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  • Debomoy Lahiri
2020

Aging is not a disorder

Lahiri, D. K., Jan 1 2020, In : Current aging science. 13, 1, p. 2-3 2 p.

Research output: Contribution to journalEditorial

Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease (Translational Psychiatry, (2020), 10, 1, (47), 10.1038/s41398-020-0709-x)

Ray, B., Maloney, B., Sambamurti, K., Karnati, H. K., Nelson, P. T., Greig, N. H. & Lahiri, D. K., Dec 1 2020, In : Translational psychiatry. 10, 1, 81.

Research output: Contribution to journalComment/debate

Open Access

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Chopra, N., Wang, R., Maloney, B., Nho, K., Beck, J. S., Pourshafie, N., Niculescu, A., Saykin, A. J., Rinaldi, C., Counts, S. E. & Lahiri, D. K., Jan 1 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease

Ray, B., Maloney, B., Sambamurti, K., Karnati, H. K., Nelson, P. T., Greig, N. H. & Lahiri, D. K., Dec 1 2020, In : Translational psychiatry. 10, 1, 47.

Research output: Contribution to journalArticle

Open Access
2019

APPealing for a role in cellular iron efflux

Lahiri, D. K., Maloney, B. & Wang, R., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, 1 p.

Research output: Contribution to journalLetter

1 Scopus citations
2 Scopus citations

Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs

Niculescu, A. B., Le-Niculescu, H., Roseberry, K., Wang, S., Hart, J., Kaur, A., Robertson, H., Jones, T., Strasburger, A., Williams, A., Kurian, S. M., Lamb, B., Shekhar, A., Lahiri, D. K. & Saykin, A. J., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access

Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta)

Duffy, K. B., Ray, B., Lahiri, D. K., Tilmont, E. M., Tinkler, G. P., Herbert, R. L., Greig, N. H., Ingram, D. K., Ottinger, M. A. & Mattison, J. A., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations

Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD

Lahiri, D., Jan 1 2019, In : Current Alzheimer research. 16, 4, p. 279-280 2 p.

Research output: Contribution to journalEditorial

Open Access
Open Access

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

Konar, A., Gupta, R., Shukla, R. K., Maloney, B., Khanna, V. K., Wadhwa, R., Lahiri, D. K. & Thakur, M. K., Dec 1 2019, In : Scientific reports. 9, 1, 13990.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Moon missions spark the human imagination

Lahiri, D. K., Nov 1 2019, In : Science. 366, 6465, 1 p.

Research output: Contribution to journalLetter

Novel contribution of secreted amyloid-β precursor protein to white matter brain enlargement in autism spectrum disorder

Sokol, D. K., Maloney, B., Westmark, C. J. & Lahiri, D. K., Jan 1 2019, In : Frontiers in Psychiatry. 10, APR, 165.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

Long, J. M., Maloney, B., Rogers, J. T. & Lahiri, D. K., Mar 1 2019, In : Molecular Psychiatry. 24, 3, p. 345-363 19 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

(-)-phenserine and inhibiting pre-programmed cell death: In pursuit of a novel intervention for Alzheimer’s disease

Becker, R. E., Greig, N. H., Lahiri, D., Bledsoe, J., Majercik, S., Ballard, C., Aarsland, D., Schneider, L. S., Flanagan, D., Govindarajan, R., Sano, M., Ferrucci, L. & Kapogiannis, D., Jan 1 2018, In : Current Alzheimer Research. 15, 9, p. 883-891 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling

Konar, A., Kumar, A., Maloney, B., Lahiri, D. K. & Thakur, M. K., Dec 1 2018, In : Scientific reports. 8, 1, 9928.

