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2020

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K. H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., Jan 15 2020, In : EMBO Journal. 39, 2, e103637.

Research output: Contribution to journalArticle

Open Access
T-cells
T-Cell Antigen Receptor
Phosphoric Monoester Hydrolases
Tumors
Immunity
2019

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z-Y., Gribble, G. W., Spinola, S. & Duerfeldt, A. S., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Phosphoric Monoester Hydrolases
Amines
Indoles
Scaffolds

Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin

Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N. G., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z. Y. & Matei, D., Jun 1 2019, In : Molecular cancer therapeutics. 18, 6, p. 1057-1068 12 p.

Research output: Contribution to journalArticle

Fibronectins
Ovarian Neoplasms
Cell-Matrix Junctions
Interferometry
Focal Adhesion Protein-Tyrosine Kinases
6 Citations (Scopus)

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z-Y., Tsao, M. S., Ikura, M. & Ohh, M., Dec 1 2019, In : Nature Communications. 10, 1, 224.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
GTP Phosphohydrolases
Conformations
switches
2018
5 Citations (Scopus)

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z-Y. & Deng, Q., Mar 29 2018, In : Frontiers in Immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

Endotoxemia
Zebrafish
Inflammation
Myeloid Differentiation Factor 88
Protein Tyrosine Phosphatases
10 Citations (Scopus)

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z-Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., Sep 19 2018, In : eLife. 7

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Neuronal Plasticity
Metabolism
Plasticity
Neurons
4 Citations (Scopus)

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Xu, J., Lee, S. S. Y., Seo, H., Pang, L., Jun, Y., Zhang, R. Y., Zhang, Z-Y., Kim, P., Lee, W., Kron, S. J. & Yeo, Y., Jan 1 2018, (Accepted/In press) In : Small. 1803601.

Research output: Contribution to journalArticle

Quinic Acid
Selectins
Drug delivery
Nanoparticles
Tumors
17 Citations (Scopus)

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Yu, Z. H. & Zhang, Z-Y., Feb 14 2018, In : Chemical Reviews. 118, 3, p. 1069-1091 23 p.

Research output: Contribution to journalReview article

Protein Tyrosine Phosphatases
Phosphorylation
Cell signaling
Tyrosine
Oligomerization
8 Citations (Scopus)

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

McQueeney, K. E., Salamoun, J. M., Burnett, J. C., Barabutis, N., Pekic, P., Lewandowski, S. L., Llaneza, D. C., Cornelison, R., Bai, Y., Zhang, Z-Y., Catravas, J. D., Landen, C. N., Wipf, P., Lazo, J. S. & Sharlow, E. R., Jan 1 2018, In : Oncotarget. 9, 9, p. 8223-8240 18 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Ovarian Neoplasms
Endothelium
Neoplasms
Pericytes
10 Citations (Scopus)

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Zehender, A., Huang, J., Györfi, A. H., Matei, A. E., Trinh-Minh, T., Xu, X., Li, Y. N., Chen, C. W., Lin, J., Dees, C., Beyer, C., Gelse, K., Zhang, Z-Y., Bergmann, C., Ramming, A., Birchmeier, W., Distler, O., Schett, G. & Distler, J. H. W., Dec 1 2018, In : Nature Communications. 9, 1, 3259.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
fibrosis
phosphatases
tyrosine
fibroblasts
3 Citations (Scopus)

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z-Y., Adibekian, A. & Dai, M., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17465-17473 9 p.

Research output: Contribution to journalArticle

Abies
Phosphatases
Molecules
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Proteins
2017
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
10 Citations (Scopus)

Covalent inhibition of protein tyrosine phosphatases

Ruddraraju, K. V. & Zhang, Z-Y., 2017, In : Molecular BioSystems. 13, 7, p. 1257-1279 23 p.

Research output: Contribution to journalReview article

Protein Tyrosine Phosphatases
Tyrosine
Isothiocyanates
Epoxy Compounds
Ketones
37 Citations (Scopus)

Drugging the undruggable: Therapeutic potential of targeting protein tyrosine phosphatases

Zhang, Z-Y., Jan 1 2017, In : Accounts of Chemical Research. 50, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Phosphorylation
Tyrosine
Medical problems
Oncology
4 Citations (Scopus)

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H., Yoder, M., Kapur, R., Mulloy, J. C., Zhang, Z-Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
5 Citations (Scopus)

Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia

Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z-Y. & Liu, Y., Mar 1 2017, In : Leukemia. 31, 3, p. 751-754 4 p.

