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  • Zhong-Yin Zhang
2020

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K. H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., Jan 15 2020, In : EMBO Journal. 39, 2, e103637.

Research output: Contribution to journalArticle

Open Access
2019

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z. Y., Gribble, G. W., Spinola, S. M. & Duerfeldt, A. S., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1836-1841 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Small molecules target the interaction between tissue transglutaminase and fibronectin

Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N. G., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z. Y. & Matei, D., Jan 1 2019, In : Molecular cancer therapeutics. 18, 6, p. 1057-1068 12 p.

Research output: Contribution to journalArticle

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z. Y., Tsao, M. S., Ikura, M. & Ohh, M., Dec 1 2019, In : Nature communications. 10, 1, 224.

Research output: Contribution to journalArticle

7 Scopus citations
2018

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z. Y. & Deng, Q., Mar 29 2018, In : Frontiers in immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

6 Scopus citations

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z. Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., Sep 2018, In : eLife. 7, e38704.

Research output: Contribution to journalArticle

13 Scopus citations

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Xu, J., Lee, S. S. Y., Seo, H., Pang, L., Jun, Y., Zhang, R. Y., Zhang, Z. Y., Kim, P., Lee, W., Kron, S. J. & Yeo, Y., Dec 13 2018, In : Small. 14, 50, 1803601.

Research output: Contribution to journalArticle

7 Scopus citations

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Yu, Z. H. & Zhang, Z-Y., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1069-1091 23 p.

Research output: Contribution to journalReview article

24 Scopus citations

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

McQueeney, K. E., Salamoun, J. M., Burnett, J. C., Barabutis, N., Pekic, P., Lewandowski, S. L., Llaneza, D. C., Cornelison, R., Bai, Y., Zhang, Z. Y., Catravas, J. D., Landen, C. N., Wipf, P., Lazo, J. S. & Sharlow, E. R., Jan 1 2018, In : Oncotarget. 9, 9, p. 8223-8240 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Zehender, A., Huang, J., Györfi, A. H., Matei, A. E., Trinh-Minh, T., Xu, X., Li, Y. N., Chen, C. W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z. Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. & Distler, J. H. W., Dec 1 2018, In : Nature communications. 9, 1, 3259.

Research output: Contribution to journalArticle

14 Scopus citations

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A. & Dai, M., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17465-17473 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Covalent inhibition of protein tyrosine phosphatases

Ruddraraju, K. V. & Zhang, Z. Y., Jan 1 2017, In : Molecular BioSystems. 13, 7, p. 1257-1279 23 p.

Research output: Contribution to journalReview article

11 Scopus citations

Drugging the undruggable: Therapeutic potential of targeting protein tyrosine phosphatases

Zhang, Z. Y., Jan 1 2017, In : Accounts of Chemical Research. 50, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H., Yoder, M., Kapur, R., Mulloy, J. C., Zhang, Z-Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia

Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z. Y. & Liu, Y., Mar 1 2017, In : Leukemia. 31, 3, p. 751-754 4 p.

Research output: Contribution to journalLetter

5 Scopus citations

Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

Yamashita, N., Joshi, R., Zhang, S., Zhang, Z. Y. & Kuruvilla, R., Sep 25 2017, In : Developmental Cell. 42, 6, p. 626-639.e5

Research output: Contribution to journalArticle

16 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Sacchetti, C., Bai, Y., Stanford, S. M., Di Benedetto, P., Cipriani, P., Santelli, E., Piera-Velazquez, S., Chernitskiy, V., Kiosses, W. B., Ceponis, A., Kaestner, K. H., Boin, F., Jimenez, S. A., Giacomelli, R., Zhang, Z. Y. & Bottini, N., Dec 1 2017, In : Nature communications. 8, 1, 1060.

Research output: Contribution to journalArticle

16 Scopus citations

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., Wang, Q., Shen, H., Yao, X., Zhang, Z. Y., Xue, S., Shen, L. & Cheng, J., Jan 1 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Therapeutic targeting of oncogenic tyrosine phosphatases

Frankson, R., Yu, Z. H., Bai, Y., Li, Q., Zhang, R. Y. & Zhang, Z. Y., Nov 1 2017, In : Cancer Research. 77, 21, p. 5701-5705 5 p.

Research output: Contribution to journalReview article

32 Scopus citations

The tumor promoter-activated protein kinase Cs are a system for regulating filopodia

Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z-Y. & Boudreau, N. S., Aug 1 2017, In : Cytoskeleton. 74, 8, p. 297-314 18 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Song, G. J., Jung, M., Kim, J. H., Park, H., Rahman, M. H., Zhang, S., Zhang, Z-Y., Park, D. H., Kook, H., Lee, I. K. & Suk, K., 2016, In : Journal of Neuroinflammation. 13, 1, 86.

Research output: Contribution to journalArticle

39 Scopus citations

Comparative analysis of protein tyrosine phosphatases regulating microglial activation

Song, G. J., Kim, J., Kim, J. H., Song, S., Park, H., Zhang, Z. Y. & Suk, K., Oct 1 2016, In : Experimental Neurobiology. 25, 5, p. 252-261 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Current status of PTP-based therapeutics

He, R. & Zhang, Z-Y., Jan 1 2016, Protein Tyrosine Phosphatases in Cancer. Springer New York, p. 335-353 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Li, Y., Xia, G., Guo, Q., Wu, L., Chen, S., Yang, Z., Wang, W., Zhang, Z. Y., Zhou, X. & Jiang, Z. X., Jan 1 2016, In : MedChemComm. 7, 8, p. 1672-1680 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery and evaluation of PRL trimer disruptors for novel anticancer agents

Bai, Y., Yu, Z. H. & Zhang, Z. Y., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1447. p. 121-138 18 p. (Methods in Molecular Biology; vol. 1447).

