani, N. & Sperling, L. S., Mar 5 2019, In : Journal of the American College of Cardiology. 73, 8, p. 948-963 16 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Cardiomyopathies
Lipid Metabolism
Insulin Resistance
Cardiac Arrhythmias

Novel HLA Class I Alleles Outside the Extended DR3 Haplotype Are Protective against Autoimmune Hepatitis

Lammert, C., McKinnon, E. J., Chalasani, N. & Phillips, E. J., Jun 1 2019, In : Clinical and translational gastroenterology. 10, 6, p. e00032

Research output: Contribution to journalArticle

Open Access
Autoimmune Hepatitis
Haplotypes
Alleles
HLA-A Antigens
HLA-B Antigens
1 Citation (Scopus)

Older Age and Disease Duration Are Highly Associated with Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis

Dakhoul, L., Jones, K. R., Gawrieh, S., Ghabril, M., McShane, C., Vuppalanchi, R., Vilar-Gomez, E., Nephew, L., Chalasani, N. & Lammert, C., Jan 1 2019, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Autoimmune Hepatitis
Hepatocellular Carcinoma
Fibrosis
Autoimmune Diseases
Medical Records
5 Citations (Scopus)

Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?

Tricò, D., Di Sessa, A., Caprio, S., Chalasani, N., Liu, W., Liang, T., Graf, J., Herzog, R. I., Johnson, C. D., Umano, G. R., Feldstein, A. E. & Santoro, N., Jan 10 2019, In : Antioxidants and Redox Signaling. 30, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

Pediatrics
Linoleic Acid
Metabolites
Derivatives
Fatty Acid Desaturases
4 Citations (Scopus)
Chemical and Drug Induced Liver Injury
Liver Diseases
Chronic Disease
Prescriptions
Non-alcoholic Fatty Liver Disease
5 Citations (Scopus)

Post hoc analyses of surrogate markers of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis in patients with type 2 diabetes in a digitally supported continuous care intervention: An open-label, non-randomised controlled study

Vilar-Gomez, E., Athinarayanan, S. J., Adams, R. N., Hallberg, S. J., Bhanpuri, N. H., McKenzie, A. L., Campbell, W. W., McCarter, J. P., Phinney, S. D., Volek, J. S. & Chalasani, N., Feb 1 2019, In : BMJ Open. 9, 2, 023597.

Research output: Contribution to journalArticle

Open Access
Liver Cirrhosis
Type 2 Diabetes Mellitus
Biomarkers
Fibrosis
Liver
3 Citations (Scopus)

Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension

Abraldes, J. G., Trebicka, J., Chalasani, N., D’Amico, G., Rockey, D. C., Shah, V. H., Bosch, J. & Garcia-Tsao, G., Mar 1 2019, In : Hepatology. 69, 3, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

Portal Hypertension
Portal Pressure
Fibrosis
Therapeutics
Industry
2 Citations (Scopus)

Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters

Zemel, M. B., Kolterman, O., Rinella, M., Vuppalanchi, R., Flores, O., Barritt, A. S., Siddiqui, M. & Chalasani, N., Jan 1 2019, In : Obesity. 27, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Metformin
Leucine
Randomized Controlled Trials
Sirtuin 1
Comorbidity
4 Citations (Scopus)

Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial

the NASH Clinical Research Network, May 1 2019, In : Alimentary Pharmacology and Therapeutics. 49, 9, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

Open Access
Fatty Liver
Lipoproteins
pioglitazone
E-Selectin
Vitamin E
8 Citations (Scopus)

Relationship between three commonly used non-invasive fibrosis biomarkers and improvement in fibrosis stage in patients with non-alcoholic steatohepatitis

Chalasani, N., Abdelmalek, M. F., Loomba, R., Kowdley, K. V., McCullough, A. J., Dasarathy, S., Neuschwander-Tetri, B. A., Terrault, N., Ferguson, B., Shringarpure, R., Shapiro, D. & Sanyal, A. J., May 1 2019, In : Liver International. 39, 5, p. 924-932 9 p.

Research output: Contribution to journalArticle

Fatty Liver
Fibrosis
Biomarkers
Transaminases
Blood Platelets

Reply

Vuppalanchi, R. & Chalasani, N., Jul 1 2019, In : Hepatology. 70, 1, p. 445-446 2 p.

Research output: Contribution to journalLetter

Reply

Vilar-Gomez, E. & Chalasani, N., Aug 1 2019, In : Hepatology (Baltimore, Md.). 70, 2, 1 p.

Research output: Contribution to journalLetter

6 Citations (Scopus)
Open Access
Cholestasis
Wounds and Injuries
Testosterone Congeners
Liver
Controlled Substances
1 Citation (Scopus)

Trends in Characteristics, Mortality, and Other Outcomes of Patients with Newly Diagnosed Cirrhosis

Orman, E., Roberts, A., Ghabril, M., Nephew, L., Desai, A., Patidar, K. & Chalasani, N., Jan 1 2019, In : JAMA Network Open.

Research output: Contribution to journalArticle

Open Access
Fibrosis
Mortality
Alcoholic Liver Cirrhosis
Hepatitis
Hepatocellular Carcinoma
28 Citations (Scopus)

Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease

NASH Clinical Research Network, Jan 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 1, p. 156-163.e2

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Fibrosis
Liver
ROC Curve