Research output: Contribution to journalLetter

T-Cell Leukemia
Phosphoric Monoester Hydrolases
15 Citations (Scopus)

Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

Yamashita, N., Joshi, R., Zhang, S., Zhang, Z-Y. & Kuruvilla, R., Sep 25 2017, In : Developmental Cell. 42, 6, p. 626-639.e5

Research output: Contribution to journalArticle

Nerve Growth Factor Receptors
Transcytosis
trkA Receptor
Carisoprodol
Axons
6 Citations (Scopus)

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M., Kapur, R., Kaplan, M., Daniel Lacorazza, H., Zhang, Z-Y. & Liu, Y., Apr 1 2017, In : Stem Cells. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Hematopoietic Stem Cells
T-Lymphocytes
Cell Differentiation
Stem Cell Factor
14 Citations (Scopus)

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Sacchetti, C., Bai, Y., Stanford, S. M., Di Benedetto, P., Cipriani, P., Santelli, E., Piera-Velazquez, S., Chernitskiy, V., Kiosses, W. B., Ceponis, A., Kaestner, K. H., Boin, F., Jimenez, S. A., Giacomelli, R., Zhang, Z-Y. & Bottini, N., Dec 1 2017, In : Nature Communications. 8, 1, 1060.

Research output: Contribution to journalArticle

fibrosis
phosphatases
Systemic Scleroderma
Fibroblasts
Phosphoric Monoester Hydrolases
7 Citations (Scopus)

SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., Wang, Q., Shen, H., Yao, X., Zhang, Z-Y., Xue, S., Shen, L. & Cheng, J., Apr 1 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

Interferons
Macrophages
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Sumoylation
Listeriosis
24 Citations (Scopus)

Therapeutic targeting of oncogenic tyrosine phosphatases

Frankson, R., Yu, Z. H., Bai, Y., Li, Q., Zhang, R. Y. & Zhang, Z-Y., Nov 1 2017, In : Cancer Research. 77, 21, p. 5701-5705 5 p.

Research output: Contribution to journalReview article

Phosphoric Monoester Hydrolases
Tyrosine
Protein Tyrosine Phosphatases
Neoplasms
Drug Discovery
1 Citation (Scopus)

The tumor promoter-activated protein kinase Cs are a system for regulating filopodia

Heckman, C. A., Pandey, P., Cayer, M. L., Biswas, T., Zhang, Z-Y. & Boudreau, N. S., Aug 1 2017, In : Cytoskeleton. 74, 8, p. 297-314 18 p.

Research output: Contribution to journalArticle

Pseudopodia
Carcinogens
Protein Kinases
Protein Kinase C
Protein Isoforms
2016
34 Citations (Scopus)

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Song, G. J., Jung, M., Kim, J. H., Park, H., Rahman, M. H., Zhang, S., Zhang, Z-Y., Park, D. H., Kook, H., Lee, I. K. & Suk, K., 2016, In : Journal of Neuroinflammation. 13, 1, 86.

Research output: Contribution to journalArticle

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Nitric Oxide
Brain
Microglia
Encephalitis
4 Citations (Scopus)

Comparative analysis of protein tyrosine phosphatases regulating microglial activation

Song, G. J., Kim, J., Kim, J. H., Song, S., Park, H., Zhang, Z-Y. & Suk, K., Oct 1 2016, In : Experimental Neurobiology. 25, 5, p. 252-261 10 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Lipopolysaccharides
Neuroglia
Brain
Microglia

Current status of PTP-based therapeutics

He, R. & Zhang, Z-Y., Jan 1 2016, Protein Tyrosine Phosphatases in Cancer. Springer New York, p. 335-353 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein Tyrosine Phosphatases
Phosphorylation
Tyrosine
Tumors
Neoplasms
5 Citations (Scopus)

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Li, Y., Xia, G., Guo, Q., Wu, L., Chen, S., Yang, Z., Wang, W., Zhang, Z-Y., Zhou, X. & Jiang, Z. X., 2016, In : MedChemComm. 7, 8, p. 1672-1680 9 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Magnetic resonance
Magnetic Resonance Spectroscopy
Fluorine
Imaging techniques