Research output: Chapter in Book/Report/Conference proceedingChapter

EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells

Bai, S., Ingram, P., Chen, Y. C., Deng, N., Pearson, A., Niknafs, Y., O'Hayer, P., Wang, Y., Zhang, Z. Y., Boscolo, E., Bischoff, J., Yoon, E. & Buckanovich, R. J., Nov 1 2016, In : Cancer Research. 76, 21, p. 6396-6409 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

He, R., Wang, J., Yu, Z. H., Zhang, R. Y., Liu, S., Wu, L. & Zhang, Z. Y., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9094-9106 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus

Wang, J., Mizui, M., Zeng, L. F., Bronson, R., Finnell, M., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z. Y. & Kontaridis, M. I., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2077-2092 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen

Dutta, N. K., He, R., Pinn, M. L., He, Y., Burrows, F., Zhang, Z-Y. & Karakousis, P. C., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

Hamerman, J. A., Pottle, J., Ni, M., He, Y., Zhang, Z. Y. & Buckner, J. H., Jan 1 2016, In : Immunological Reviews. 269, 1, p. 212-227 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

Bai, Y., Yu, Z. H., Liu, S., Zhang, L., Zhang, R. Y., Zeng, L. F., Zhang, S. & Zhang, Z. Y., Aug 15 2016, In : Cancer Research. 76, 16, p. 4805-4815 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis

Bai, Y., Zhou, H. M., Zhang, L., Dong, Y., Zeng, Q., Shou, W. & Zhang, Z. Y., Sep 26 2016, In : Scientific reports. 6, 34211.

Research output: Contribution to journalArticle

8 Scopus citations

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Zhang, R. Y., Yu, Z. H., Zeng, L., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. & Zhang, Z. Y., Jan 1 2016, In : Oncotarget. 7, 45, p. 73817-73829 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, p. 783-792 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Oct 1 2016, In : Leukemia. 30, 10, p. 2094-2097 4 p.

Research output: Contribution to journalLetter

8 Scopus citations
2015

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase

He, Y., Guo, X., Yu, Z. H., Wu, L., Gunawan, A. M., Zhang, Y., Dixon, J. E. & Zhang, Z. Y., May 29 2015, In : Bioorganic and Medicinal Chemistry. 23, 12, p. 2798-2809 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis

He, R., Yu, Z. H., Zhang, R. Y., Wu, L., Gunawan, A. M. & Zhang, Z-Y., Dec 10 2015, In : ACS Medicinal Chemistry Letters. 6, 12, p. 1231-1235 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system

Van Rensburg, J. J., Fortney, K. R., Chen, L., Krieger, A. J., Lima, B. P., Wolfe, A. J., Katz, B. P., Zhang, Z. Y. & Spinola, S. M., Jul 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 3789-3799 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

He, R., Yu, Z. H., Zhang, R. Y., Wu, L., Gunawan, A. M., Lane, B. S., Shim, J. S., Zeng, L. F., He, Y., Chen, L., Wells, C. D., Liu, J. O. & Zhang, Z. Y., Jul 9 2015, In : ACS Medicinal Chemistry Letters. 6, 7, p. 782-786 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Bunda, S., Burrell, K., Heir, P., Zeng, L., Alamsahebpour, A., Kano, Y., Raught, B., Zhang, Z. Y., Zadeh, G. & Ohh, M., Nov 30 2015, In : Nature communications. 6, 8859.

Research output: Contribution to journalArticle

60 Scopus citations

Leptin and insulin act on POMC neurons to promote the browning of white fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z. Y., Kahn, B. B., Neel, B. G., Bence, K. K., Andrews, Z. B., Cowley, M. A. & Tiganis, T., Jan 15 2015, In : Cell. 160, 1-2, p. 88-104 17 p.

Research output: Contribution to journalArticle

164 Scopus citations

Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice

Xi, Y., Liu, S., Bettaieb, A., Matsuo, K., Matsuo, I., Hosein, E., Chahed, S., Wiede, F., Zhang, S., Zhang, Z. Y., Kulkarni, R. N., Tiganis, T. & Haj, F. G., Jan 1 2015, In : Diabetologia. 58, 1, p. 122-131 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Zhang, Z. Y., Dodd, G. T. & Tiganis, T., Oct 1 2015, In : Trends in Pharmacological Sciences. 36, 10, p. 661-674 14 p.

Research output: Contribution to journalReview article

78 Scopus citations

Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals

Zhu, H. H., Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z., Zhou, Z., Yao, J., Zeng, L., Ji, K., Gao, W. Q., Zhang, Z. Y. & Feng, G. S., Oct 27 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 43, p. 13342-13347 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis

Paudyal, M. P., Wu, L., Zhang, Z. Y., Spilling, C. D. & Wong, C. F., Dec 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 24, p. 6781-6788 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases

Selner, N. G., Luechapanichkul, R., Chen, X., Neel, B. G., Zhang, Z. Y., Knapp, S., Bell, C. E. & Pei, D., Jan 21 2014, In : Biochemistry. 53, 2, p. 397-412 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis

He, R., Bai, Y., Yu, Z. H., Wu, L., Gunawan, A. M. & Zhang, Z. Y., Oct 1 2014, In : MedChemComm. 5, 10, p. 1496-1499 4 p.

Research output: Contribution to journalArticle

5 Scopus citations