Research output: Contribution to journalArticle

3 Scopus citations

Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis

Maloney, B., Bayon, B. L., Zawia, N. H. & Lahiri, D. K., Sep 2018, In : NeuroToxicology. 68, p. 126-132 7 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin

Venkataramani, V., Doeppner, T. R., Willkommen, D., Cahill, C. M., Xin, Y., Ye, G., Liu, Y., Southon, A., Aron, A., Au-Yeung, H. Y., Huang, X., Lahiri, D. K., Wang, F., Bush, A. I., Wulf, G. G., Ströbel, P., Michalke, B. & Rogers, J. T., Dec 2018, In : Journal of Neurochemistry. 147, 6, p. 831-848 18 p.

Research output: Contribution to journalArticle

17 Scopus citations
2 Scopus citations

Understanding healthy protective mechanisms against old age

Lahiri, D., Jan 1 2018, In : Current Aging Science. 11, 1, p. 2-3 2 p.

Research output: Contribution to journalEditorial

2017

A cardinal sin when researching neuropsin/KLK8: Thou shalt validate antibodies

Lahiri, D., Konar, A., Thakur, M. K. & Maloney, B., 2017, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

Shah, K. & Lahiri, D. K., Apr 1 2017, In : Molecular Neurobiology. 54, 3, p. 2255-2268 14 p.

Research output: Contribution to journalReview article

22 Scopus citations

Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease

Srinivasan, M. & Lahiri, D. K., Dec 1 2017, In : Molecular Neurobiology. 54, 10, p. 8063-8070 8 p.

Research output: Contribution to journalReview article

9 Scopus citations

Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism

Erickson, C. A., Ray, B., Wink, L. K., Bayon, B. L., Pedapati, E. V., Shaffer, R., Schaefer, T. L. & Lahiri, D. K., Jan 1 2017, In : Journal of Psychiatric Research. 84, p. 153-160 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Potential for stem cells therapy in alzheimer’s disease: Do neurotrophic factors play critical role?

Bali, P., Lahiri, D., Banik, A., Nehru, B. & Anand, A., Feb 1 2017, In : Current Alzheimer Research. 14, 2, p. 208-220 13 p.

Research output: Contribution to journalReview article

16 Scopus citations

Targeting tumor necrosis factor alpha for Alzheimer’s disease

Decourt, B., Lahiri, D. & Sabbagh, M. N., Apr 1 2017, In : Current Alzheimer Research. 14, 4, p. 412-425 14 p.

Research output: Contribution to journalReview article

45 Scopus citations

When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author

Lahiri, D. K., Maloney, B. & Sambamurti, K., Nov 30 2017, In : Gene. 635, p. 46-47 2 p.

Research output: Contribution to journalLetter

2016

Analysis of peripheral amyloid precursor protein in Angelman Syndrome

Erickson, C. A., Wink, L. K., Baindu, B., Ray, B., Schaefer, T. L., Pedapati, E. V. & Lahiri, D., Sep 1 2016, In : American Journal of Medical Genetics, Part A. 170, 9, p. 2334-2337 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Epigenetics of dementia: understanding the disease as a transformation rather than a state

Maloney, B. & Lahiri, D., Jun 1 2016, In : The Lancet. Neurology. 15, 7, p. 760-774 15 p.

Research output: Contribution to journalReview article

52 Scopus citations
15 Scopus citations

Novel nuclear factor-KappaB targeting peptide suppresses β-amyloid induced inflammatory and apoptotic responses in neuronal cells

Srinivasan, M., Bayon, B., Chopra, N. & Lahiri, D., Oct 1 2016, In : PLoS One. 11, 10, e0160314.

Research output: Contribution to journalArticle

5 Scopus citations

Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism

Westmark, C. J., Sokol, D. K., Maloney, B. & Lahiri, D. K., Oct 1 2016, In : Molecular Psychiatry. 21, 10, p. 1333-1341 9 p.

Research output: Contribution to journalReview article

20 Scopus citations

Potential for stem cells therapy in Alzheimer’s disease: Do neurotrophic factors play critical role?