Discovery and evaluation of PRL trimer disruptors for novel anticancer agents

Bai, Y., Yu, Z. H. & Zhang, Z. Y., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1447. p. 121-138 18 p. (Methods in Molecular Biology; vol. 1447).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphoric Monoester Hydrolases
Antineoplastic Agents
Neoplasms
Therapeutics
21 Citations (Scopus)

EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells

Bai, S., Ingram, P., Chen, Y. C., Deng, N., Pearson, A., Niknafs, Y., O'Hayer, P., Wang, Y., Zhang, Z-Y., Boscolo, E., Bischoff, J., Yoon, E. & Buckanovich, R. J., Nov 1 2016, In : Cancer Research. 76, 21, p. 6396-6409 14 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Maintenance
Neoplastic Stem Cells
Neoplasm Metastasis
Neoplasms

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J-T., Feb 11 2016, In : Oncogene. 35, 6, p. 802 1 p.

Research output: Contribution to journalArticle

Oncogenes
Neoplasm Metastasis
Gene Expression
DNA
Growth
5 Citations (Scopus)

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

He, R., Wang, J., Yu, Z. H., Zhang, R. Y., Liu, S., Wu, L. & Zhang, Z-Y., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9094-9106 13 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Molecular Weight
Amides
Acetic Acid
X Ray Crystallography
18 Citations (Scopus)

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus

Wang, J., Mizui, M., Zeng, L. F., Bronson, R., Finnell, M., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z-Y. & Kontaridis, M. I., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2077-2092 16 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Inbred MRL lpr Mouse
Interleukin-17
Autoimmunity
SH2 Domain-Containing Protein Tyrosine Phosphatases
12 Citations (Scopus)

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen

Dutta, N. K., He, R., Pinn, M. L., He, Y., Burrows, F., Zhang, Z-Y. & Karakousis, P. C., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium tuberculosis
Tuberculosis
Virulence Factors
Pharmaceutical Preparations
43 Citations (Scopus)

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

Hamerman, J. A., Pottle, J., Ni, M., He, Y., Zhang, Z-Y. & Buckner, J. H., Jan 1 2016, In : Immunological Reviews. 269, 1, p. 212-227 16 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Myeloid Cells
Autoimmune Diseases
Cytokines
Autoimmunity
21 Citations (Scopus)

Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

Bai, Y., Yu, Z. H., Liu, S., Zhang, L., Zhang, R. Y., Zeng, L. F., Zhang, S. & Zhang, Z-Y., Aug 15 2016, In : Cancer Research. 76, 16, p. 4805-4815 11 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Antineoplastic Agents
Liver
Pharmaceutical Chemistry
Oncogene Proteins
6 Citations (Scopus)

Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis

Bai, Y., Zhou, H. M., Zhang, L., Dong, Y., Zeng, Q., Shou, W. & Zhang, Z-Y., Sep 26 2016, In : Scientific Reports. 6, 34211.

Research output: Contribution to journalArticle

Spermatogenesis
Phosphoric Monoester Hydrolases
Liver
Testis
PTEN Phosphohydrolase
18 Citations (Scopus)

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Zhang, R. Y., Yu, Z. H., Zeng, L., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. & Zhang, Z-Y., 2016, In : Oncotarget. 7, 45, p. 73817-73829 13 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Melanoma
Therapeutics
Cell Movement
Neoplasms
8 Citations (Scopus)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Jun 3 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
Syk Kinase
2015
8 Citations (Scopus)

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase

He, Y., Guo, X., Yu, Z. H., Wu, L., Gunawan, A. M., Zhang, Y., Dixon, J. E. & Zhang, Z-Y., Jan 22 2015, In : Bioorganic and Medicinal Chemistry. 23, 12, p. 2798-2809 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Phosphoric Monoester Hydrolases
Libraries
Salicylic Acid
8 Citations (Scopus)

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis

He, R., Yu, Z. H., Zhang, R. Y., Wu, L., Gunawan, A. M. & Zhang, Z-Y., Dec 10 2015, In : ACS Medicinal Chemistry Letters. 6, 12, p. 1231-1235 5 p.

Research output: Contribution to journalArticle

Cefsulodin
Drug Discovery
Mycobacterium tuberculosis
Phosphoric Monoester Hydrolases
Amides
13 Citations (Scopus)

Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system

Van Rensburg, J. J., Fortney, K. R., Chen, L., Krieger, A. J., Lima, B. P., Wolfe, A. J., Katz, B., Zhang, Z-Y. & Spinola, S., Jul 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 3789-3799 11 p.

Research output: Contribution to journalArticle

Signal Transduction
Haemophilus ducreyi
Salmonella enterica
Gene Deletion
Virulence Factors
16 Citations (Scopus)

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

He, R., Yu, Z. H., Zhang, R. Y., Wu, L., Gunawan, A. M., Lane, B. S., Shim, J. S., Zeng, L. F., He, Y., Chen, L., Wells, C., Liu, J. O. & Zhang, Z-Y., Jul 9 2015, In : ACS Medicinal Chemistry Letters. 6, 7, p. 782-786 5 p.

Research output: Contribution to journalArticle

Phosphotyrosine
Protein Tyrosine Phosphatases
Cefsulodin
Amides
Acetic Acid
58 Citations (Scopus)

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Bunda, S., Burrell, K., Heir, P., Zeng, L., Alamsahebpour, A., Kano, Y., Raught, B., Zhang, Z-Y., Zadeh, G. & Ohh, M., Nov 30 2015, In : Nature Communications. 6, 8859.

Research output: Contribution to journalArticle

Glioblastoma
mice
Tyrosine
Carcinogenesis
tyrosine
150 Citations (Scopus)

Leptin and insulin act on POMC neurons to promote the browning of white fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z-Y., Kahn, B. B., Neel, B. G., Bence, K. K., Andrews, Z. B., Cowley, M. A. & Tiganis, T., Jan 15 2015, In : Cell. 160, 1-2, p. 88-104 17 p.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
White Adipose Tissue
Leptin
Neurons
Fats
72 Citations (Scopus)

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Zhang, Z-Y., Dodd, G. T. & Tiganis, T., Oct 1 2015, In : Trends in Pharmacological Sciences. 36, 10, p. 661-674 14 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Non-Receptor Type 2 Protein Tyrosine Phosphatase
Leptin
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Insulin
8 Citations (Scopus)

Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals

Zhu, H. H., Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z., Zhou, Z., Yao, J., Zeng, L., Ji, K., Gao, W. Q., Zhang, Z-Y. & Feng, G. S., Oct 27 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 43, p. 13342-13347 6 p.

Research output: Contribution to journalArticle

Erythropoiesis
Phosphoric Monoester Hydrolases
Mammals
Anemia
Myelopoiesis
47 Citations (Scopus)

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H., Zhang, Z-Y., Liu, J. Y. & Zhang, J-T., Jun 15 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Neoplasm Metastasis
Gene Expression
DNA
Growth
2014
2 Citations (Scopus)

A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis

Paudyal, M. P., Wu, L., Zhang, Z-Y., Spilling, C. D. & Wong, C. F., Dec 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 24, p. 6781-6788 8 p.

Research output: Contribution to journalArticle

Yersinia pestis
Salicylic Acid
Screening
Derivatives
Protein Tyrosine Phosphatases
14 Citations (Scopus)

Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases

Selner, N. G., Luechapanichkul, R., Chen, X., Neel, B. G., Zhang, Z-Y., Knapp, S., Bell, C. E. & Pei, D., Jan 21 2014, In : Biochemistry. 53, 2, p. 397-412 16 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Substrates
Static Electricity
Catalytic Domain
Peptides
5 Citations (Scopus)

Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis

He, R., Bai, Y., Yu, Z. H., Wu, L., Gunawan, A. M. & Zhang, Z-Y., Oct 1 2014, In : MedChemComm. 5, 10, p. 1496-1499 4 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium
Mycobacterium tuberculosis
Phosphoric Monoester Hydrolases
Tuberculosis
4 Citations (Scopus)

Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta

Zeng, L. F., Zhang, R. Y., Bai, Y., Wu, L., Gunawan, A. M. & Zhang, Z-Y., May 10 2014, In : Antioxidants and Redox Signaling. 20, 14, p. 2130-2140 11 p.

Research output: Contribution to journalArticle

Class 5 Receptor-Like Protein Tyrosine Phosphatases
Protein Tyrosine Phosphatases
Carboxylic Acids
Proteins
Catalytic Domain