Bali, P., Lahiri, D., Banik, A., Nehru, B. & Anand, A., Sep 1 2016, In : Current Alzheimer Research. 13, 9

Research output: Contribution to journalArticle

3 Scopus citations

Transgenerational latent early-life associated regulation unites environment and genetics across generations

Lahiri, D., Maloney, B., Bayon, B. L., Chopra, N., White, F., Greig, N. H. & Nurnberger, J., Mar 1 2016, In : Epigenomics. 8, 3, p. 373-387 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Translational Alzheimer’s disease research

Huang, Y. & Lahiri, D., Mar 1 2016, In : Current Alzheimer Research. 13, 3, p. 214 1 p.

Research output: Contribution to journalArticle

2015

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer’s disease

Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Oct 1 2015, In : Current Alzheimer research. 12, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

115 Scopus citations

Daidzein augments cholesterol homeostasis via apoE to promote functional recovery in chronic stroke

Kim, E., Woo, M. S., Qin, L., Ma, T., Beltran, C. D., Bao, Y., Bailey, J. A., Corbett, D., Ratan, R. R., Lahiri, D. & Cho, S., Nov 11 2015, In : Journal of Neuroscience. 35, 45, p. 15113-15126 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Oral administration of thioflavin t prevents beta amyloid plaque formation in double transgenic ad mice

Sarkar, S., Raymick, J., Ray, B., Lahiri, D., Paule, M. G. & Schmued, L., Nov 1 2015, In : Current Alzheimer Research. 12, 9, p. 837-846 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
61 Scopus citations

The neurobehavioral and molecular phenotype of Angelman Syndrome

Wink, L. K., Fitzpatrick, S., Shaffer, R., Melnyk, S., Begtrup, A. H., Fox, E., Schaefer, T. L., Mathieu-Frasier, L., Ray, B., Lahiri, D., Horn, P. A. & Erickson, C. A., Nov 1 2015, In : American Journal of Medical Genetics, Part A. 167, 11, p. 2623-2628 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Translation of pre-clinical studies into successful clinical trials for Alzheimer's disease: What are the roadblocks and how can they be overcome?

Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., Mukaetova-Ladinska, E., Ihara, M., Srivastava, S., Srivastava, M. V. P., Masters, C. L., Kalaria, R. N. & Anand, A., Aug 11 2015, In : Journal of Alzheimer's Disease. 47, 4, p. 815-843 29 p.

Research output: Contribution to journalReview article

21 Scopus citations

View of excellent road from the car

Lahiri, D. K., May 1 2015, In : Current Alzheimer research. 12, 2, p. 96-99 4 p.

Research output: Contribution to journalEditorial

1 Scopus citations

What can triumphs and tribulations from drug research in Alzheimer's disease tell us about the development of psychotropic drugs in general?

Becker, R. E., Seeman, M. V., Greig, N. H. & Lahiri, D. K., Aug 1 2015, In : The Lancet Psychiatry. 2, 8, p. 756-764 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

What is aging for? That remains the question

Lahiri, D. K., Jun 1 2015, In : Current aging science. 8, 1, 1 p.

Research output: Contribution to journalEditorial

3 Scopus citations
2014

Advances in understanding Alzheimer's disease, and the contributions of Current Alzheimer Research: Ten years on and beyond

Greig, N. H. & Lahiri, D. K., Jan 1 2014, In : Current Alzheimer research. 11, 2, p. 107-109 3 p.

Research output: Contribution to journalEditorial

4 Scopus citations

Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment

Greig, N. H., Sambamurti, K., Lahiri, D. K. & Becker, R. E., Oct 1 2014, In : Annals of Neurology. 76, 4, p. 629-630 2 p.

Research output: Contribution to journalLetter

3 Scopus citations

Cdk5 activity in the brain - multiple paths of regulation

Shah, K. & Lahiri, D., Jun 1 2014, In : Journal of Cell Science. 127, p. 2391-2400 10 p.

Research output: Contribution to journalReview article

51 Scopus citations

Cdk5 activity in the brain - multiple paths of regulation

Shah, K. & Lahiri, D. K., Jun 2014, In : Journal of cell science. 127, 11, p. 2407-2419 13 p.

Research output: Contribution to journalArticle

25 Scopus citations